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Adipose tissue biomarkers of fatty acid intake.
Am J Clin Nutr 2002; 76(4):750-7AJ

Abstract

BACKGROUND

Biomarkers can provide a more accurate measure of long-term intake than can dietary questionnaires.

OBJECTIVE

The objective was to identify which adipose tissue fatty acids are suitable biomarkers of intake as assessed with a validated food-frequency questionnaire.

DESIGN

Costa Rican men with a mean (+/- SD) age of 56 +/- 11 y (n = 367) and women aged 60 +/- 10 y (n = 136) completed a 135-item food-frequency questionnaire and provided an adipose tissue sample. Fifty fatty acids were identified by capillary gas chromatography. Correlation coefficients were calculated after adjustment for age, sex, body mass index, and smoking status.

RESULTS

The best adipose tissue marker for total intake of saturated fatty acids was 15:0 + 17:0 (r = 0.18). Both 15:0 and 17:0 were also the best correlates of dairy product intake (r = 0.31 for each). The diet-adipose tissue correlations for n-3 fatty acids were r = 0.34 for 18:3, r = 0.15 for 20:5, and r = 0.18 for 22:6. Fish intake correlated significantly with these adipose tissue n-3 fatty acids. Dietary and adipose tissue n-6 fatty acids were highly correlated: 18:2 (r = 0.58) and 18:3 (r = 0.24). The best indicators of total trans fatty acid intake were ct18:2n-6 and tc18:2n-6 (r = 0.58 for each); total 18:1 trans fatty acid (r = 0.45) and 16:1 trans fatty acid (r = 0.16) were the next best indicators.

CONCLUSIONS

Adipose tissue is a suitable biomarker of dietary fatty acid intake, particularly for n-3 and n-6 cis polyunsaturated fatty acids and trans fatty acids. Ideally, adipose tissue and dietary questionnaires should complement, rather than substitute for, each other in epidemiologic studies.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12324287

Citation

Baylin, Ana, et al. "Adipose Tissue Biomarkers of Fatty Acid Intake." The American Journal of Clinical Nutrition, vol. 76, no. 4, 2002, pp. 750-7.
Baylin A, Kabagambe EK, Siles X, et al. Adipose tissue biomarkers of fatty acid intake. Am J Clin Nutr. 2002;76(4):750-7.
Baylin, A., Kabagambe, E. K., Siles, X., & Campos, H. (2002). Adipose tissue biomarkers of fatty acid intake. The American Journal of Clinical Nutrition, 76(4), pp. 750-7.
Baylin A, et al. Adipose Tissue Biomarkers of Fatty Acid Intake. Am J Clin Nutr. 2002;76(4):750-7. PubMed PMID: 12324287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipose tissue biomarkers of fatty acid intake. AU - Baylin,Ana, AU - Kabagambe,Edmond K, AU - Siles,Xinia, AU - Campos,Hannia, PY - 2002/9/27/pubmed PY - 2002/10/12/medline PY - 2002/9/27/entrez SP - 750 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 76 IS - 4 N2 - BACKGROUND: Biomarkers can provide a more accurate measure of long-term intake than can dietary questionnaires. OBJECTIVE: The objective was to identify which adipose tissue fatty acids are suitable biomarkers of intake as assessed with a validated food-frequency questionnaire. DESIGN: Costa Rican men with a mean (+/- SD) age of 56 +/- 11 y (n = 367) and women aged 60 +/- 10 y (n = 136) completed a 135-item food-frequency questionnaire and provided an adipose tissue sample. Fifty fatty acids were identified by capillary gas chromatography. Correlation coefficients were calculated after adjustment for age, sex, body mass index, and smoking status. RESULTS: The best adipose tissue marker for total intake of saturated fatty acids was 15:0 + 17:0 (r = 0.18). Both 15:0 and 17:0 were also the best correlates of dairy product intake (r = 0.31 for each). The diet-adipose tissue correlations for n-3 fatty acids were r = 0.34 for 18:3, r = 0.15 for 20:5, and r = 0.18 for 22:6. Fish intake correlated significantly with these adipose tissue n-3 fatty acids. Dietary and adipose tissue n-6 fatty acids were highly correlated: 18:2 (r = 0.58) and 18:3 (r = 0.24). The best indicators of total trans fatty acid intake were ct18:2n-6 and tc18:2n-6 (r = 0.58 for each); total 18:1 trans fatty acid (r = 0.45) and 16:1 trans fatty acid (r = 0.16) were the next best indicators. CONCLUSIONS: Adipose tissue is a suitable biomarker of dietary fatty acid intake, particularly for n-3 and n-6 cis polyunsaturated fatty acids and trans fatty acids. Ideally, adipose tissue and dietary questionnaires should complement, rather than substitute for, each other in epidemiologic studies. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12324287/Adipose_tissue_biomarkers_of_fatty_acid_intake_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/76.4.750 DB - PRIME DP - Unbound Medicine ER -