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Effect of fish oil versus corn oil supplementation on LDL and HDL subclasses in type 2 diabetic patients.
Diabetes Care. 2002 Oct; 25(10):1704-8.DC

Abstract

OBJECTIVE

The increased risk of coronary heart disease associated with type 2 diabetes may be partially explained by dyslipidemia characterized by high plasma triacylglycerol (TAG), low HDL cholesterol, and a predominance of atherogenic small dense LDLs. Fish oil reduces plasma TAG and has previously been shown to improve the distribution of LDL subclasses in healthy subjects and might, therefore, be a good nonpharmacological treatment for type 2 diabetic patients. In the present study, we investigate the effect of fish oil supplementation on the fasting lipid profile, including LDL and HDL subclasses.

RESEARCH DESIGN AND METHODS

A total of 42 type 2 diabetic patients were randomized to supplementation (capsules) with 4 g daily of either fish oil (n = 20) or corn oil (n = 22) for 8 weeks preceded by a 4-week run-in period of corn oil supplementation. Blood was drawn before and after the 8-week intervention period. Plasma lipoproteins, including LDL and HDL subclasses, were separated by ultracentrifugation.

RESULTS

Fish oil lowered TAG (group difference: P = 0.025) and raised HDL-2b cholesterol (P = 0.012) and HDL-2a cholesterol (P = 0.007) concentrations as compared with corn oil. We observed no significant effects of fish oil on LDL cholesterol, HDL cholesterol, or the concentration of small dense LDL particles.

CONCLUSIONS

Fish oil supplementation may partially correct the dyslipidemia of type 2 diabetic patients. However, the putative very important aspect of diabetic dyslipidemia-the predominance of small dense LDL particles-was unaffected by fish oil.

Authors+Show Affiliations

Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. mpe@kvl.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12351465

Citation

Petersen, Martin, et al. "Effect of Fish Oil Versus Corn Oil Supplementation On LDL and HDL Subclasses in Type 2 Diabetic Patients." Diabetes Care, vol. 25, no. 10, 2002, pp. 1704-8.
Petersen M, Pedersen H, Major-Pedersen A, et al. Effect of fish oil versus corn oil supplementation on LDL and HDL subclasses in type 2 diabetic patients. Diabetes Care. 2002;25(10):1704-8.
Petersen, M., Pedersen, H., Major-Pedersen, A., Jensen, T., & Marckmann, P. (2002). Effect of fish oil versus corn oil supplementation on LDL and HDL subclasses in type 2 diabetic patients. Diabetes Care, 25(10), 1704-8.
Petersen M, et al. Effect of Fish Oil Versus Corn Oil Supplementation On LDL and HDL Subclasses in Type 2 Diabetic Patients. Diabetes Care. 2002;25(10):1704-8. PubMed PMID: 12351465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fish oil versus corn oil supplementation on LDL and HDL subclasses in type 2 diabetic patients. AU - Petersen,Martin, AU - Pedersen,Helle, AU - Major-Pedersen,Atheline, AU - Jensen,Tonny, AU - Marckmann,Peter, PY - 2002/9/28/pubmed PY - 2003/4/1/medline PY - 2002/9/28/entrez SP - 1704 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 25 IS - 10 N2 - OBJECTIVE: The increased risk of coronary heart disease associated with type 2 diabetes may be partially explained by dyslipidemia characterized by high plasma triacylglycerol (TAG), low HDL cholesterol, and a predominance of atherogenic small dense LDLs. Fish oil reduces plasma TAG and has previously been shown to improve the distribution of LDL subclasses in healthy subjects and might, therefore, be a good nonpharmacological treatment for type 2 diabetic patients. In the present study, we investigate the effect of fish oil supplementation on the fasting lipid profile, including LDL and HDL subclasses. RESEARCH DESIGN AND METHODS: A total of 42 type 2 diabetic patients were randomized to supplementation (capsules) with 4 g daily of either fish oil (n = 20) or corn oil (n = 22) for 8 weeks preceded by a 4-week run-in period of corn oil supplementation. Blood was drawn before and after the 8-week intervention period. Plasma lipoproteins, including LDL and HDL subclasses, were separated by ultracentrifugation. RESULTS: Fish oil lowered TAG (group difference: P = 0.025) and raised HDL-2b cholesterol (P = 0.012) and HDL-2a cholesterol (P = 0.007) concentrations as compared with corn oil. We observed no significant effects of fish oil on LDL cholesterol, HDL cholesterol, or the concentration of small dense LDL particles. CONCLUSIONS: Fish oil supplementation may partially correct the dyslipidemia of type 2 diabetic patients. However, the putative very important aspect of diabetic dyslipidemia-the predominance of small dense LDL particles-was unaffected by fish oil. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/12351465/Effect_of_fish_oil_versus_corn_oil_supplementation_on_LDL_and_HDL_subclasses_in_type_2_diabetic_patients_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=12351465 DB - PRIME DP - Unbound Medicine ER -