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[Essential to discover hereditary colorectal and endometrial cancer. Mutations in "HNPCC individuals" can cause several different tumors].
Lakartidningen. 2002 Aug 22; 99(34):3296-300.L

Abstract

Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is one of our most common hereditary cancer syndromes and confers an increased risk for several tumor types, with the greatest lifetime risks being for colorectal cancer and endometrial cancer. Hereditary mutations in one of several mismatch-repair (MMR) genes cause the syndrome, and 39 such mutations, involving the genes MLH1, MSH2 and MSH6, have been been characterized in Sweden. Screening programs for HNPCC have been shown to be cost-effective and to prevent cancer. Identification of HNPCC individuals thus allows prevention of additional tumors in the patient as well as in the family.

Authors+Show Affiliations

Onkologiska kliniken, Universitetssjukhuset i Lund. Mef.Nilbert@onk.lu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

swe

PubMed ID

12362848

Citation

Nilbert, Mef, et al. "[Essential to Discover Hereditary Colorectal and Endometrial Cancer. Mutations in "HNPCC Individuals" Can Cause Several Different Tumors]." Lakartidningen, vol. 99, no. 34, 2002, pp. 3296-300.
Nilbert M, Grönberg H, Lindblom A. [Essential to discover hereditary colorectal and endometrial cancer. Mutations in "HNPCC individuals" can cause several different tumors]. Lakartidningen. 2002;99(34):3296-300.
Nilbert, M., Grönberg, H., & Lindblom, A. (2002). [Essential to discover hereditary colorectal and endometrial cancer. Mutations in "HNPCC individuals" can cause several different tumors]. Lakartidningen, 99(34), 3296-300.
Nilbert M, Grönberg H, Lindblom A. [Essential to Discover Hereditary Colorectal and Endometrial Cancer. Mutations in "HNPCC Individuals" Can Cause Several Different Tumors]. Lakartidningen. 2002 Aug 22;99(34):3296-300. PubMed PMID: 12362848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Essential to discover hereditary colorectal and endometrial cancer. Mutations in "HNPCC individuals" can cause several different tumors]. AU - Nilbert,Mef, AU - Grönberg,Henrik, AU - Lindblom,Annika, PY - 2002/10/5/pubmed PY - 2002/10/22/medline PY - 2002/10/5/entrez SP - 3296 EP - 300 JF - Lakartidningen JO - Lakartidningen VL - 99 IS - 34 N2 - Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is one of our most common hereditary cancer syndromes and confers an increased risk for several tumor types, with the greatest lifetime risks being for colorectal cancer and endometrial cancer. Hereditary mutations in one of several mismatch-repair (MMR) genes cause the syndrome, and 39 such mutations, involving the genes MLH1, MSH2 and MSH6, have been been characterized in Sweden. Screening programs for HNPCC have been shown to be cost-effective and to prevent cancer. Identification of HNPCC individuals thus allows prevention of additional tumors in the patient as well as in the family. SN - 0023-7205 UR - https://www.unboundmedicine.com/medline/citation/12362848/[Essential_to_discover_hereditary_colorectal_and_endometrial_cancer__Mutations_in_"HNPCC_individuals"_can_cause_several_different_tumors]_ L2 - http://www.diseaseinfosearch.org/result/3345 DB - PRIME DP - Unbound Medicine ER -