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Frequency of the Amsterdam criteria in a regional German cohort of patients with colorectal cancer.
Z Gastroenterol. 2002 Aug; 40(8):561-8.ZG

Abstract

Estimates of the colon cancer burden associated with hereditary nonpolyposis colorectal cancer (HNPCC) vary from less than 1 % to more than 5 %. Amsterdam criteria fulfilled within a kindred (classic Amsterdam and Amsterdam II criteria) are widely used to identify patients prone to HNPCC. The present study was initiated to assess the frequency of the Amsterdam criteria within a regional German cohort of 207 patients with a history of colorectal cancer (CRC). Data on individual and family cancer histories were available in 154 patients (73 women, 81 men; mean age at diagnosis 62.4 +/- 13.3 years). A total of 843 first degree relatives have been identified within the kindreds of whom 121 had verified cancers. In 28 of 154 families (18 %), at least one first degree relative of the index patient had CRC. With respect to a typical family history, five kindreds (3.2 %) were likely to suffer from HNPCC on a clinical basis (4 kindreds met the classic Amsterdam criteria and one kindred the Amsterdam II criteria). Testing for microsatellite instability could additionally be performed in 4 of 5 patients who met the Amsterdam criteria and revealed DNA instability in 3 cases. Moreover, a missense mutation of MSH2 (Gly965Asp) was detected in one patient with microsatellite instability. Based on the classic Amsterdam and Amsterdam II criteria approximately 3 % of a regional German cohort of patients with CRC are likely to suffer from HNPCC. However, the final diagnosis of HNPCC can only be established by detection of pathogenic germline mutations within the DNA mismatch repair genes.

Authors+Show Affiliations

Medizinische Klinik II, Klinikum der J. W. Goethe-Universität, Frankfurt/Main, Germany. Raedle@em.uni-frankfurt.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12297979

Citation

Raedle, J, et al. "Frequency of the Amsterdam Criteria in a Regional German Cohort of Patients With Colorectal Cancer." Zeitschrift Fur Gastroenterologie, vol. 40, no. 8, 2002, pp. 561-8.
Raedle J, Schaffner M, Esser N, et al. Frequency of the Amsterdam criteria in a regional German cohort of patients with colorectal cancer. Z Gastroenterol. 2002;40(8):561-8.
Raedle, J., Schaffner, M., Esser, N., Sahm, S., Trojan, J., Kriener, S., Brieger, A., Nier, H., Bockhorn, H., Berg, P. L., Frick, B., Schäfer, D., & Zeuzem, S. (2002). Frequency of the Amsterdam criteria in a regional German cohort of patients with colorectal cancer. Zeitschrift Fur Gastroenterologie, 40(8), 561-8.
Raedle J, et al. Frequency of the Amsterdam Criteria in a Regional German Cohort of Patients With Colorectal Cancer. Z Gastroenterol. 2002;40(8):561-8. PubMed PMID: 12297979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency of the Amsterdam criteria in a regional German cohort of patients with colorectal cancer. AU - Raedle,J, AU - Schaffner,M, AU - Esser,N, AU - Sahm,S, AU - Trojan,J, AU - Kriener,S, AU - Brieger,A, AU - Nier,H, AU - Bockhorn,H, AU - Berg,P L, AU - Frick,B, AU - Schäfer,D, AU - Zeuzem,S, PY - 2002/9/26/pubmed PY - 2003/1/15/medline PY - 2002/9/26/entrez SP - 561 EP - 8 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 40 IS - 8 N2 - Estimates of the colon cancer burden associated with hereditary nonpolyposis colorectal cancer (HNPCC) vary from less than 1 % to more than 5 %. Amsterdam criteria fulfilled within a kindred (classic Amsterdam and Amsterdam II criteria) are widely used to identify patients prone to HNPCC. The present study was initiated to assess the frequency of the Amsterdam criteria within a regional German cohort of 207 patients with a history of colorectal cancer (CRC). Data on individual and family cancer histories were available in 154 patients (73 women, 81 men; mean age at diagnosis 62.4 +/- 13.3 years). A total of 843 first degree relatives have been identified within the kindreds of whom 121 had verified cancers. In 28 of 154 families (18 %), at least one first degree relative of the index patient had CRC. With respect to a typical family history, five kindreds (3.2 %) were likely to suffer from HNPCC on a clinical basis (4 kindreds met the classic Amsterdam criteria and one kindred the Amsterdam II criteria). Testing for microsatellite instability could additionally be performed in 4 of 5 patients who met the Amsterdam criteria and revealed DNA instability in 3 cases. Moreover, a missense mutation of MSH2 (Gly965Asp) was detected in one patient with microsatellite instability. Based on the classic Amsterdam and Amsterdam II criteria approximately 3 % of a regional German cohort of patients with CRC are likely to suffer from HNPCC. However, the final diagnosis of HNPCC can only be established by detection of pathogenic germline mutations within the DNA mismatch repair genes. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/12297979/Frequency_of_the_Amsterdam_criteria_in_a_regional_German_cohort_of_patients_with_colorectal_cancer_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-33419 DB - PRIME DP - Unbound Medicine ER -