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Mortality and causes of death in patients with "lupoid hepatitis." A long-term follow-up study in Denmark.
Dan Med Bull. 2002 Aug; 49(3):263-5.DM

Abstract

BACKGROUND

The mortality and causes of death in patients with "lupoid hepatitis", corresponding to the recent term autoimmune hepatitis, have rarely been reported.

METHODS

We identified all patients discharged from hospital with a diagnosis of "lupoid hepatitis" from 1 January 1977 until 31 December 1993 in the Danish National Registry of Patients. The causes of death for the cohort were determined by linkage of the personal identification number with the Danish Death Registry. The cohort was followed until 31 December 1996. The expected number of deaths was estimated from the national age, sex, calendar period and cause-specific death rates; and the standardised mortality ratio was calculated.

RESULTS

We identified a total of 96 patients. The mean age was 50 years, and 71% of the patients were female. The mean follow-up period was 7.5 years, and after 12 years of follow-up, 50% of the patients were still alive. The overall standardised mortality ratio was 3.7 (95% CI, 2.7-5.0). The risk of dying from liver cirrhosis was increased 51.2-fold (95% CI, 22.1-100.9) compared with the general population.

CONCLUSIONS

Patients with "lupoid hepatitis" have a reduced life expectancy, mainly caused by excess deaths from liver cirrhosis, malignancy and heart disease.

Authors+Show Affiliations

Poulsen LO
Department of Clinical Epidemiology, Aarhus University Hospital and Aalborg Hospital, Vennelyst Boulevard 6, DK-8000 Aarhus C, Denmark.
Thulstrup AM
No affiliation info available
Mellemkjaer L
No affiliation info available
Vilstrup H
No affiliation info available
Sørensen HT
No affiliation info available

MeSH

Cause of DeathDenmarkFemaleFollow-Up StudiesHepatitis, AutoimmuneHumansMaleMiddle AgedSurvival Rate

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12238290

Citation

Poulsen, Lene Overgaard, et al. "Mortality and Causes of Death in Patients With "lupoid Hepatitis." a Long-term Follow-up Study in Denmark." Danish Medical Bulletin, vol. 49, no. 3, 2002, pp. 263-5.
Poulsen LO, Thulstrup AM, Mellemkjaer L, et al. Mortality and causes of death in patients with "lupoid hepatitis." A long-term follow-up study in Denmark. Dan Med Bull. 2002;49(3):263-5.
Poulsen, L. O., Thulstrup, A. M., Mellemkjaer, L., Vilstrup, H., & Sørensen, H. T. (2002). Mortality and causes of death in patients with "lupoid hepatitis." A long-term follow-up study in Denmark. Danish Medical Bulletin, 49(3), 263-5.
Poulsen LO, et al. Mortality and Causes of Death in Patients With "lupoid Hepatitis." a Long-term Follow-up Study in Denmark. Dan Med Bull. 2002;49(3):263-5. PubMed PMID: 12238290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mortality and causes of death in patients with "lupoid hepatitis." A long-term follow-up study in Denmark. AU - Poulsen,Lene Overgaard, AU - Thulstrup,Ane Marie, AU - Mellemkjaer,Lene, AU - Vilstrup,Hendrik, AU - Sørensen,Henrik Toft, PY - 2002/9/20/pubmed PY - 2003/1/24/medline PY - 2002/9/20/entrez SP - 263 EP - 5 JF - Danish medical bulletin JO - Dan Med Bull VL - 49 IS - 3 N2 - BACKGROUND: The mortality and causes of death in patients with "lupoid hepatitis", corresponding to the recent term autoimmune hepatitis, have rarely been reported. METHODS: We identified all patients discharged from hospital with a diagnosis of "lupoid hepatitis" from 1 January 1977 until 31 December 1993 in the Danish National Registry of Patients. The causes of death for the cohort were determined by linkage of the personal identification number with the Danish Death Registry. The cohort was followed until 31 December 1996. The expected number of deaths was estimated from the national age, sex, calendar period and cause-specific death rates; and the standardised mortality ratio was calculated. RESULTS: We identified a total of 96 patients. The mean age was 50 years, and 71% of the patients were female. The mean follow-up period was 7.5 years, and after 12 years of follow-up, 50% of the patients were still alive. The overall standardised mortality ratio was 3.7 (95% CI, 2.7-5.0). The risk of dying from liver cirrhosis was increased 51.2-fold (95% CI, 22.1-100.9) compared with the general population. CONCLUSIONS: Patients with "lupoid hepatitis" have a reduced life expectancy, mainly caused by excess deaths from liver cirrhosis, malignancy and heart disease. SN - 0907-8916 UR - https://www.unboundmedicine.com/medline/citation/12238290/Mortality_and_causes_of_death_in_patients_with_"lupoid_hepatitis_"_A_long_term_follow_up_study_in_Denmark_ DB - PRIME DP - Unbound Medicine ER -