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A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population.
J Infect Dis. 2002 Oct 15; 186(8):1190-3.JI

Abstract

A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.

Authors+Show Affiliations

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. ktosh@well.ox.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12355375

Citation

Tosh, Kerrie, et al. "A Region of Chromosome 20 Is Linked to Leprosy Susceptibility in a South Indian Population." The Journal of Infectious Diseases, vol. 186, no. 8, 2002, pp. 1190-3.
Tosh K, Meisner S, Siddiqui MR, et al. A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. J Infect Dis. 2002;186(8):1190-3.
Tosh, K., Meisner, S., Siddiqui, M. R., Balakrishnan, K., Ghei, S., Golding, M., Sengupta, U., Pitchappan, R. M., & Hill, A. V. (2002). A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. The Journal of Infectious Diseases, 186(8), 1190-3.
Tosh K, et al. A Region of Chromosome 20 Is Linked to Leprosy Susceptibility in a South Indian Population. J Infect Dis. 2002 Oct 15;186(8):1190-3. PubMed PMID: 12355375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. AU - Tosh,Kerrie, AU - Meisner,Sarah, AU - Siddiqui,M Ruby, AU - Balakrishnan,Karuppiah, AU - Ghei,Satish, AU - Golding,Marina, AU - Sengupta,Utpal, AU - Pitchappan,Ramasamy M, AU - Hill,Adrian V S, Y1 - 2002/09/30/ PY - 2002/04/24/received PY - 2002/07/01/revised PY - 2002/10/2/pubmed PY - 2002/11/26/medline PY - 2002/10/2/entrez SP - 1190 EP - 3 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 186 IS - 8 N2 - A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12355375/A_region_of_chromosome_20_is_linked_to_leprosy_susceptibility_in_a_South_Indian_population_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/343806 DB - PRIME DP - Unbound Medicine ER -