Tags

Type your tag names separated by a space and hit enter

Relationship between bilirubin UDP-glucuronosyl transferase 1A1 gene and neonatal hyperbilirubinemia.
Pediatr Res. 2002 Oct; 52(4):601-5.PR

Abstract

The variation rate within the coding region of UDP-glucuronosyl transferase 1A1 (UGT1A1) gene in Taiwan Chinese was found to be 29.3%. This study sought to determine whether that high variation rate of UGT1A1 gene is a risk factor for neonatal hyperbilirubinemia. The study subjects consisted of 123 newborn infants suffering from unconjugated hyperbilirubinemia who had no known risk factors for hyperbilirubinemia and 218 healthy control neonates. The promoter area, exons 1 to 4, coding region of exon 5, and the flanking intronic regions in UGT1A1 gene were determined by the PCR in all subjects. Wild UGT1A1 gene, variation in the promoter, variation at nucleotide 211, variation at nucleotide 1091, and compound heterozygous variation of UGT1A1 gene were found. The percentage of neonates with wild UGT1A1 gene and the percentage of neonates with variation at nucleotide 211 were significantly different between the study subjects and controls. The percentages with bilirubin >or=342 micro M (20.0 mg/dL) and with persistent hyperbilirubinemia in the subjects carrying homozygous variation at nucleotide 211 (Gly71Arg) were significantly higher than the neonates carrying wild type or other genotypes. In conclusion, this study has demonstrated that variation at nucleotide 211 of the UGT1A1 gene is a risk factor for the development of neonatal hyperbilirubinemia. Pediatricians should closely follow hyperbilirubinemic newborn infants who carry homozygous 211 G to A variation in UGT1A1 gene.

Authors+Show Affiliations

Department of Laboratory Medicine, Cathay General Hospital, No.280, Sec 4, Jen Ai Road, Taipei 106, Taiwan. pcsh@ms1.cgh.org.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12357057

Citation

Huang, Ching-Shan, et al. "Relationship Between Bilirubin UDP-glucuronosyl Transferase 1A1 Gene and Neonatal Hyperbilirubinemia." Pediatric Research, vol. 52, no. 4, 2002, pp. 601-5.
Huang CS, Chang PF, Huang MJ, et al. Relationship between bilirubin UDP-glucuronosyl transferase 1A1 gene and neonatal hyperbilirubinemia. Pediatr Res. 2002;52(4):601-5.
Huang, C. S., Chang, P. F., Huang, M. J., Chen, E. S., Hung, K. L., & Tsou, K. I. (2002). Relationship between bilirubin UDP-glucuronosyl transferase 1A1 gene and neonatal hyperbilirubinemia. Pediatric Research, 52(4), 601-5.
Huang CS, et al. Relationship Between Bilirubin UDP-glucuronosyl Transferase 1A1 Gene and Neonatal Hyperbilirubinemia. Pediatr Res. 2002;52(4):601-5. PubMed PMID: 12357057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between bilirubin UDP-glucuronosyl transferase 1A1 gene and neonatal hyperbilirubinemia. AU - Huang,Ching-Shan, AU - Chang,Pi-Feng, AU - Huang,May-Jen, AU - Chen,En-Sung, AU - Hung,Kun-Long, AU - Tsou,Kuo-Inn, PY - 2002/10/3/pubmed PY - 2003/3/5/medline PY - 2002/10/3/entrez SP - 601 EP - 5 JF - Pediatric research JO - Pediatr. Res. VL - 52 IS - 4 N2 - The variation rate within the coding region of UDP-glucuronosyl transferase 1A1 (UGT1A1) gene in Taiwan Chinese was found to be 29.3%. This study sought to determine whether that high variation rate of UGT1A1 gene is a risk factor for neonatal hyperbilirubinemia. The study subjects consisted of 123 newborn infants suffering from unconjugated hyperbilirubinemia who had no known risk factors for hyperbilirubinemia and 218 healthy control neonates. The promoter area, exons 1 to 4, coding region of exon 5, and the flanking intronic regions in UGT1A1 gene were determined by the PCR in all subjects. Wild UGT1A1 gene, variation in the promoter, variation at nucleotide 211, variation at nucleotide 1091, and compound heterozygous variation of UGT1A1 gene were found. The percentage of neonates with wild UGT1A1 gene and the percentage of neonates with variation at nucleotide 211 were significantly different between the study subjects and controls. The percentages with bilirubin >or=342 micro M (20.0 mg/dL) and with persistent hyperbilirubinemia in the subjects carrying homozygous variation at nucleotide 211 (Gly71Arg) were significantly higher than the neonates carrying wild type or other genotypes. In conclusion, this study has demonstrated that variation at nucleotide 211 of the UGT1A1 gene is a risk factor for the development of neonatal hyperbilirubinemia. Pediatricians should closely follow hyperbilirubinemic newborn infants who carry homozygous 211 G to A variation in UGT1A1 gene. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/12357057/Relationship_between_bilirubin_UDP_glucuronosyl_transferase_1A1_gene_and_neonatal_hyperbilirubinemia_ L2 - http://dx.doi.org/10.1203/00006450-200210000-00022 DB - PRIME DP - Unbound Medicine ER -