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Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year.
J Am Coll Nutr 2002; 21(5):388-93JA

Abstract

BACKGROUND

The effects of isoflavone-enriched soy protein on human bone mineral content (mass) and density in healthy, menstruating young adult females have not been examined in a comparative prospective investigation. Peri- and post-menopausal women have been reported to show beneficial effects of isoflavones on bone measurements. Therefore, young women may also be able to improve their accrual of peak bone mineral content (BMC) and bone mineral density (BMD) during the early adult years of bone consolidation with an isoflavone-enriched diet.

OBJECTIVES

In this controlled, double-blind intervention, we tested the hypothesis that an isoflavone-rich soy protein diet increases BMC and BMD in young adult females over a period of one year in comparison to a control group receiving soy protein that has isoflavones removed.

DESIGN

Young healthy women of any ethnic background, 21 to 25 years of age, were divided into two groups, placebo (n = 13) and supplement (n = 15). The soy protein supplement was enriched with isoflavones (approximately 90 mg of total isoflavones/day), whereas the control protein diet was isoflavone-deficient, even though it contained the same amount of soy protein and other ingredients as the isoflavone-rich diet. Dual-energy x-ray absorptiometric (DXA) measurements of BMC and BMD were made at baseline and at 6 and 12 months. DXA estimates of body composition, including fat mass and lean body mass, were generated from whole-body BMC measurements. BMI was calculated as weight (kg) over height (m) squared. Physical activity was assessed, and three-day dietary records were taken at entry (baseline) and at 6 and 12 months.

RESULTS

No changes in BMD after 12 months were found in either the isoflavone-treated (treatment) group or the isoflavone-deficient (control) group. Other variables also remained essentially constant over the 12-month period, including normal menstrual patterns in both the treatment and control groups.

CONCLUSIONS

The isoflavone-rich soy preparation had no effects on BMC and BMD over a 12-month period in young healthy adult females with normal menses. An isoflavone-rich supplement appears to have little or no effect on bone in young adult women with normal ovarian function, at least over this 12-month study period.

Authors+Show Affiliations

Department of Nutrition, Schools of Public Health and Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA. jjb_anderson.umc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12356779

Citation

Anderson, John J B., et al. "Soy Isoflavones: No Effects On Bone Mineral Content and Bone Mineral Density in Healthy, Menstruating Young Adult Women After One Year." Journal of the American College of Nutrition, vol. 21, no. 5, 2002, pp. 388-93.
Anderson JJ, Chen X, Boass A, et al. Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year. J Am Coll Nutr. 2002;21(5):388-93.
Anderson, J. J., Chen, X., Boass, A., Symons, M., Kohlmeier, M., Renner, J. B., & Garner, S. C. (2002). Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year. Journal of the American College of Nutrition, 21(5), pp. 388-93.
Anderson JJ, et al. Soy Isoflavones: No Effects On Bone Mineral Content and Bone Mineral Density in Healthy, Menstruating Young Adult Women After One Year. J Am Coll Nutr. 2002;21(5):388-93. PubMed PMID: 12356779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year. AU - Anderson,John J B, AU - Chen,Xiaowei, AU - Boass,Agna, AU - Symons,Michael, AU - Kohlmeier,Martin, AU - Renner,Jordan B, AU - Garner,Sanford C, PY - 2002/10/3/pubmed PY - 2002/10/19/medline PY - 2002/10/3/entrez SP - 388 EP - 93 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 21 IS - 5 N2 - BACKGROUND: The effects of isoflavone-enriched soy protein on human bone mineral content (mass) and density in healthy, menstruating young adult females have not been examined in a comparative prospective investigation. Peri- and post-menopausal women have been reported to show beneficial effects of isoflavones on bone measurements. Therefore, young women may also be able to improve their accrual of peak bone mineral content (BMC) and bone mineral density (BMD) during the early adult years of bone consolidation with an isoflavone-enriched diet. OBJECTIVES: In this controlled, double-blind intervention, we tested the hypothesis that an isoflavone-rich soy protein diet increases BMC and BMD in young adult females over a period of one year in comparison to a control group receiving soy protein that has isoflavones removed. DESIGN: Young healthy women of any ethnic background, 21 to 25 years of age, were divided into two groups, placebo (n = 13) and supplement (n = 15). The soy protein supplement was enriched with isoflavones (approximately 90 mg of total isoflavones/day), whereas the control protein diet was isoflavone-deficient, even though it contained the same amount of soy protein and other ingredients as the isoflavone-rich diet. Dual-energy x-ray absorptiometric (DXA) measurements of BMC and BMD were made at baseline and at 6 and 12 months. DXA estimates of body composition, including fat mass and lean body mass, were generated from whole-body BMC measurements. BMI was calculated as weight (kg) over height (m) squared. Physical activity was assessed, and three-day dietary records were taken at entry (baseline) and at 6 and 12 months. RESULTS: No changes in BMD after 12 months were found in either the isoflavone-treated (treatment) group or the isoflavone-deficient (control) group. Other variables also remained essentially constant over the 12-month period, including normal menstrual patterns in both the treatment and control groups. CONCLUSIONS: The isoflavone-rich soy preparation had no effects on BMC and BMD over a 12-month period in young healthy adult females with normal menses. An isoflavone-rich supplement appears to have little or no effect on bone in young adult women with normal ovarian function, at least over this 12-month study period. SN - 0731-5724 UR - https://www.unboundmedicine.com/medline/citation/12356779/Soy_isoflavones:_no_effects_on_bone_mineral_content_and_bone_mineral_density_in_healthy_menstruating_young_adult_women_after_one_year_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2002.10719240 DB - PRIME DP - Unbound Medicine ER -