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Protective effects of quercetin on ultraviolet A light-induced oxidative stress in the blood of rat.
J Appl Toxicol. 2002 Sep-Oct; 22(5):303-9.JA

Abstract

The oxidative effects of ultraviolet A (UVA) light (320-400 nm) and the antioxidant effects of quercetin were examined in rat blood. For this purpose, rats were divided into three groups: control, ultraviolet (UV) and ultraviolet + quercetin (UV + Q). The UV and UV + Q groups were irradiated for 4 h a day with UVA light (1.25 mW cm(2)) during periods of 3, 6 and 9 days. Quercetin (50 mg kg(-1) body wt.) was administered intraperitoneally in the UV + Q group rats before irradiation periods. Blood was taken 3, 6 and 9 days post-treatment. Plasma malondialdehyde (MDA) levels significantly increased after 9 days of daily exposure to UVA. Whole blood glutathione (GSH) levels significantly declined after 3-9 days of irradiation. Glutathione peroxidase activity on days 6 and 9 and glutathione reductase activities on days 3, 6 and 9 post-irradiation were diminished significantly. Superoxide dismutase and catalase activities decreased significantly 3-9 days post-irradiation. The administration of quercetin before the 9-day period of irradiation significantly reduced the increase in plasma MDA value. Whole blood GSH levels significantly decreased with the administration of quercetin on all days. Quercetin significantly increased antioxidant enzymes diminished by UVA irradiation. Exposure of rats to UVA light leads to oxidative stress, reflected by increased MDA and reduced antioxidant enzyme levels. The administration of quercetin appears to be a useful approach to reduce the damage produced by UVA radiation.

Authors+Show Affiliations

Department of Biochemistry, The Medical School, Afyon Kocatepe University, Afyon-03200, Turkey. ahmetkah@aku.edu.trNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12355559

Citation

Kahraman, Ahmet, and Mine Erden Inal. "Protective Effects of Quercetin On Ultraviolet a Light-induced Oxidative Stress in the Blood of Rat." Journal of Applied Toxicology : JAT, vol. 22, no. 5, 2002, pp. 303-9.
Kahraman A, Inal ME. Protective effects of quercetin on ultraviolet A light-induced oxidative stress in the blood of rat. J Appl Toxicol. 2002;22(5):303-9.
Kahraman, A., & Inal, M. E. (2002). Protective effects of quercetin on ultraviolet A light-induced oxidative stress in the blood of rat. Journal of Applied Toxicology : JAT, 22(5), 303-9.
Kahraman A, Inal ME. Protective Effects of Quercetin On Ultraviolet a Light-induced Oxidative Stress in the Blood of Rat. J Appl Toxicol. 2002 Sep-Oct;22(5):303-9. PubMed PMID: 12355559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of quercetin on ultraviolet A light-induced oxidative stress in the blood of rat. AU - Kahraman,Ahmet, AU - Inal,Mine Erden, PY - 2002/10/2/pubmed PY - 2003/2/25/medline PY - 2002/10/2/entrez SP - 303 EP - 9 JF - Journal of applied toxicology : JAT JO - J Appl Toxicol VL - 22 IS - 5 N2 - The oxidative effects of ultraviolet A (UVA) light (320-400 nm) and the antioxidant effects of quercetin were examined in rat blood. For this purpose, rats were divided into three groups: control, ultraviolet (UV) and ultraviolet + quercetin (UV + Q). The UV and UV + Q groups were irradiated for 4 h a day with UVA light (1.25 mW cm(2)) during periods of 3, 6 and 9 days. Quercetin (50 mg kg(-1) body wt.) was administered intraperitoneally in the UV + Q group rats before irradiation periods. Blood was taken 3, 6 and 9 days post-treatment. Plasma malondialdehyde (MDA) levels significantly increased after 9 days of daily exposure to UVA. Whole blood glutathione (GSH) levels significantly declined after 3-9 days of irradiation. Glutathione peroxidase activity on days 6 and 9 and glutathione reductase activities on days 3, 6 and 9 post-irradiation were diminished significantly. Superoxide dismutase and catalase activities decreased significantly 3-9 days post-irradiation. The administration of quercetin before the 9-day period of irradiation significantly reduced the increase in plasma MDA value. Whole blood GSH levels significantly decreased with the administration of quercetin on all days. Quercetin significantly increased antioxidant enzymes diminished by UVA irradiation. Exposure of rats to UVA light leads to oxidative stress, reflected by increased MDA and reduced antioxidant enzyme levels. The administration of quercetin appears to be a useful approach to reduce the damage produced by UVA radiation. SN - 0260-437X UR - https://www.unboundmedicine.com/medline/citation/12355559/Protective_effects_of_quercetin_on_ultraviolet_A_light_induced_oxidative_stress_in_the_blood_of_rat_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0260-437X&date=2002&volume=22&issue=5&spage=303 DB - PRIME DP - Unbound Medicine ER -