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Dietary carotenoids and risk of breast cancer.
Am J Clin Nutr. 2002 Oct; 76(4):883-8.AJ

Abstract

BACKGROUND

Many studies of fruit and vegetable consumption showed inverse associations with breast cancer risk, suggesting the potential importance of carotenoids (and other phytochemicals) contained in these foods. To date, however, only one prospective cohort study has examined dietary carotenoids other than beta-carotene in relation to breast cancer risk.

OBJECTIVE

Our aim was to examine the relations between dietary intakes of beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, and lutein + zeaxanthin and breast cancer risk in a large cohort study of Canadian women.

DESIGN

A case-cohort analysis was undertaken in a cohort of 56 837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993 a total of 1589 women were diagnosed with biopsy-confirmed incident breast cancer. For comparison, a subcohort of 5681 women was randomly selected. After exclusions for various reasons, the analyses were based on 1452 cases and 5239 noncases.

RESULTS

We found no clear association between intakes of any of the studied carotenoids and breast cancer risk in the study population as a whole or in subgroups defined by smoking status; relative body weight (assessed by body mass index); intakes of total fat, energy, alcohol, or folic acid; family history of breast cancer; or menopausal status.

CONCLUSIONS

Our data do not support any association between dietary intakes of the studied carotenoids and breast cancer risk. However, prospective cohort studies of carotenoids in relation to breast cancer are scarce and further studies are warranted.

Authors+Show Affiliations

Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. pterry@aecom.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12324304

Citation

Terry, Paul, et al. "Dietary Carotenoids and Risk of Breast Cancer." The American Journal of Clinical Nutrition, vol. 76, no. 4, 2002, pp. 883-8.
Terry P, Jain M, Miller AB, et al. Dietary carotenoids and risk of breast cancer. Am J Clin Nutr. 2002;76(4):883-8.
Terry, P., Jain, M., Miller, A. B., Howe, G. R., & Rohan, T. E. (2002). Dietary carotenoids and risk of breast cancer. The American Journal of Clinical Nutrition, 76(4), 883-8.
Terry P, et al. Dietary Carotenoids and Risk of Breast Cancer. Am J Clin Nutr. 2002;76(4):883-8. PubMed PMID: 12324304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary carotenoids and risk of breast cancer. AU - Terry,Paul, AU - Jain,Meera, AU - Miller,Anthony B, AU - Howe,Geoffrey R, AU - Rohan,Thomas E, PY - 2002/9/27/pubmed PY - 2002/10/12/medline PY - 2002/9/27/entrez SP - 883 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 76 IS - 4 N2 - BACKGROUND: Many studies of fruit and vegetable consumption showed inverse associations with breast cancer risk, suggesting the potential importance of carotenoids (and other phytochemicals) contained in these foods. To date, however, only one prospective cohort study has examined dietary carotenoids other than beta-carotene in relation to breast cancer risk. OBJECTIVE: Our aim was to examine the relations between dietary intakes of beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, and lutein + zeaxanthin and breast cancer risk in a large cohort study of Canadian women. DESIGN: A case-cohort analysis was undertaken in a cohort of 56 837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993 a total of 1589 women were diagnosed with biopsy-confirmed incident breast cancer. For comparison, a subcohort of 5681 women was randomly selected. After exclusions for various reasons, the analyses were based on 1452 cases and 5239 noncases. RESULTS: We found no clear association between intakes of any of the studied carotenoids and breast cancer risk in the study population as a whole or in subgroups defined by smoking status; relative body weight (assessed by body mass index); intakes of total fat, energy, alcohol, or folic acid; family history of breast cancer; or menopausal status. CONCLUSIONS: Our data do not support any association between dietary intakes of the studied carotenoids and breast cancer risk. However, prospective cohort studies of carotenoids in relation to breast cancer are scarce and further studies are warranted. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12324304/Dietary_carotenoids_and_risk_of_breast_cancer_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/76.4.883 DB - PRIME DP - Unbound Medicine ER -