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Role of the nitric oxide pathway in kappa-opioid-induced hypothermia in rats.
J Pharmacol Exp Ther. 2002 Oct; 303(1):375-8.JP

Abstract

The effect of central and peripheral administration of a nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on the hypothermia induced by the selective kappa-opioid receptor agonist trans-(+/-)3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]-cyclohexyl)-benzeneacetamide methane sulfate (U50,488H) was studied in male Sprague-Dawley rats. In the first series of experiments, we examined the effect of subcutaneous (s.c.) administration of L-NAME on the hypothermia induced by s.c. injection of U50,488H. L-NAME, at a dose of 50 mg/kg s.c., had no influence on body temperature (Tb). Coadministration of L-NAME (50 mg/kg, s.c.) with U50,488H (10 mg/kg, s.c.) blocked the hypothermia induced by U50,488H. In the second series of experiments, we investigated the effect of intracerebroventricular (i.c.v.) administration of L-NAME on the hypothermia induced by s.c. injection of U50,488H. L-NAME itself, given i.c.v. at a dose of 1 mg/rat, did not evoke any change in Tb. Administration of L-NAME (1 mg/rat, i.c.v.) caused a significant suppression of U50,488H hypothermia. The results indicate that either central or peripheral nitric oxide synthesis is required for the production of hypothermia induced by U50,488H.

Authors+Show Affiliations

Center for Substance Abuse Research and Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. kbenamar@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12235273

Citation

Benamar, Khalid, et al. "Role of the Nitric Oxide Pathway in Kappa-opioid-induced Hypothermia in Rats." The Journal of Pharmacology and Experimental Therapeutics, vol. 303, no. 1, 2002, pp. 375-8.
Benamar K, Geller EB, Adler MW. Role of the nitric oxide pathway in kappa-opioid-induced hypothermia in rats. J Pharmacol Exp Ther. 2002;303(1):375-8.
Benamar, K., Geller, E. B., & Adler, M. W. (2002). Role of the nitric oxide pathway in kappa-opioid-induced hypothermia in rats. The Journal of Pharmacology and Experimental Therapeutics, 303(1), 375-8.
Benamar K, Geller EB, Adler MW. Role of the Nitric Oxide Pathway in Kappa-opioid-induced Hypothermia in Rats. J Pharmacol Exp Ther. 2002;303(1):375-8. PubMed PMID: 12235273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the nitric oxide pathway in kappa-opioid-induced hypothermia in rats. AU - Benamar,Khalid, AU - Geller,Ellen B, AU - Adler,Martin W, PY - 2002/9/18/pubmed PY - 2002/10/22/medline PY - 2002/9/18/entrez SP - 375 EP - 8 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 303 IS - 1 N2 - The effect of central and peripheral administration of a nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on the hypothermia induced by the selective kappa-opioid receptor agonist trans-(+/-)3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]-cyclohexyl)-benzeneacetamide methane sulfate (U50,488H) was studied in male Sprague-Dawley rats. In the first series of experiments, we examined the effect of subcutaneous (s.c.) administration of L-NAME on the hypothermia induced by s.c. injection of U50,488H. L-NAME, at a dose of 50 mg/kg s.c., had no influence on body temperature (Tb). Coadministration of L-NAME (50 mg/kg, s.c.) with U50,488H (10 mg/kg, s.c.) blocked the hypothermia induced by U50,488H. In the second series of experiments, we investigated the effect of intracerebroventricular (i.c.v.) administration of L-NAME on the hypothermia induced by s.c. injection of U50,488H. L-NAME itself, given i.c.v. at a dose of 1 mg/rat, did not evoke any change in Tb. Administration of L-NAME (1 mg/rat, i.c.v.) caused a significant suppression of U50,488H hypothermia. The results indicate that either central or peripheral nitric oxide synthesis is required for the production of hypothermia induced by U50,488H. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/12235273/Role_of_the_nitric_oxide_pathway_in_kappa_opioid_induced_hypothermia_in_rats_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=12235273 DB - PRIME DP - Unbound Medicine ER -