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Incidence of seizures in patients with multiple sclerosis: a population-based study.

Abstract

OBJECTIVE

To determine whether multiple sclerosis (MS) is associated with occurrence of seizure activity.

PATIENTS AND METHODS

The medical records of all incidence patients with MS in Olmsted County, Minnesota, from 1935 to 1991 were reviewed. The incidence of seizures was calculated by using 3 methods: including only seizures that occurred after definite diagnosis of MS, including all seizures occurring after onset of the first symptoms of MS, and including any seizures regardless of the time of onset relative to MS. These incidences were age-adjusted to the 1970 US population and then compared with the age-adjusted incidence rate of seizures in the general population of Olmsted County.

RESULTS

The age-adjusted incidence of seizures among MS patients was not significantly higher than the age-adjusted incidence of seizures in the general population of Olmsted County. The age-adjusted incidence of first unprovoked seizures in Rochester, Minn, was 61 per 100,000 person-years. In patients with the definite diagnosis of MS, the age-adjusted Incidence was calculated at 61 per 100,000 person-years (95% confidence interval [CI], 7-114). In the group with seizures after onset of symptoms, the age-adjusted incidence rate was 80 per 100,000 person-years (95% CI, 24-135). In the group with seizures at any time in their life, the age-adjusted incidence rate was 82 per 100,000 person-years (95% CI, 41-158).

CONCLUSION

The present study does not suggest that occurrence of seizures is more common in MS patients than in the general population.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA.

    , , ,

    Source

    Mayo Clinic proceedings 77:9 2002 Sep pg 910-2

    MeSH

    Adult
    Age of Onset
    Aged
    Cohort Studies
    Databases, Factual
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Minnesota
    Multiple Sclerosis
    Risk Factors
    Seizures
    Survival Analysis
    Survival Rate
    United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12233923

    Citation

    Nyquist, Paul A., et al. "Incidence of Seizures in Patients With Multiple Sclerosis: a Population-based Study." Mayo Clinic Proceedings, vol. 77, no. 9, 2002, pp. 910-2.
    Nyquist PA, Cascino GD, McClelland RL, et al. Incidence of seizures in patients with multiple sclerosis: a population-based study. Mayo Clin Proc. 2002;77(9):910-2.
    Nyquist, P. A., Cascino, G. D., McClelland, R. L., Annegers, J. F., & Rodriguez, M. (2002). Incidence of seizures in patients with multiple sclerosis: a population-based study. Mayo Clinic Proceedings, 77(9), pp. 910-2.
    Nyquist PA, et al. Incidence of Seizures in Patients With Multiple Sclerosis: a Population-based Study. Mayo Clin Proc. 2002;77(9):910-2. PubMed PMID: 12233923.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Incidence of seizures in patients with multiple sclerosis: a population-based study. AU - Nyquist,Paul A, AU - Cascino,Gregory D, AU - McClelland,Robyn L, AU - Annegers,John F, AU - Rodriguez,Moses, PY - 2002/9/18/pubmed PY - 2002/10/22/medline PY - 2002/9/18/entrez SP - 910 EP - 2 JF - Mayo Clinic proceedings JO - Mayo Clin. Proc. VL - 77 IS - 9 N2 - OBJECTIVE: To determine whether multiple sclerosis (MS) is associated with occurrence of seizure activity. PATIENTS AND METHODS: The medical records of all incidence patients with MS in Olmsted County, Minnesota, from 1935 to 1991 were reviewed. The incidence of seizures was calculated by using 3 methods: including only seizures that occurred after definite diagnosis of MS, including all seizures occurring after onset of the first symptoms of MS, and including any seizures regardless of the time of onset relative to MS. These incidences were age-adjusted to the 1970 US population and then compared with the age-adjusted incidence rate of seizures in the general population of Olmsted County. RESULTS: The age-adjusted incidence of seizures among MS patients was not significantly higher than the age-adjusted incidence of seizures in the general population of Olmsted County. The age-adjusted incidence of first unprovoked seizures in Rochester, Minn, was 61 per 100,000 person-years. In patients with the definite diagnosis of MS, the age-adjusted Incidence was calculated at 61 per 100,000 person-years (95% confidence interval [CI], 7-114). In the group with seizures after onset of symptoms, the age-adjusted incidence rate was 80 per 100,000 person-years (95% CI, 24-135). In the group with seizures at any time in their life, the age-adjusted incidence rate was 82 per 100,000 person-years (95% CI, 41-158). CONCLUSION: The present study does not suggest that occurrence of seizures is more common in MS patients than in the general population. SN - 0025-6196 UR - https://www.unboundmedicine.com/medline/citation/12233923/Incidence_of_seizures_in_patients_with_multiple_sclerosis:_a_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(11)62257-X DB - PRIME DP - Unbound Medicine ER -