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Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population.
J Infect Dis 2002; 186(8):1138-44JI

Abstract

Helicobacter pylori colonization is associated with gastric cancer, but whether and to what extent the risk is greater for strains with the cagA gene than for those without needs to be determined. Between 1967 and 1977, 9963 Japanese American men were recruited and examined. By 1996, incident cases of gastric carcinoma of the distal stomach had been diagnosed in 261 men. Stored serum samples from these case patients and 261 age-matched control subjects were tested for immunoglobulin G antibodies to H. pylori and to the CagA product of H. pylori, using antibody-specific enzyme-linked immunosorbent assays. Compared with H. pylori-negative, CagA-negative men, H. pylori-positive, CagA-negative men had an odds ratio (OR) of 2.7 (95% confidence interval [CI], 1.3-5.6) for intestinal gastric carcinoma. Men seropositive for both H. pylori and CagA had an OR of 4.1 (95% CI, 2.2-7.7). This suggests that colonization by an H. pylori strain with the cagA gene is associated with a greater risk of intestinal gastric carcinoma.

Authors+Show Affiliations

Japan-Hawaii Cancer Study, Kuakini Medical Center, 347 N. Kuakini Street, Honolulu, HI 96817, USA. abe@kuakini.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12355365

Citation

Nomura, Abraham M Y., et al. "Helicobacter Pylori CagA Seropositivity and Gastric Carcinoma Risk in a Japanese American Population." The Journal of Infectious Diseases, vol. 186, no. 8, 2002, pp. 1138-44.
Nomura AM, Lee J, Stemmermann GN, et al. Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population. J Infect Dis. 2002;186(8):1138-44.
Nomura, A. M., Lee, J., Stemmermann, G. N., Nomura, R. Y., Perez-Perez, G. I., & Blaser, M. J. (2002). Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population. The Journal of Infectious Diseases, 186(8), pp. 1138-44.
Nomura AM, et al. Helicobacter Pylori CagA Seropositivity and Gastric Carcinoma Risk in a Japanese American Population. J Infect Dis. 2002 Oct 15;186(8):1138-44. PubMed PMID: 12355365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population. AU - Nomura,Abraham M Y, AU - Lee,James, AU - Stemmermann,Grant N, AU - Nomura,Ryan Y, AU - Perez-Perez,Guillermo I, AU - Blaser,Martin J, Y1 - 2002/09/25/ PY - 2002/02/19/received PY - 2002/06/10/revised PY - 2002/10/2/pubmed PY - 2002/11/26/medline PY - 2002/10/2/entrez SP - 1138 EP - 44 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 186 IS - 8 N2 - Helicobacter pylori colonization is associated with gastric cancer, but whether and to what extent the risk is greater for strains with the cagA gene than for those without needs to be determined. Between 1967 and 1977, 9963 Japanese American men were recruited and examined. By 1996, incident cases of gastric carcinoma of the distal stomach had been diagnosed in 261 men. Stored serum samples from these case patients and 261 age-matched control subjects were tested for immunoglobulin G antibodies to H. pylori and to the CagA product of H. pylori, using antibody-specific enzyme-linked immunosorbent assays. Compared with H. pylori-negative, CagA-negative men, H. pylori-positive, CagA-negative men had an odds ratio (OR) of 2.7 (95% confidence interval [CI], 1.3-5.6) for intestinal gastric carcinoma. Men seropositive for both H. pylori and CagA had an OR of 4.1 (95% CI, 2.2-7.7). This suggests that colonization by an H. pylori strain with the cagA gene is associated with a greater risk of intestinal gastric carcinoma. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12355365/Helicobacter_pylori_CagA_seropositivity_and_gastric_carcinoma_risk_in_a_Japanese_American_population_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/343808 DB - PRIME DP - Unbound Medicine ER -