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Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus.
Antivir Chem Chemother. 2002 Mar; 13(2):83-9.AC

Abstract

A novel series of DL-galactan hybrids extracted from the red seaweed Gymnogongrus torulosus, was evaluated for its in vitro antiviral properties against herpes simplex virus type 2 (HSV-2) and dengue virus 2 (DEN-2). These compounds were very active against both viruses with inhibitory concentration 50% (IC50) values in the range 0.6-16 microg/ml for HSV-2 and 0.19-1.7 microg/ml for DEN-2, respectively, as determined in a virus plaque reduction assay in Vero cells. The DL-galactans lacked of cytotoxic effects, on stationary as well as on actively dividing cells, and anticoagulant properties. Some of the compounds showed a variable level of direct inactivating effect on both virions, with virucidal concentration 50% values exceeding the IC50s obtained by plaque reduction assay. Full inhibitory activity was achieved when the galactans were present during virus adsorption period, suggesting that the mode of action of these compounds is an interference in the binding of the surface envelope glycoprotein with the cell receptor.

Authors+Show Affiliations

Departamento de Quimica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12238532

Citation

Pujol, C A., et al. "Novel DL-galactan Hybrids From the Red Seaweed Gymnogongrus Torulosus Are Potent Inhibitors of Herpes Simplex Virus and Dengue Virus." Antiviral Chemistry & Chemotherapy, vol. 13, no. 2, 2002, pp. 83-9.
Pujol CA, Estevez JM, Carlucci MJ, et al. Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus. Antivir Chem Chemother. 2002;13(2):83-9.
Pujol, C. A., Estevez, J. M., Carlucci, M. J., Ciancia, M., Cerezo, A. S., & Damonte, E. B. (2002). Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus. Antiviral Chemistry & Chemotherapy, 13(2), 83-9.
Pujol CA, et al. Novel DL-galactan Hybrids From the Red Seaweed Gymnogongrus Torulosus Are Potent Inhibitors of Herpes Simplex Virus and Dengue Virus. Antivir Chem Chemother. 2002;13(2):83-9. PubMed PMID: 12238532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus. AU - Pujol,C A, AU - Estevez,J M, AU - Carlucci,M J, AU - Ciancia,M, AU - Cerezo,A S, AU - Damonte,E B, PY - 2002/9/20/pubmed PY - 2003/6/6/medline PY - 2002/9/20/entrez SP - 83 EP - 9 JF - Antiviral chemistry & chemotherapy JO - Antivir Chem Chemother VL - 13 IS - 2 N2 - A novel series of DL-galactan hybrids extracted from the red seaweed Gymnogongrus torulosus, was evaluated for its in vitro antiviral properties against herpes simplex virus type 2 (HSV-2) and dengue virus 2 (DEN-2). These compounds were very active against both viruses with inhibitory concentration 50% (IC50) values in the range 0.6-16 microg/ml for HSV-2 and 0.19-1.7 microg/ml for DEN-2, respectively, as determined in a virus plaque reduction assay in Vero cells. The DL-galactans lacked of cytotoxic effects, on stationary as well as on actively dividing cells, and anticoagulant properties. Some of the compounds showed a variable level of direct inactivating effect on both virions, with virucidal concentration 50% values exceeding the IC50s obtained by plaque reduction assay. Full inhibitory activity was achieved when the galactans were present during virus adsorption period, suggesting that the mode of action of these compounds is an interference in the binding of the surface envelope glycoprotein with the cell receptor. SN - 0956-3202 UR - https://www.unboundmedicine.com/medline/citation/12238532/Novel_DL_galactan_hybrids_from_the_red_seaweed_Gymnogongrus_torulosus_are_potent_inhibitors_of_herpes_simplex_virus_and_dengue_virus_ DB - PRIME DP - Unbound Medicine ER -