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The effect of somatostatin on plasma insulin and growth hormone levels in basal conditions and after glucagon in normal and acromegalic subjects.
Acta Diabetol Lat. 1975 May-Aug; 12(3-4):219-31.AD

Abstract

The effect of low-dose somatostatin (2.5 mug/min i.v.) on blood sugar, insulin and GH levels (basal and after i.v. 1 mg glucagon) was studied in 7 normal and 10 acromegalic subjects. No changes in basal values were noted in normal subjects, whereas the insulin response to glucagon was partly inhibited and the glucose response enhanced. Basal blood glucose was likewise unaltered in the acromegalics. There was, however, a significant, though unrelated, fall in both insulin and GH. The insulin response to glucagon was inhibited to a greater degree than in normal subjects. It is clear, therefore, that somatostatin can inhibit the insulin response to glucagon, as well as that to the other stimuli for which data are given in the literature. Acromegalic subjects appear to be more sensitive to inhibition of insulin secretion by somatostatin, though no relation between this and the drug's parallel inhibition of GH secretion can be shown.

Authors

Massara F
No affiliation info available
Porzio G
No affiliation info available
Camanni F
No affiliation info available
Molinatti GM
No affiliation info available

MeSH

AcromegalyAdultFemaleGlucagonGrowth HormoneHumansIn Vitro TechniquesInsulinMaleSomatostatin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1224905

Citation

Massara, F, et al. "The Effect of Somatostatin On Plasma Insulin and Growth Hormone Levels in Basal Conditions and After Glucagon in Normal and Acromegalic Subjects." Acta Diabetologica Latina, vol. 12, no. 3-4, 1975, pp. 219-31.
Massara F, Porzio G, Camanni F, et al. The effect of somatostatin on plasma insulin and growth hormone levels in basal conditions and after glucagon in normal and acromegalic subjects. Acta Diabetol Lat. 1975;12(3-4):219-31.
Massara, F., Porzio, G., Camanni, F., & Molinatti, G. M. (1975). The effect of somatostatin on plasma insulin and growth hormone levels in basal conditions and after glucagon in normal and acromegalic subjects. Acta Diabetologica Latina, 12(3-4), 219-31.
Massara F, et al. The Effect of Somatostatin On Plasma Insulin and Growth Hormone Levels in Basal Conditions and After Glucagon in Normal and Acromegalic Subjects. Acta Diabetol Lat. 1975 May-Aug;12(3-4):219-31. PubMed PMID: 1224905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of somatostatin on plasma insulin and growth hormone levels in basal conditions and after glucagon in normal and acromegalic subjects. AU - Massara,F, AU - Porzio,G, AU - Camanni,F, AU - Molinatti,G M, PY - 1975/5/1/pubmed PY - 1975/5/1/medline PY - 1975/5/1/entrez SP - 219 EP - 31 JF - Acta diabetologica latina JO - Acta Diabetol Lat VL - 12 IS - 3-4 N2 - The effect of low-dose somatostatin (2.5 mug/min i.v.) on blood sugar, insulin and GH levels (basal and after i.v. 1 mg glucagon) was studied in 7 normal and 10 acromegalic subjects. No changes in basal values were noted in normal subjects, whereas the insulin response to glucagon was partly inhibited and the glucose response enhanced. Basal blood glucose was likewise unaltered in the acromegalics. There was, however, a significant, though unrelated, fall in both insulin and GH. The insulin response to glucagon was inhibited to a greater degree than in normal subjects. It is clear, therefore, that somatostatin can inhibit the insulin response to glucagon, as well as that to the other stimuli for which data are given in the literature. Acromegalic subjects appear to be more sensitive to inhibition of insulin secretion by somatostatin, though no relation between this and the drug's parallel inhibition of GH secretion can be shown. SN - 0001-5563 UR - https://www.unboundmedicine.com/medline/citation/1224905/The_effect_of_somatostatin_on_plasma_insulin_and_growth_hormone_levels_in_basal_conditions_and_after_glucagon_in_normal_and_acromegalic_subjects_ DB - PRIME DP - Unbound Medicine ER -