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Chemical analysis and antifungal activity of the essential oil of Calea clematidea.
Planta Med. 2002 Sep; 68(9):836-8.PM

Abstract

The chemical composition of the essential oils of Calea clematidea Baker obtained by hydrodistillation of the leaves and flowers was analysed by GC and GC/MS and the oils were assayed for their antifungal activities. The essential oil of the leaves showed a high content of a new natural epoxy terpenoid, named clemateol (ca. 70 %), with minor amounts of o-vanillin (6.5 %), spathulenol (4.2 %), alpha-terpinene (4.0 %), germacrene B (2.9 %), yomogi alcohol (1.8 %), (E)-caryophylene (1.7 %), m-cymenene (1.6 %), and alpha-gurjunene (1.5 %), while the essential oil of the flowers was characterized by a higher content of thymol methyl ether (ca. 80 %), with minor amounts of clemateol (4.8 %) and o-cymene (4.7 %). The antimicrobial activity of the oils was also evaluated against dermatophytes for their possible use in pharmaceutical preparations for topical applications. The oil of the leaves (MIC > 3.57 mg/ml), clemateol (MIC > 1.52 mg/ml), and the alcohol 2 (MIC > 2.82 mg/ml) showed a moderate antifungal activity against Trichophyton tonsurans, Trichophyton rubrum, Trichophyton menthagrophytes var. i nterdigitale, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis and Microsporum nanum.

Authors+Show Affiliations

Flach A
Departamento de Química da Universidade Federal de Santa Maria, Campus-Camobi, Santa Maria, RS, Brazil.
Gregel B
No affiliation info available
Simionatto E
No affiliation info available
da Silva UF
No affiliation info available
Zanatta N
No affiliation info available
Morel AF
No affiliation info available
Linares CE
No affiliation info available
Alves SH
No affiliation info available

MeSH

Antifungal AgentsAsteraceaeEpidermophytonEpoxy CompoundsFlowersMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMicrosporumMitosporic FungiMolecular StructureOils, VolatilePlant ExtractsPlant LeavesTerpenesTrichophyton

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12357399

Citation

Flach, Adriana, et al. "Chemical Analysis and Antifungal Activity of the Essential Oil of Calea Clematidea." Planta Medica, vol. 68, no. 9, 2002, pp. 836-8.
Flach A, Gregel B, Simionatto E, et al. Chemical analysis and antifungal activity of the essential oil of Calea clematidea. Planta Med. 2002;68(9):836-8.
Flach, A., Gregel, B., Simionatto, E., da Silva, U. F., Zanatta, N., Morel, A. F., Linares, C. E., & Alves, S. H. (2002). Chemical analysis and antifungal activity of the essential oil of Calea clematidea. Planta Medica, 68(9), 836-8.
Flach A, et al. Chemical Analysis and Antifungal Activity of the Essential Oil of Calea Clematidea. Planta Med. 2002;68(9):836-8. PubMed PMID: 12357399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical analysis and antifungal activity of the essential oil of Calea clematidea. AU - Flach,Adriana, AU - Gregel,Birget, AU - Simionatto,Euclésio, AU - da Silva,Ubiratan F, AU - Zanatta,Nilo, AU - Morel,Ademir F, AU - Linares,Carlos E, AU - Alves,Sydney H, PY - 2002/10/3/pubmed PY - 2002/12/27/medline PY - 2002/10/3/entrez SP - 836 EP - 8 JF - Planta medica JO - Planta Med VL - 68 IS - 9 N2 - The chemical composition of the essential oils of Calea clematidea Baker obtained by hydrodistillation of the leaves and flowers was analysed by GC and GC/MS and the oils were assayed for their antifungal activities. The essential oil of the leaves showed a high content of a new natural epoxy terpenoid, named clemateol (ca. 70 %), with minor amounts of o-vanillin (6.5 %), spathulenol (4.2 %), alpha-terpinene (4.0 %), germacrene B (2.9 %), yomogi alcohol (1.8 %), (E)-caryophylene (1.7 %), m-cymenene (1.6 %), and alpha-gurjunene (1.5 %), while the essential oil of the flowers was characterized by a higher content of thymol methyl ether (ca. 80 %), with minor amounts of clemateol (4.8 %) and o-cymene (4.7 %). The antimicrobial activity of the oils was also evaluated against dermatophytes for their possible use in pharmaceutical preparations for topical applications. The oil of the leaves (MIC > 3.57 mg/ml), clemateol (MIC > 1.52 mg/ml), and the alcohol 2 (MIC > 2.82 mg/ml) showed a moderate antifungal activity against Trichophyton tonsurans, Trichophyton rubrum, Trichophyton menthagrophytes var. i nterdigitale, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis and Microsporum nanum. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/12357399/Chemical_analysis_and_antifungal_activity_of_the_essential_oil_of_Calea_clematidea_ DB - PRIME DP - Unbound Medicine ER -