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Two hour plasma glucose is not unequivocally predictive for early death in men with impaired fasting glucose: more results from the Paris Prospective Study.
Diabetologia. 2002 Sep; 45(9):1224-30.D

Abstract

AIMS/HYPOTHESIS

We examined whether the 2-h plasma glucose (2 hPG) concentration after a 75 g OGTT is predictive of death in men with a diabetic, an impaired or a normal fasting plasma glucose concentration (DM-FPG: > or =7.0 mmol/l; IFG: 6.1-6.9 mmol/l; normal-FPG: <6.1 mmol/l).

METHODS

The 17-year mortality of 7018 men, aged 44 to 55 years, from the Paris Prospective Study, who were not known to be diabetic at baseline was studied.

RESULTS

The 2 hPG was not associated with early mortality in men with a DM-FPG in contrast to men with an IFG or a normal-FPG; for an increase from 10 to 11 mmol/l in the 2 hPG, the age-adjusted hazards ratios were 1.01 (95% CI 0.95-1.08), 1.15 (1.03-1.28) and 1.24 (1.18-1.31) respectively. Coronary heart disease mortality and within this category sudden death but not ischaemic heart disease death, were related with 2 hPG but only in the men with normal FPG. However, the prediction by 2 hPG did not differ between the men with DM-FPG, an IFG or a normal-FPG: the overall age-adjusted hazards ratios for these three causes of death were 1.09 (1.00-1.18), 1.13 (1.02-1.26) and 1.13 (0.99-1.29), respectively.

CONCLUSION/INTERPRETATION

2 hPG is unequivocally prognostic for all-cause mortality only in men with normal FPG. Screening men with an IFG by using a 75 g OGTT is of limited benefit.

Authors+Show Affiliations

INSERM U258-IFR69 and Faculty of Medicine University Paris XI, Villejuif, France. balkau@vjf.inserm.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12242454

Citation

Balkau, B, et al. "Two Hour Plasma Glucose Is Not Unequivocally Predictive for Early Death in Men With Impaired Fasting Glucose: More Results From the Paris Prospective Study." Diabetologia, vol. 45, no. 9, 2002, pp. 1224-30.
Balkau B, Forhan A, Eschwège E. Two hour plasma glucose is not unequivocally predictive for early death in men with impaired fasting glucose: more results from the Paris Prospective Study. Diabetologia. 2002;45(9):1224-30.
Balkau, B., Forhan, A., & Eschwège, E. (2002). Two hour plasma glucose is not unequivocally predictive for early death in men with impaired fasting glucose: more results from the Paris Prospective Study. Diabetologia, 45(9), 1224-30.
Balkau B, Forhan A, Eschwège E. Two Hour Plasma Glucose Is Not Unequivocally Predictive for Early Death in Men With Impaired Fasting Glucose: More Results From the Paris Prospective Study. Diabetologia. 2002;45(9):1224-30. PubMed PMID: 12242454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two hour plasma glucose is not unequivocally predictive for early death in men with impaired fasting glucose: more results from the Paris Prospective Study. AU - Balkau,B, AU - Forhan,A, AU - Eschwège,E, Y1 - 2002/07/06/ PY - 2002/02/28/received PY - 2002/04/24/revised PY - 2002/9/21/pubmed PY - 2003/4/16/medline PY - 2002/9/21/entrez SP - 1224 EP - 30 JF - Diabetologia JO - Diabetologia VL - 45 IS - 9 N2 - AIMS/HYPOTHESIS: We examined whether the 2-h plasma glucose (2 hPG) concentration after a 75 g OGTT is predictive of death in men with a diabetic, an impaired or a normal fasting plasma glucose concentration (DM-FPG: > or =7.0 mmol/l; IFG: 6.1-6.9 mmol/l; normal-FPG: <6.1 mmol/l). METHODS: The 17-year mortality of 7018 men, aged 44 to 55 years, from the Paris Prospective Study, who were not known to be diabetic at baseline was studied. RESULTS: The 2 hPG was not associated with early mortality in men with a DM-FPG in contrast to men with an IFG or a normal-FPG; for an increase from 10 to 11 mmol/l in the 2 hPG, the age-adjusted hazards ratios were 1.01 (95% CI 0.95-1.08), 1.15 (1.03-1.28) and 1.24 (1.18-1.31) respectively. Coronary heart disease mortality and within this category sudden death but not ischaemic heart disease death, were related with 2 hPG but only in the men with normal FPG. However, the prediction by 2 hPG did not differ between the men with DM-FPG, an IFG or a normal-FPG: the overall age-adjusted hazards ratios for these three causes of death were 1.09 (1.00-1.18), 1.13 (1.02-1.26) and 1.13 (0.99-1.29), respectively. CONCLUSION/INTERPRETATION: 2 hPG is unequivocally prognostic for all-cause mortality only in men with normal FPG. Screening men with an IFG by using a 75 g OGTT is of limited benefit. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/12242454/Two_hour_plasma_glucose_is_not_unequivocally_predictive_for_early_death_in_men_with_impaired_fasting_glucose:_more_results_from_the_Paris_Prospective_Study_ L2 - https://doi.org/10.1007/s00125-002-0889-3 DB - PRIME DP - Unbound Medicine ER -