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Efficacy of a complex multivitamin supplement.

Abstract

OBJECTIVES

Multivitamin supplements are often sold to consumers with the claim that supplements modify risk factors associated with disease. Because few products are validated scientifically, we examined the effects of a 24-ingredient multivitamin formula in an open-label pilot investigation.

METHODS

We examined 150 subjects for specific endpoints including blood concentrations of selected vitamins, homocysteine, lipids, and low-density lipoprotein (LDL) oxidation indices at baseline and at 12 and 24 wk.

RESULTS

One hundred forty-one subjects were successfully assayed for and showed significant time effects for homocysteine and vitamin B6 (as pyridoxal-5'-phosphate), B12, and folic acid concentrations during treatment (P < 0.0001). Vitamin B6, B12, and folic acid concentrations were significantly elevated at weeks 12 and 24 (P < 0.05). Homocysteine concentration decreased significantly during the same periods (7.9 +/- 2.4 versus 6.7 +/- 1.7 versus 6.7 +/- 1.9 mM/mL; P < 0.05). There were correlations relating homocysteine to vitamins B6 (P = 0.001, r(2) = 0.03), B12 (P < 0.001, r(2) = 0.09), and folic acid (P = 0.001, r(2) = 0.10). Significant time effects were noted for 121 subjects successfully assayed for vitamin C, E, beta-carotene, LDL oxidation rate, and LDL lag time (P < 0.0001). Post hoc assessment showed elevations in vitamin C, E, and beta-carotene concentrations at 12 and 24 wk (P < 0.05). LDL oxidation lag time at baseline (57.5 +/- 13.9 min) increased by 12 wk (63.5 +/- 19.0 min; P < 0.05) and 24 wk (63.8 +/- 16.3 min; P < 0.05). LDL oxidation rate at baseline (9.7 +/- 3.0 microM x min(-1). g(-1)) was reduced at 12 wk (7.1 +/- 2.5 microM x min(-1) x g(-1); P < 0.05) and 24 wk (6.0 +/- 2.0 microM x min(-1) x g(-1); P < 0.05). Only vitamin C was significantly correlated with LDL oxidation rate (P = 0.05, r(2) = 0.003).

CONCLUSIONS

A multi-ingredient vitamin formula with antioxidant properties has measurable effects on homocysteine and LDL oxidation indices.

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  • Authors+Show Affiliations

    ,

    The Cooper Institute for Aerobics Research, Dallas, Texas 75230, USA. cearnest@cooperinst.org

    , ,

    Source

    MeSH

    Adult
    Aged
    Antioxidants
    Ascorbic Acid
    Cohort Studies
    Dietary Supplements
    Female
    Folic Acid
    Homocysteine
    Humans
    Lipid Peroxidation
    Lipoproteins, LDL
    Male
    Middle Aged
    Oxidation-Reduction
    Pilot Projects
    Pyridoxal Phosphate
    Pyridoxine
    Vitamin B 12
    Vitamin E
    Vitamins
    beta Carotene

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12297209

    Citation

    Earnest, Conrad, et al. "Efficacy of a Complex Multivitamin Supplement." Nutrition (Burbank, Los Angeles County, Calif.), vol. 18, no. 9, 2002, pp. 738-42.
    Earnest C, Cooper KH, Marks A, et al. Efficacy of a complex multivitamin supplement. Nutrition. 2002;18(9):738-42.
    Earnest, C., Cooper, K. H., Marks, A., & Mitchell, T. L. (2002). Efficacy of a complex multivitamin supplement. Nutrition (Burbank, Los Angeles County, Calif.), 18(9), pp. 738-42.
    Earnest C, et al. Efficacy of a Complex Multivitamin Supplement. Nutrition. 2002;18(9):738-42. PubMed PMID: 12297209.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Efficacy of a complex multivitamin supplement. AU - Earnest,Conrad, AU - Cooper,Kenneth H, AU - Marks,Angela, AU - Mitchell,Tedd L, PY - 2002/9/26/pubmed PY - 2003/1/29/medline PY - 2002/9/26/entrez SP - 738 EP - 42 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 18 IS - 9 N2 - OBJECTIVES: Multivitamin supplements are often sold to consumers with the claim that supplements modify risk factors associated with disease. Because few products are validated scientifically, we examined the effects of a 24-ingredient multivitamin formula in an open-label pilot investigation. METHODS: We examined 150 subjects for specific endpoints including blood concentrations of selected vitamins, homocysteine, lipids, and low-density lipoprotein (LDL) oxidation indices at baseline and at 12 and 24 wk. RESULTS: One hundred forty-one subjects were successfully assayed for and showed significant time effects for homocysteine and vitamin B6 (as pyridoxal-5'-phosphate), B12, and folic acid concentrations during treatment (P < 0.0001). Vitamin B6, B12, and folic acid concentrations were significantly elevated at weeks 12 and 24 (P < 0.05). Homocysteine concentration decreased significantly during the same periods (7.9 +/- 2.4 versus 6.7 +/- 1.7 versus 6.7 +/- 1.9 mM/mL; P < 0.05). There were correlations relating homocysteine to vitamins B6 (P = 0.001, r(2) = 0.03), B12 (P < 0.001, r(2) = 0.09), and folic acid (P = 0.001, r(2) = 0.10). Significant time effects were noted for 121 subjects successfully assayed for vitamin C, E, beta-carotene, LDL oxidation rate, and LDL lag time (P < 0.0001). Post hoc assessment showed elevations in vitamin C, E, and beta-carotene concentrations at 12 and 24 wk (P < 0.05). LDL oxidation lag time at baseline (57.5 +/- 13.9 min) increased by 12 wk (63.5 +/- 19.0 min; P < 0.05) and 24 wk (63.8 +/- 16.3 min; P < 0.05). LDL oxidation rate at baseline (9.7 +/- 3.0 microM x min(-1). g(-1)) was reduced at 12 wk (7.1 +/- 2.5 microM x min(-1) x g(-1); P < 0.05) and 24 wk (6.0 +/- 2.0 microM x min(-1) x g(-1); P < 0.05). Only vitamin C was significantly correlated with LDL oxidation rate (P = 0.05, r(2) = 0.003). CONCLUSIONS: A multi-ingredient vitamin formula with antioxidant properties has measurable effects on homocysteine and LDL oxidation indices. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/12297209/Efficacy_of_a_complex_multivitamin_supplement_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899900702008080 DB - PRIME DP - Unbound Medicine ER -