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High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.
J Infect Dis. 2002 Oct 15; 186(8):1165-8.JI

Abstract

Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease. The morbidity and mortality of DHF can be reduced by early hospitalization and careful supportive care. To determine its usefulness as a predictor of DHF, plasma levels of the secreted dengue virus nonstructural protein NS1 (sNS1) were measured daily in 32 children with dengue-2 virus infections participating in a prospective, hospital-based study. Free sNS1 levels in plasma correlated with viremia levels and were higher in patients with DHF than in those with DF. An elevated free sNS1 level (> or =600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF.

Authors+Show Affiliations

Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USA. daniel.libraty@umassmed.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12355369

Citation

Libraty, Daniel H., et al. "High Circulating Levels of the Dengue Virus Nonstructural Protein NS1 Early in Dengue Illness Correlate With the Development of Dengue Hemorrhagic Fever." The Journal of Infectious Diseases, vol. 186, no. 8, 2002, pp. 1165-8.
Libraty DH, Young PR, Pickering D, et al. High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. J Infect Dis. 2002;186(8):1165-8.
Libraty, D. H., Young, P. R., Pickering, D., Endy, T. P., Kalayanarooj, S., Green, S., Vaughn, D. W., Nisalak, A., Ennis, F. A., & Rothman, A. L. (2002). High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. The Journal of Infectious Diseases, 186(8), 1165-8.
Libraty DH, et al. High Circulating Levels of the Dengue Virus Nonstructural Protein NS1 Early in Dengue Illness Correlate With the Development of Dengue Hemorrhagic Fever. J Infect Dis. 2002 Oct 15;186(8):1165-8. PubMed PMID: 12355369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. AU - Libraty,Daniel H, AU - Young,Paul R, AU - Pickering,Darren, AU - Endy,Timothy P, AU - Kalayanarooj,Siripen, AU - Green,Sharone, AU - Vaughn,David W, AU - Nisalak,Ananda, AU - Ennis,Francis A, AU - Rothman,Alan L, Y1 - 2002/09/16/ PY - 2002/03/20/received PY - 2002/06/15/revised PY - 2002/10/2/pubmed PY - 2002/11/26/medline PY - 2002/10/2/entrez SP - 1165 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 186 IS - 8 N2 - Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease. The morbidity and mortality of DHF can be reduced by early hospitalization and careful supportive care. To determine its usefulness as a predictor of DHF, plasma levels of the secreted dengue virus nonstructural protein NS1 (sNS1) were measured daily in 32 children with dengue-2 virus infections participating in a prospective, hospital-based study. Free sNS1 levels in plasma correlated with viremia levels and were higher in patients with DHF than in those with DF. An elevated free sNS1 level (> or =600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12355369/High_circulating_levels_of_the_dengue_virus_nonstructural_protein_NS1_early_in_dengue_illness_correlate_with_the_development_of_dengue_hemorrhagic_fever_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/343813 DB - PRIME DP - Unbound Medicine ER -