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[Properties of C protein from skeletal and cardiac muscles of the ground squirrel Citellus undulatus at various stages of hibernation].

Abstract

Changes in the molecular weight and functional properties of the C and X proteins from skeletal muscles and the C protein from the cardiac muscle of hibernating ground squirrels Citellus undulatus at different stages of the hibernation were studied. A decrease in the molecular weight of the C protein from fast fibers of skeletal muscles of hibernating ground squirrels compared with awakening and active animals was revealed. The appearance of shorter molecules of the C protein upon hibernation was accompanied by a lowering of its capacity to enhance the actin-activated ATPase activity of control myosin and by the inhibition of its Ca(2+)-sensitivity. No similar changes were observed for the skeletal X protein and the cardiac C protein. The influence of the skeletal C protein on the main functional properties of myosin allows one to draw a conclusion about its contribution to the inhibition of contractile activity of skeletal muscles upon hibernation. The physiological significance of the changes in the C protein upon hibernation is discussed in connection with similar changes in some cardiomyopathies.

Authors+Show Affiliations

,

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia.

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Source

Biofizika 47:4 pg 701-5

MeSH

Actomyosin
Adenosine Triphosphatases
Animals
Calcium
Carrier Proteins
Electrophoresis, Polyacrylamide Gel
Hibernation
Molecular Weight
Muscle, Skeletal
Myocardium
Sciuridae

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

12298210

Citation

Vikhliantsev, I M., et al. "[Properties of C Protein From Skeletal and Cardiac Muscles of the Ground Squirrel Citellus Undulatus at Various Stages of Hibernation]." Biofizika, vol. 47, no. 4, 2002, pp. 701-5.
Vikhliantsev IM, Alekseeva IuA, Shpagina MD, et al. [Properties of C protein from skeletal and cardiac muscles of the ground squirrel Citellus undulatus at various stages of hibernation]. Biofizika. 2002;47(4):701-5.
Vikhliantsev, I. M., Alekseeva, I. u. A., Shpagina, M. D., Udal'tsov, S. N., & Podlubnaia, Z. A. (2002). [Properties of C protein from skeletal and cardiac muscles of the ground squirrel Citellus undulatus at various stages of hibernation]. Biofizika, 47(4), pp. 701-5.
Vikhliantsev IM, et al. [Properties of C Protein From Skeletal and Cardiac Muscles of the Ground Squirrel Citellus Undulatus at Various Stages of Hibernation]. Biofizika. 2002;47(4):701-5. PubMed PMID: 12298210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Properties of C protein from skeletal and cardiac muscles of the ground squirrel Citellus undulatus at various stages of hibernation]. AU - Vikhliantsev,I M, AU - Alekseeva,Iu A, AU - Shpagina,M D, AU - Udal'tsov,S N, AU - Podlubnaia,Z A, PY - 2002/9/27/pubmed PY - 2002/11/28/medline PY - 2002/9/27/entrez SP - 701 EP - 5 JF - Biofizika JO - Biofizika VL - 47 IS - 4 N2 - Changes in the molecular weight and functional properties of the C and X proteins from skeletal muscles and the C protein from the cardiac muscle of hibernating ground squirrels Citellus undulatus at different stages of the hibernation were studied. A decrease in the molecular weight of the C protein from fast fibers of skeletal muscles of hibernating ground squirrels compared with awakening and active animals was revealed. The appearance of shorter molecules of the C protein upon hibernation was accompanied by a lowering of its capacity to enhance the actin-activated ATPase activity of control myosin and by the inhibition of its Ca(2+)-sensitivity. No similar changes were observed for the skeletal X protein and the cardiac C protein. The influence of the skeletal C protein on the main functional properties of myosin allows one to draw a conclusion about its contribution to the inhibition of contractile activity of skeletal muscles upon hibernation. The physiological significance of the changes in the C protein upon hibernation is discussed in connection with similar changes in some cardiomyopathies. SN - 0006-3029 UR - https://www.unboundmedicine.com/medline/citation/12298210/[Properties_of_C_protein_from_skeletal_and_cardiac_muscles_of_the_ground_squirrel_Citellus_undulatus_at_various_stages_of_hibernation]_ DB - PRIME DP - Unbound Medicine ER -