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Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass.
Acta Diabetol. 2002 Sep; 39(3):105-10.AD

Abstract

In obese people, an increase of plasma leptin levels is well-known and is seen as a consequence of the increased body fat mass. Moreover, a relationship between fasting concentrations of leptin and insulin has been described. Hyperinsulinemia is considered to be indicative of insulin resistance. We aimed at elucidating the interrelations between leptin, insulin and insulin resistance in type 2 diabetic patients. Under metabolic ward conditions, we investigated 21 moderately overweight men with type 2 diabetes. The patients had a mean age of 49.1 years, a mean body mass index (BMI) of 26.8 kg/m(2), and a mean diabetes duration of 82.5 months. All patients were treated with diet alone. We measured fasting leptin and insulin levels, body composition by determination of total body water, and insulin resistance by euglycemic hyperinsulinemic clamp technique. At univariate analysis, fasting leptin level significantly and positively correlated with BMI (r=0.49, p=0.02) and with fasting insulin (r=0.69, p=0.001), while it negatively correlated with the glucose disposal rate (r=-0.62, p=0.002). Furthermore, leptin was inversely correlated with HDL-cholesterol (r=-0.45, p=0.04). When excluding the influence of body fat mass or of BMI in partial correlation analysis, the correlations between leptin and insulin or insulin sensitivity remained significant. The relationship between insulin resistance (as measured directly in the clamp experiments) and leptin concentrations was also shown by subdividing the diabetic patients according to tertiles of insulin sensitivity. The highest fasting leptin levels were observed in those patients with the most expressed insulin resistance. Our data point to a functional relationship between insulin resistance and leptin concentrations in insulin-resistant type 2 diabetic men, independently of body composition. This relationship is believed to be mediated by insulin.

Authors+Show Affiliations

Institute of Clinical Metabolic Research, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12357293

Citation

Fischer, S, et al. "Insulin-resistant Patients With Type 2 Diabetes Mellitus Have Higher Serum Leptin Levels Independently of Body Fat Mass." Acta Diabetologica, vol. 39, no. 3, 2002, pp. 105-10.
Fischer S, Hanefeld M, Haffner SM, et al. Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass. Acta Diabetol. 2002;39(3):105-10.
Fischer, S., Hanefeld, M., Haffner, S. M., Fusch, C., Schwanebeck, U., Köhler, C., Fücker, K., & Julius, U. (2002). Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass. Acta Diabetologica, 39(3), 105-10.
Fischer S, et al. Insulin-resistant Patients With Type 2 Diabetes Mellitus Have Higher Serum Leptin Levels Independently of Body Fat Mass. Acta Diabetol. 2002;39(3):105-10. PubMed PMID: 12357293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass. AU - Fischer,S, AU - Hanefeld,M, AU - Haffner,S M, AU - Fusch,C, AU - Schwanebeck,U, AU - Köhler,C, AU - Fücker,K, AU - Julius,U, PY - 2002/10/3/pubmed PY - 2003/4/1/medline PY - 2002/10/3/entrez SP - 105 EP - 10 JF - Acta diabetologica JO - Acta Diabetol VL - 39 IS - 3 N2 - In obese people, an increase of plasma leptin levels is well-known and is seen as a consequence of the increased body fat mass. Moreover, a relationship between fasting concentrations of leptin and insulin has been described. Hyperinsulinemia is considered to be indicative of insulin resistance. We aimed at elucidating the interrelations between leptin, insulin and insulin resistance in type 2 diabetic patients. Under metabolic ward conditions, we investigated 21 moderately overweight men with type 2 diabetes. The patients had a mean age of 49.1 years, a mean body mass index (BMI) of 26.8 kg/m(2), and a mean diabetes duration of 82.5 months. All patients were treated with diet alone. We measured fasting leptin and insulin levels, body composition by determination of total body water, and insulin resistance by euglycemic hyperinsulinemic clamp technique. At univariate analysis, fasting leptin level significantly and positively correlated with BMI (r=0.49, p=0.02) and with fasting insulin (r=0.69, p=0.001), while it negatively correlated with the glucose disposal rate (r=-0.62, p=0.002). Furthermore, leptin was inversely correlated with HDL-cholesterol (r=-0.45, p=0.04). When excluding the influence of body fat mass or of BMI in partial correlation analysis, the correlations between leptin and insulin or insulin sensitivity remained significant. The relationship between insulin resistance (as measured directly in the clamp experiments) and leptin concentrations was also shown by subdividing the diabetic patients according to tertiles of insulin sensitivity. The highest fasting leptin levels were observed in those patients with the most expressed insulin resistance. Our data point to a functional relationship between insulin resistance and leptin concentrations in insulin-resistant type 2 diabetic men, independently of body composition. This relationship is believed to be mediated by insulin. SN - 0940-5429 UR - https://www.unboundmedicine.com/medline/citation/12357293/Insulin_resistant_patients_with_type_2_diabetes_mellitus_have_higher_serum_leptin_levels_independently_of_body_fat_mass_ L2 - https://dx.doi.org/10.1007/s005920200027 DB - PRIME DP - Unbound Medicine ER -