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Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus.
Acta Diabetol. 2002 Sep; 39(3):117-22.AD

Abstract

Diabetes is associated with a significant increase in thiobarbituric acid reactive substances (TBARS) which are considered as an index of endogenous lipid peroxidation. The human body has a complex antioxidant defense system that prevents the initiation of free radical chain reactions. We measured plasma TBARS levels, superoxide dismutase (SOD) and catalase (CAT) activities and compared their relation to the metabolic control of diabetes and diabetic microangiopathy. Sixty-four patients (19 men), aged 52.35+/-9.31 years with type 2 diabetes mellitus were included in the study. Thirty-six healthy subjects (12 men), aged 51.02+/-7.01 years formed the control group. TBARS levels and SOD activity were elevated in the diabetic group when compared with the control group (p<0.001 and p<0.00001, respectively). However CAT activity was significantly decreased in the diabetic group when compared with the control group (p<0.00001). Patients with diabetic nephropathy and retinopathy, but not neuropathy, had elevated TBARS levels but there was no statistically significant difference when compared with diabetic patients without microangiopathy (p>0.05). There was a positive correlation between plasma TBARS levels and SOD activity (r=0.770, p=0.0001) and a negative correlation between plasma TBARS levels and CAT activity (r=0.482, p=0.0001). There was also a negative correlation between SOD and CAT activities (r=-0.609, p=0.0001). We found significantly elevated TBARS levels in diabetic patients. We did not observe any correlation between TBARS levels and blood glucose and HbA(1c) levels. Elevated TBARS levels and SOD activity and decreased CAT activity may be due to a compensation mechanism of the body.

Authors+Show Affiliations

Department of Internal Medicine, Sahinbey Medical Center, Gaziantep University, School of Medicine, Gaziantep, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12357295

Citation

Turk, H M., et al. "Plasma Lipid Peroxidation Products and Antioxidant Enzyme Activities in Patients With Type 2 Diabetes Mellitus." Acta Diabetologica, vol. 39, no. 3, 2002, pp. 117-22.
Turk HM, Sevinc A, Camci C, et al. Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus. Acta Diabetol. 2002;39(3):117-22.
Turk, H. M., Sevinc, A., Camci, C., Cigli, A., Buyukberber, S., Savli, H., & Bayraktar, N. (2002). Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus. Acta Diabetologica, 39(3), 117-22.
Turk HM, et al. Plasma Lipid Peroxidation Products and Antioxidant Enzyme Activities in Patients With Type 2 Diabetes Mellitus. Acta Diabetol. 2002;39(3):117-22. PubMed PMID: 12357295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus. AU - Turk,H M, AU - Sevinc,A, AU - Camci,C, AU - Cigli,A, AU - Buyukberber,S, AU - Savli,H, AU - Bayraktar,N, PY - 2002/10/3/pubmed PY - 2003/4/1/medline PY - 2002/10/3/entrez SP - 117 EP - 22 JF - Acta diabetologica JO - Acta Diabetol VL - 39 IS - 3 N2 - Diabetes is associated with a significant increase in thiobarbituric acid reactive substances (TBARS) which are considered as an index of endogenous lipid peroxidation. The human body has a complex antioxidant defense system that prevents the initiation of free radical chain reactions. We measured plasma TBARS levels, superoxide dismutase (SOD) and catalase (CAT) activities and compared their relation to the metabolic control of diabetes and diabetic microangiopathy. Sixty-four patients (19 men), aged 52.35+/-9.31 years with type 2 diabetes mellitus were included in the study. Thirty-six healthy subjects (12 men), aged 51.02+/-7.01 years formed the control group. TBARS levels and SOD activity were elevated in the diabetic group when compared with the control group (p<0.001 and p<0.00001, respectively). However CAT activity was significantly decreased in the diabetic group when compared with the control group (p<0.00001). Patients with diabetic nephropathy and retinopathy, but not neuropathy, had elevated TBARS levels but there was no statistically significant difference when compared with diabetic patients without microangiopathy (p>0.05). There was a positive correlation between plasma TBARS levels and SOD activity (r=0.770, p=0.0001) and a negative correlation between plasma TBARS levels and CAT activity (r=0.482, p=0.0001). There was also a negative correlation between SOD and CAT activities (r=-0.609, p=0.0001). We found significantly elevated TBARS levels in diabetic patients. We did not observe any correlation between TBARS levels and blood glucose and HbA(1c) levels. Elevated TBARS levels and SOD activity and decreased CAT activity may be due to a compensation mechanism of the body. SN - 0940-5429 UR - https://www.unboundmedicine.com/medline/citation/12357295/Plasma_lipid_peroxidation_products_and_antioxidant_enzyme_activities_in_patients_with_type_2_diabetes_mellitus_ L2 - https://dx.doi.org/10.1007/s005920200029 DB - PRIME DP - Unbound Medicine ER -