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The lack of influence of CagA positive Helicobacter pylori strains on gastro-oesophageal reflux disease.
Eur J Gastroenterol Hepatol. 2002 Sep; 14(9):979-84.EJ

Abstract

OBJECTIVE

Helicobacter pylori infection of the gastric mucosa may influence gastro-oesophageal reflux disease (GORD). The protein of cytotoxin associated gene A (CagA) is assumed to be a virulence factor of H. pylori. CagA positive strains may induce severe gastroduodenal peptic ulcer disease. The aim of this study was to evaluate the association between H. pylori strains expressing CagA and GORD.

SUBJECTS AND METHODS

Nine hundred and thirty patients were examined by endoscopy. Antral and corpus biopsies for the urease test and serum samples for the detection of IgG antibodies to CagA were taken. Serum samples were assayed by using the western blot technique.

RESULTS

The results from 811 patients were analysed statistically. This study population consisted of 264 H. pylori infected patients (264/811, 32%). The H. pylori prevalence was 33% (89/266) in patients with reflux oesophagitis and did not differ from those patients without oesophagitis (175/545, 32%). In contrast, patients with Barrett's oesophagus showed a significantly lower prevalence of H. pylori infection than the other three groups (8/35, 23%). There was no significant influence of CagA, as one of the H. pylori virulence factors, on GORD. Antibodies against CagA were slightly, but insignificantly, more frequent in patients with oesophagitis (55/89, 62%) than in patients without oesophagitis (94/175, 54%).

CONCLUSIONS

In a large cohort of GORD patients no significant difference in the prevalence of H. pylori in patients with and without GORD was found. In addition, there is no correlation between patients carrying CagA positive strains and development of reflux oesophagitis. However, in the case of histopathologically proven Barrett's oesophagus the prevalence of H. pylori was significantly lower. The influence of CagA positive strains on oesophageal mucosa is discussed.

Authors+Show Affiliations

Department of Medicine I, St Josef Hospital, Ruhr University of Bochum Medical School, Gudsrunstrasse 56, D-44791 Bochum, Germany. uta.kiltz@ruhr-uni-bochum.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12352217

Citation

Kiltz, Uta, et al. "The Lack of Influence of CagA Positive Helicobacter Pylori Strains On Gastro-oesophageal Reflux Disease." European Journal of Gastroenterology & Hepatology, vol. 14, no. 9, 2002, pp. 979-84.
Kiltz U, Pfaffenbach B, Schmidt WE, et al. The lack of influence of CagA positive Helicobacter pylori strains on gastro-oesophageal reflux disease. Eur J Gastroenterol Hepatol. 2002;14(9):979-84.
Kiltz, U., Pfaffenbach, B., Schmidt, W. E., & Adamek, R. J. (2002). The lack of influence of CagA positive Helicobacter pylori strains on gastro-oesophageal reflux disease. European Journal of Gastroenterology & Hepatology, 14(9), 979-84.
Kiltz U, et al. The Lack of Influence of CagA Positive Helicobacter Pylori Strains On Gastro-oesophageal Reflux Disease. Eur J Gastroenterol Hepatol. 2002;14(9):979-84. PubMed PMID: 12352217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The lack of influence of CagA positive Helicobacter pylori strains on gastro-oesophageal reflux disease. AU - Kiltz,Uta, AU - Pfaffenbach,Boris, AU - Schmidt,Wolfgang E, AU - Adamek,Romuald J, PY - 2002/9/28/pubmed PY - 2002/11/26/medline PY - 2002/9/28/entrez SP - 979 EP - 84 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 14 IS - 9 N2 - OBJECTIVE: Helicobacter pylori infection of the gastric mucosa may influence gastro-oesophageal reflux disease (GORD). The protein of cytotoxin associated gene A (CagA) is assumed to be a virulence factor of H. pylori. CagA positive strains may induce severe gastroduodenal peptic ulcer disease. The aim of this study was to evaluate the association between H. pylori strains expressing CagA and GORD. SUBJECTS AND METHODS: Nine hundred and thirty patients were examined by endoscopy. Antral and corpus biopsies for the urease test and serum samples for the detection of IgG antibodies to CagA were taken. Serum samples were assayed by using the western blot technique. RESULTS: The results from 811 patients were analysed statistically. This study population consisted of 264 H. pylori infected patients (264/811, 32%). The H. pylori prevalence was 33% (89/266) in patients with reflux oesophagitis and did not differ from those patients without oesophagitis (175/545, 32%). In contrast, patients with Barrett's oesophagus showed a significantly lower prevalence of H. pylori infection than the other three groups (8/35, 23%). There was no significant influence of CagA, as one of the H. pylori virulence factors, on GORD. Antibodies against CagA were slightly, but insignificantly, more frequent in patients with oesophagitis (55/89, 62%) than in patients without oesophagitis (94/175, 54%). CONCLUSIONS: In a large cohort of GORD patients no significant difference in the prevalence of H. pylori in patients with and without GORD was found. In addition, there is no correlation between patients carrying CagA positive strains and development of reflux oesophagitis. However, in the case of histopathologically proven Barrett's oesophagus the prevalence of H. pylori was significantly lower. The influence of CagA positive strains on oesophageal mucosa is discussed. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/12352217/The_lack_of_influence_of_CagA_positive_Helicobacter_pylori_strains_on_gastro_oesophageal_reflux_disease_ L2 - https://doi.org/10.1097/00042737-200209000-00008 DB - PRIME DP - Unbound Medicine ER -