Tags

Type your tag names separated by a space and hit enter

Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves.
Planta Med. 2002 Sep; 68(9):776-9.PM

Abstract

The effects of water-soluble extracts of artichoke (Cynara scolymus L.) leaves on taurolithocholate-induced cholestatic bile canalicular membrane distortions were studied in primary cultured rat hepatocytes using electron microscopy. Artichoke extracts at concentrations between 0.08 and 0.5 mg/ml were able to prevent the formation of bizarre canalicular membrane transformations in a dose-dependent manner when added simultaneously with the bile acid. However, prevention also occurred when the hepatocytes were preincubated with the extracts, indicating that absorption of the bile acid to components of the extracts was not involved. These results demonstrate that artichoke leaf extracts exert a potent anticholestatic action at least in the case of taurolithocholate. This effect may contribute to the overall hepatoprotective influence of this herbal formulation.

Authors+Show Affiliations

Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany. rgebhardt@medizine.uni-leipzig.de

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12357385

Citation

Gebhardt, R. "Prevention of Taurolithocholate-induced Hepatic Bile Canalicular Distortions By HPLC-characterized Extracts of Artichoke (Cynara Scolymus) Leaves." Planta Medica, vol. 68, no. 9, 2002, pp. 776-9.
Gebhardt R. Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves. Planta Med. 2002;68(9):776-9.
Gebhardt, R. (2002). Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves. Planta Medica, 68(9), 776-9.
Gebhardt R. Prevention of Taurolithocholate-induced Hepatic Bile Canalicular Distortions By HPLC-characterized Extracts of Artichoke (Cynara Scolymus) Leaves. Planta Med. 2002;68(9):776-9. PubMed PMID: 12357385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves. A1 - Gebhardt,R, PY - 2002/10/3/pubmed PY - 2002/12/27/medline PY - 2002/10/3/entrez SP - 776 EP - 9 JF - Planta medica JO - Planta Med VL - 68 IS - 9 N2 - The effects of water-soluble extracts of artichoke (Cynara scolymus L.) leaves on taurolithocholate-induced cholestatic bile canalicular membrane distortions were studied in primary cultured rat hepatocytes using electron microscopy. Artichoke extracts at concentrations between 0.08 and 0.5 mg/ml were able to prevent the formation of bizarre canalicular membrane transformations in a dose-dependent manner when added simultaneously with the bile acid. However, prevention also occurred when the hepatocytes were preincubated with the extracts, indicating that absorption of the bile acid to components of the extracts was not involved. These results demonstrate that artichoke leaf extracts exert a potent anticholestatic action at least in the case of taurolithocholate. This effect may contribute to the overall hepatoprotective influence of this herbal formulation. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/12357385/Prevention_of_taurolithocholate_induced_hepatic_bile_canalicular_distortions_by_HPLC_characterized_extracts_of_artichoke__Cynara_scolymus__leaves_ DB - PRIME DP - Unbound Medicine ER -