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Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats.
J Biochem Mol Toxicol. 2002; 16(4):197-202.JB

Abstract

Reactive oxygen species may be actively involved in the genesis of various pathological states such as ischemia-reperfusion injury, cancer, and diabetes. Our objective was to determine if subacute treatment with combined antioxidants quercetin and coenzyme Q(10) (10 mg/kg/day ip for 14 days) affects the activities of antioxidant enzymes in normal and 30-day streptozotocin-induced diabetic Sprague-Dawley rats. Quercetin treatment raised blood glucose concentrations in normal and diabetic rats, whereas treatment with coenzyme Q(10) did not. Liver, kidney, heart, and brain tissues were excised and the activities of catalase, glutathione reductase, glutathione peroxidase, superoxide dismutase, and concentrations of oxidized and reduced glutathione were determined. In the liver of diabetic rats, superoxide dismutase, glutathione peroxidase, and levels of both oxidized and reduced glutathione were significantly decreased from the nondiabetic control, and these effects were not reversed when antioxidants were administered. In kidney, glutathione peroxidase activity was significantly elevated in the diabetic rats as compared to nondiabetic rats, and antioxidant treatment did not return the enzyme activity to nondiabetic levels. In heart, catalase activity was increased in diabetic animals and restored to normal levels after combined treatment with quercetin and coenzyme Q(10). Cardiac superoxide dismutase was lower than normal in quercetin- and quercetin + coenzyme Q(10)-treated diabetic rats. There were no adverse effects on oxidative stress markers after treatment with quercetin or coenzyme Q(10) singly or in combination. In spite of the elevation of glucose, quercetin may be effective in reversing some effects of diabetes, but the combination of quercetin + coenzyme Q(10) did not increase effectiveness in reversing effects of diabetes.

Authors+Show Affiliations

Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana 47405-7005, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12242689

Citation

Coldiron, Allan D., et al. "Effects of Combined Quercetin and Coenzyme Q(10) Treatment On Oxidative Stress in Normal and Diabetic Rats." Journal of Biochemical and Molecular Toxicology, vol. 16, no. 4, 2002, pp. 197-202.
Coldiron AD, Sanders RA, Watkins JB. Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. J Biochem Mol Toxicol. 2002;16(4):197-202.
Coldiron, A. D., Sanders, R. A., & Watkins, J. B. (2002). Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. Journal of Biochemical and Molecular Toxicology, 16(4), 197-202.
Coldiron AD, Sanders RA, Watkins JB. Effects of Combined Quercetin and Coenzyme Q(10) Treatment On Oxidative Stress in Normal and Diabetic Rats. J Biochem Mol Toxicol. 2002;16(4):197-202. PubMed PMID: 12242689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. AU - Coldiron,Allan D,Jr AU - Sanders,Ruth A, AU - Watkins,John B,3rd PY - 2002/9/21/pubmed PY - 2003/3/5/medline PY - 2002/9/21/entrez SP - 197 EP - 202 JF - Journal of biochemical and molecular toxicology JO - J Biochem Mol Toxicol VL - 16 IS - 4 N2 - Reactive oxygen species may be actively involved in the genesis of various pathological states such as ischemia-reperfusion injury, cancer, and diabetes. Our objective was to determine if subacute treatment with combined antioxidants quercetin and coenzyme Q(10) (10 mg/kg/day ip for 14 days) affects the activities of antioxidant enzymes in normal and 30-day streptozotocin-induced diabetic Sprague-Dawley rats. Quercetin treatment raised blood glucose concentrations in normal and diabetic rats, whereas treatment with coenzyme Q(10) did not. Liver, kidney, heart, and brain tissues were excised and the activities of catalase, glutathione reductase, glutathione peroxidase, superoxide dismutase, and concentrations of oxidized and reduced glutathione were determined. In the liver of diabetic rats, superoxide dismutase, glutathione peroxidase, and levels of both oxidized and reduced glutathione were significantly decreased from the nondiabetic control, and these effects were not reversed when antioxidants were administered. In kidney, glutathione peroxidase activity was significantly elevated in the diabetic rats as compared to nondiabetic rats, and antioxidant treatment did not return the enzyme activity to nondiabetic levels. In heart, catalase activity was increased in diabetic animals and restored to normal levels after combined treatment with quercetin and coenzyme Q(10). Cardiac superoxide dismutase was lower than normal in quercetin- and quercetin + coenzyme Q(10)-treated diabetic rats. There were no adverse effects on oxidative stress markers after treatment with quercetin or coenzyme Q(10) singly or in combination. In spite of the elevation of glucose, quercetin may be effective in reversing some effects of diabetes, but the combination of quercetin + coenzyme Q(10) did not increase effectiveness in reversing effects of diabetes. SN - 1095-6670 UR - https://www.unboundmedicine.com/medline/citation/12242689/Effects_of_combined_quercetin_and_coenzyme_Q_10__treatment_on_oxidative_stress_in_normal_and_diabetic_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1095-6670&date=2002&volume=16&issue=4&spage=197 DB - PRIME DP - Unbound Medicine ER -