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The ionized fraction of serum total magnesium in hemodialysis patients: is it really lower than in healthy subjects?

Abstract

AIM OF THE STUDY

Based on data in the literature, it remains unclear whether the ionized fraction of serum total magnesium (Mg) is lower in chronic hemodialysis (HD) patients compared to healthy subjects.

PATIENTS AND METHODS

The ionized fraction of serum total Mg was investigated in 49 HD patients, pre- and post-dialysis, and compared to 30 healthy controls. The quality of the analytical performance of the Mg measurements has been emphasized by applying a reference method and/or rigorous internal quality control (IQC). In addition, the ionized fraction of serum total calcium (Ca) was measured in both populations, because the results for Mg should be related to those of Ca.

RESULTS

In HD patients, the ionized fraction of serum total Mg was on average 65% (pre-dialysis 64.2% and post-dialysis 66.2%). In healthy controls, the ionized fraction was 64.9%. When the analytical variability was taken into account, no significant differences (p > 0.05) were observed between pre- and post-dialysis samples and controls. For Ca, an ionized fraction of 55.3% was found in HD patients, which was not significantly different from the fraction obtained in the control group (55.7%).

CONCLUSION

The present study demonstrates that, compared to healthy controls, the ionized fraction of serum total Mg is not different in hemodialysis patients.

Authors+Show Affiliations

,

Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium.

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Source

Clinical nephrology 58:3 2002 Sep pg 205-10

MeSH

Aged
Calcium
Female
Humans
Kidney Failure, Chronic
Magnesium
Male
Middle Aged
Reference Values
Renal Dialysis

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12356189

Citation

Dewitte, K, et al. "The Ionized Fraction of Serum Total Magnesium in Hemodialysis Patients: Is It Really Lower Than in Healthy Subjects?" Clinical Nephrology, vol. 58, no. 3, 2002, pp. 205-10.
Dewitte K, Dhondt A, Lameire N, et al. The ionized fraction of serum total magnesium in hemodialysis patients: is it really lower than in healthy subjects? Clin Nephrol. 2002;58(3):205-10.
Dewitte, K., Dhondt, A., Lameire, N., Stöckl, D., & Thienpont, L. M. (2002). The ionized fraction of serum total magnesium in hemodialysis patients: is it really lower than in healthy subjects? Clinical Nephrology, 58(3), pp. 205-10.
Dewitte K, et al. The Ionized Fraction of Serum Total Magnesium in Hemodialysis Patients: Is It Really Lower Than in Healthy Subjects. Clin Nephrol. 2002;58(3):205-10. PubMed PMID: 12356189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ionized fraction of serum total magnesium in hemodialysis patients: is it really lower than in healthy subjects? AU - Dewitte,K, AU - Dhondt,A, AU - Lameire,N, AU - Stöckl,D, AU - Thienpont,L M, PY - 2002/10/3/pubmed PY - 2003/3/29/medline PY - 2002/10/3/entrez SP - 205 EP - 10 JF - Clinical nephrology JO - Clin. Nephrol. VL - 58 IS - 3 N2 - AIM OF THE STUDY: Based on data in the literature, it remains unclear whether the ionized fraction of serum total magnesium (Mg) is lower in chronic hemodialysis (HD) patients compared to healthy subjects. PATIENTS AND METHODS: The ionized fraction of serum total Mg was investigated in 49 HD patients, pre- and post-dialysis, and compared to 30 healthy controls. The quality of the analytical performance of the Mg measurements has been emphasized by applying a reference method and/or rigorous internal quality control (IQC). In addition, the ionized fraction of serum total calcium (Ca) was measured in both populations, because the results for Mg should be related to those of Ca. RESULTS: In HD patients, the ionized fraction of serum total Mg was on average 65% (pre-dialysis 64.2% and post-dialysis 66.2%). In healthy controls, the ionized fraction was 64.9%. When the analytical variability was taken into account, no significant differences (p > 0.05) were observed between pre- and post-dialysis samples and controls. For Ca, an ionized fraction of 55.3% was found in HD patients, which was not significantly different from the fraction obtained in the control group (55.7%). CONCLUSION: The present study demonstrates that, compared to healthy controls, the ionized fraction of serum total Mg is not different in hemodialysis patients. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/12356189/The_ionized_fraction_of_serum_total_magnesium_in_hemodialysis_patients:_is_it_really_lower_than_in_healthy_subjects L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -