Pernicious anaemia: its pathogenesis in the light of the beneficial effect of duodenal intrinsic factor.
Acta Med Acad Sci Hung. 1975; 32(2):123-7.AM

Abstract

Oral ingestion of powdered duodenal mucosa with small doses of vitamin B12 proved efficient in four cases of untreated pernicious anaemia. The erythropoietic as well as the other responses were similar as those elicited by any reliable anti-pernicious drug. It has thus been confirmed that the growth factor demonstrated earlier in human duodenal juice by means of E. coli mutant corresponds in fact to the intrinsic factor. It is suggested that besides the deficiency of gastric intrinsic factor the duodenal intrinsic factor and the immune mechanisms neutralizing it are also involved in the pathogenesis. It has been shown that the aqueous extracts of hog stomach and duodenum differ in addition to their growth factor and nitrogen contents, also in aminoacid composition.

Authors

Horányi M

No affiliation info available

Sárfy H

No affiliation info available

MeSH

Anemia, PerniciousDuodenumErythrocyte CountHumansIntrinsic FactorReticulocytes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1235219

Citation

Horányi, M, and H Sárfy. "Pernicious Anaemia: Its Pathogenesis in the Light of the Beneficial Effect of Duodenal Intrinsic Factor." Acta Medica Academiae Scientiarum Hungaricae, vol. 32, no. 2, 1975, pp. 123-7.

Horányi M, Sárfy H. Pernicious anaemia: its pathogenesis in the light of the beneficial effect of duodenal intrinsic factor. Acta Med Acad Sci Hung. 1975;32(2):123-7.

Horányi, M., & Sárfy, H. (1975). Pernicious anaemia: its pathogenesis in the light of the beneficial effect of duodenal intrinsic factor. Acta Medica Academiae Scientiarum Hungaricae, 32(2), 123-7.

Horányi M, Sárfy H. Pernicious Anaemia: Its Pathogenesis in the Light of the Beneficial Effect of Duodenal Intrinsic Factor. Acta Med Acad Sci Hung. 1975;32(2):123-7. PubMed PMID: 1235219.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Pernicious anaemia: its pathogenesis in the light of the beneficial effect of duodenal intrinsic factor. AU - Horányi,M, AU - Sárfy,H, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 123 EP - 7 JF - Acta medica Academiae Scientiarum Hungaricae JO - Acta Med Acad Sci Hung VL - 32 IS - 2 N2 - Oral ingestion of powdered duodenal mucosa with small doses of vitamin B12 proved efficient in four cases of untreated pernicious anaemia. The erythropoietic as well as the other responses were similar as those elicited by any reliable anti-pernicious drug. It has thus been confirmed that the growth factor demonstrated earlier in human duodenal juice by means of E. coli mutant corresponds in fact to the intrinsic factor. It is suggested that besides the deficiency of gastric intrinsic factor the duodenal intrinsic factor and the immune mechanisms neutralizing it are also involved in the pathogenesis. It has been shown that the aqueous extracts of hog stomach and duodenum differ in addition to their growth factor and nitrogen contents, also in aminoacid composition. SN - 0001-5989 UR - https://www.unboundmedicine.com/medline/citation/1235219/Pernicious_anaemia:_its_pathogenesis_in_the_light_of_the_beneficial_effect_of_duodenal_intrinsic_factor_ DB - PRIME DP - Unbound Medicine ER -

Tags

Pernicious anaemia: its pathogenesis in the light of the beneficial effect of duodenal intrinsic factor.Acta Med Acad Sci Hung. 1975; 32(2):123-7.AM