Tags

Type your tag names separated by a space and hit enter

Rapid hematopoietic engraftment following fractionated TBI conditioning and transplantation with CD34(+) enriched hematopoietic progenitor cells from partially mismatched related donors.
Bone Marrow Transplant. 2002 Sep; 30(6):335-40.BM

Abstract

Nineteen adult patients with poor-risk hematologic malignancy received T cell-depleted (TCD) hematopoietic progenitor cell (HPC) transplant from partially mismatched related donors (PMRD). The preparative regimen (FITFA) included fractionated TBI, thiotepa, fludarabine, and horse (n = 3) or rabbit (n = 16) anti-thymocyte anti-sera (ATG). GVHD prophylaxis consisted of TCD by positive/negative selection using the Isolex 300i system and pre-transplant ATG with no post-transplant immunosuppression. The mean number (+/-s.d.) of transplanted CD34(+) and CD3(+) cells were 8.9 x 10(6)/kg +/-4.3 (range 2.6-19.3) and 1.4 x 10(4)/kg +/-1.2 (range 0.3-4.6) respectively. Seventeen patients evaluable for neutrophil engraftment achieved an ANC >0.5 x 10(9)/l at a median of 12 days (range 9-27), with evidence of full donor chimerism. Thirteen patients died of the following causes: relapse (n = 6), infections (n = 5), interstitial pneumonia (n = 1), and unknown causes (n = 1) None of the recipients of rabbit ATG required therapy for acute or chronic GVHD. Five patients are alive and disease-free at a median time of 303 days post transplant (range 100-660). The FITFA preparative regimen using fractionated TBI is well tolerated and is sufficiently immunosuppressive to allow rapid and stable donor origin hematopoietic engraftment without 'mega' doses of CD34(+) cells. Combination of stringent ex vivo TCD and pre-transplant ATG is effective GVHD prophylaxis.

Authors+Show Affiliations

Emory University School of Medicine, Winship Cancer Institute, Department of Hematology and Oncology, Bone Marrow and Stem Cell Transplant Center, Emory University, Atlanta, GA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

12235516

Citation

Redei, I, et al. "Rapid Hematopoietic Engraftment Following Fractionated TBI Conditioning and Transplantation With CD34(+) Enriched Hematopoietic Progenitor Cells From Partially Mismatched Related Donors." Bone Marrow Transplantation, vol. 30, no. 6, 2002, pp. 335-40.
Redei I, Langston AA, Lonial S, et al. Rapid hematopoietic engraftment following fractionated TBI conditioning and transplantation with CD34(+) enriched hematopoietic progenitor cells from partially mismatched related donors. Bone Marrow Transplant. 2002;30(6):335-40.
Redei, I., Langston, A. A., Lonial, S., Cherry, J. K., Allen, A. J., Hamilton, E., Jones, M., Bartlett, V. M., & Waller, E. K. (2002). Rapid hematopoietic engraftment following fractionated TBI conditioning and transplantation with CD34(+) enriched hematopoietic progenitor cells from partially mismatched related donors. Bone Marrow Transplantation, 30(6), 335-40.
Redei I, et al. Rapid Hematopoietic Engraftment Following Fractionated TBI Conditioning and Transplantation With CD34(+) Enriched Hematopoietic Progenitor Cells From Partially Mismatched Related Donors. Bone Marrow Transplant. 2002;30(6):335-40. PubMed PMID: 12235516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid hematopoietic engraftment following fractionated TBI conditioning and transplantation with CD34(+) enriched hematopoietic progenitor cells from partially mismatched related donors. AU - Redei,I, AU - Langston,A A, AU - Lonial,S, AU - Cherry,J K, AU - Allen,A J, AU - Hamilton,E, AU - Jones,M, AU - Bartlett,V M, AU - Waller,E K, PY - 2002/01/15/received PY - 2002/04/18/accepted PY - 2002/9/18/pubmed PY - 2003/7/3/medline PY - 2002/9/18/entrez SP - 335 EP - 40 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 30 IS - 6 N2 - Nineteen adult patients with poor-risk hematologic malignancy received T cell-depleted (TCD) hematopoietic progenitor cell (HPC) transplant from partially mismatched related donors (PMRD). The preparative regimen (FITFA) included fractionated TBI, thiotepa, fludarabine, and horse (n = 3) or rabbit (n = 16) anti-thymocyte anti-sera (ATG). GVHD prophylaxis consisted of TCD by positive/negative selection using the Isolex 300i system and pre-transplant ATG with no post-transplant immunosuppression. The mean number (+/-s.d.) of transplanted CD34(+) and CD3(+) cells were 8.9 x 10(6)/kg +/-4.3 (range 2.6-19.3) and 1.4 x 10(4)/kg +/-1.2 (range 0.3-4.6) respectively. Seventeen patients evaluable for neutrophil engraftment achieved an ANC >0.5 x 10(9)/l at a median of 12 days (range 9-27), with evidence of full donor chimerism. Thirteen patients died of the following causes: relapse (n = 6), infections (n = 5), interstitial pneumonia (n = 1), and unknown causes (n = 1) None of the recipients of rabbit ATG required therapy for acute or chronic GVHD. Five patients are alive and disease-free at a median time of 303 days post transplant (range 100-660). The FITFA preparative regimen using fractionated TBI is well tolerated and is sufficiently immunosuppressive to allow rapid and stable donor origin hematopoietic engraftment without 'mega' doses of CD34(+) cells. Combination of stringent ex vivo TCD and pre-transplant ATG is effective GVHD prophylaxis. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/12235516/Rapid_hematopoietic_engraftment_following_fractionated_TBI_conditioning_and_transplantation_with_CD34_+__enriched_hematopoietic_progenitor_cells_from_partially_mismatched_related_donors_ L2 - https://doi.org/10.1038/sj.bmt.1703649 DB - PRIME DP - Unbound Medicine ER -