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Pancreatic duct stones in chronic pancreatitis: criteria for treatment intensity and success.
Gastrointest Endosc. 2002 Oct; 56(4):501-6.GE

Abstract

BACKGROUND

The aim of the study was to evaluate interventional endoscopic management of pancreatic duct stones in patients with chronic pancreatitis by describing therapeutic methods and defining factors that predict technical success.

METHODS

Records were retrospectively analyzed for 125 patients with symptoms caused by chronic pancreatitis with pancreatic duct stones (single 43, multiple 82) treated by interventional endoscopy, including extracorporeal shockwave lithotripsy.

RESULTS

Technical success was achieved in 85% of patients (11 patients by mechanical lithotripsy, 114 by piezoelectric extracorporeal shockwave lithotripsy). There were no serious complications from lithotripsy. Univariate analysis disclosed a statistically significant association between treatment success and patient age as well as prepapillary location of stones. A greater therapeutic effort was necessary in patients with stones located in the tail of the pancreas, 2 or more stones, a stone 12 mm or more in diameter, or who have had a longer duration (>8 years) of the disease. However, with exception of the last parameter, correction for multiple testing of data removed statistical significance.

CONCLUSIONS

Extracorporeal shockwave lithotripsy enhances endoscopic measures for treatment of pancreatic duct stones when mechanical lithotripsy fails. Middle-aged patients in the early stages of chronic pancreatitis with stones in a prepapillary location proved to be the best candidates for successful treatment. Unfavorable patient-related or morphologic factors can be compensated for through more intense efforts at therapy.

Authors+Show Affiliations

Department of Medicine I, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12297764

Citation

Farnbacher, Michael J., et al. "Pancreatic Duct Stones in Chronic Pancreatitis: Criteria for Treatment Intensity and Success." Gastrointestinal Endoscopy, vol. 56, no. 4, 2002, pp. 501-6.
Farnbacher MJ, Schoen C, Rabenstein T, et al. Pancreatic duct stones in chronic pancreatitis: criteria for treatment intensity and success. Gastrointest Endosc. 2002;56(4):501-6.
Farnbacher, M. J., Schoen, C., Rabenstein, T., Benninger, J., Hahn, E. G., & Schneider, H. T. (2002). Pancreatic duct stones in chronic pancreatitis: criteria for treatment intensity and success. Gastrointestinal Endoscopy, 56(4), 501-6.
Farnbacher MJ, et al. Pancreatic Duct Stones in Chronic Pancreatitis: Criteria for Treatment Intensity and Success. Gastrointest Endosc. 2002;56(4):501-6. PubMed PMID: 12297764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic duct stones in chronic pancreatitis: criteria for treatment intensity and success. AU - Farnbacher,Michael J, AU - Schoen,Christoph, AU - Rabenstein,Thomas, AU - Benninger,Johannes, AU - Hahn,Eckhart G, AU - Schneider,H Thomas, PY - 2002/9/26/pubmed PY - 2002/12/4/medline PY - 2002/9/26/entrez SP - 501 EP - 6 JF - Gastrointestinal endoscopy JO - Gastrointest. Endosc. VL - 56 IS - 4 N2 - BACKGROUND: The aim of the study was to evaluate interventional endoscopic management of pancreatic duct stones in patients with chronic pancreatitis by describing therapeutic methods and defining factors that predict technical success. METHODS: Records were retrospectively analyzed for 125 patients with symptoms caused by chronic pancreatitis with pancreatic duct stones (single 43, multiple 82) treated by interventional endoscopy, including extracorporeal shockwave lithotripsy. RESULTS: Technical success was achieved in 85% of patients (11 patients by mechanical lithotripsy, 114 by piezoelectric extracorporeal shockwave lithotripsy). There were no serious complications from lithotripsy. Univariate analysis disclosed a statistically significant association between treatment success and patient age as well as prepapillary location of stones. A greater therapeutic effort was necessary in patients with stones located in the tail of the pancreas, 2 or more stones, a stone 12 mm or more in diameter, or who have had a longer duration (>8 years) of the disease. However, with exception of the last parameter, correction for multiple testing of data removed statistical significance. CONCLUSIONS: Extracorporeal shockwave lithotripsy enhances endoscopic measures for treatment of pancreatic duct stones when mechanical lithotripsy fails. Middle-aged patients in the early stages of chronic pancreatitis with stones in a prepapillary location proved to be the best candidates for successful treatment. Unfavorable patient-related or morphologic factors can be compensated for through more intense efforts at therapy. SN - 0016-5107 UR - https://www.unboundmedicine.com/medline/citation/12297764/Pancreatic_duct_stones_in_chronic_pancreatitis:_criteria_for_treatment_intensity_and_success_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5107(02)70433-1 DB - PRIME DP - Unbound Medicine ER -