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Freezing of gait in postmortem-confirmed atypical parkinsonism.
Mov Disord. 2002 Sep; 17(5):1041-5.MD

Abstract

The frequency and pathophysiology of freezing of gait (FoG) in atypical parkinsonism is unknown. We analysed the frequency of FoG in postmortem-confirmed atypical parkinsonian disorders (APD) comprising corticobasal degeneration (CBD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Sixty-six patients with pathologically confirmed APD (CBD, n = 13; DLB, n = 14; MSA, n = 15; PSP, n = 24) formed the basis for a multicenter clinicopathological study. Clinical features at first and last clinical visit were abstracted from patient records on standardized forms following strict instructions. At the first visit (median 36 months after symptom onset), 24% of APD had FoG (CBD, 8%; DLB, 21%; PSP, 25%; MSA, 40%). Logistic regression analysis showed a significant association of FoG and urinary incontinence (P = 0.04) at first visit. At last visit, 47% of APD had FoG (CBD, 25%; PSP, 53%; DLB, 54%; MSA, 54%). Clinicopathological correlation based on routine postmortem examination failed to identify a consistent neuropathological substrate of FoG. This study demonstrates that (1) FoG is common in APD, and (2) urinary incontinence is significantly associated with FoG in these disorders. Whether FoG and urinary incontinence share similar neuropathological substrates remains to be determined by future studies.

Authors+Show Affiliations

Department of Neurology, University Hospital Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12360556

Citation

Müller, Jörg, et al. "Freezing of Gait in Postmortem-confirmed Atypical Parkinsonism." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 17, no. 5, 2002, pp. 1041-5.
Müller J, Seppi K, Stefanova N, et al. Freezing of gait in postmortem-confirmed atypical parkinsonism. Mov Disord. 2002;17(5):1041-5.
Müller, J., Seppi, K., Stefanova, N., Poewe, W., Litvan, I., & Wenning, G. K. (2002). Freezing of gait in postmortem-confirmed atypical parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society, 17(5), 1041-5.
Müller J, et al. Freezing of Gait in Postmortem-confirmed Atypical Parkinsonism. Mov Disord. 2002;17(5):1041-5. PubMed PMID: 12360556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Freezing of gait in postmortem-confirmed atypical parkinsonism. AU - Müller,Jörg, AU - Seppi,Klaus, AU - Stefanova,Nadia, AU - Poewe,Werner, AU - Litvan,Irene, AU - Wenning,Gregor K, PY - 2002/10/3/pubmed PY - 2003/1/9/medline PY - 2002/10/3/entrez SP - 1041 EP - 5 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 17 IS - 5 N2 - The frequency and pathophysiology of freezing of gait (FoG) in atypical parkinsonism is unknown. We analysed the frequency of FoG in postmortem-confirmed atypical parkinsonian disorders (APD) comprising corticobasal degeneration (CBD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Sixty-six patients with pathologically confirmed APD (CBD, n = 13; DLB, n = 14; MSA, n = 15; PSP, n = 24) formed the basis for a multicenter clinicopathological study. Clinical features at first and last clinical visit were abstracted from patient records on standardized forms following strict instructions. At the first visit (median 36 months after symptom onset), 24% of APD had FoG (CBD, 8%; DLB, 21%; PSP, 25%; MSA, 40%). Logistic regression analysis showed a significant association of FoG and urinary incontinence (P = 0.04) at first visit. At last visit, 47% of APD had FoG (CBD, 25%; PSP, 53%; DLB, 54%; MSA, 54%). Clinicopathological correlation based on routine postmortem examination failed to identify a consistent neuropathological substrate of FoG. This study demonstrates that (1) FoG is common in APD, and (2) urinary incontinence is significantly associated with FoG in these disorders. Whether FoG and urinary incontinence share similar neuropathological substrates remains to be determined by future studies. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/12360556/Freezing_of_gait_in_postmortem_confirmed_atypical_parkinsonism_ L2 - https://doi.org/10.1002/mds.10234 DB - PRIME DP - Unbound Medicine ER -