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Plasma adiponectin concentrations in children: relationships with obesity and insulinemia.
J Clin Endocrinol Metab 2002; 87(10):4652-6JC

Abstract

Adiponectin, a novel adipokine with anti-inflammatory and insulin-sensitizing properties, has been found to have independent negative associations with obesity and hyperinsulinemia/insulin resistance in adults. We measured fasting plasma adiponectin and insulin concentrations and body composition (dual-energy x-ray absorptiometry or doubly labeled water) in 30 5-yr-old (11 boys and 19 girls) and 53 10-yr-old (17 boys and 36 girls) Pima Indian children. A subgroup of 20 children (5 boys and 15 girls) had all measurements at both 5 and 10 yr of age. Cross-sectionally, plasma adiponectin concentrations were negatively correlated with percentage body fat and fasting plasma insulin concentrations at both 5 yr (r = -0.35, P = 0.06, r = -0.42, P = 0.02) and 10 yr (r = -0.46, P = 0.001, r = -0.38, P = 0.005) of age. At age 10 yr, percentage body fat (P = 0.03) but not fasting plasma insulin (P = 0.59) was independently associated with fasting plasma adiponectin concentrations. Longitudinally, plasma adiponectin concentrations decreased with increasing adiposity. In summary, these results confirm our previously reported findings in adults of an inverse relationship between plasma adiponectin concentrations and adiposity in children. Longitudinal analyses indicated that hypoadiponectinemia is a consequence of the development of obesity in childhood. We did not find evidence that adiponectin is an early mediator of obesity-induced insulin resistance, a preliminary observation that needs to be confirmed in studies using a more direct measurement of insulin action than the one used in this investigation.

Authors+Show Affiliations

Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA. nstefan@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12364452

Citation

Stefan, Norbert, et al. "Plasma Adiponectin Concentrations in Children: Relationships With Obesity and Insulinemia." The Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 10, 2002, pp. 4652-6.
Stefan N, Bunt JC, Salbe AD, et al. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab. 2002;87(10):4652-6.
Stefan, N., Bunt, J. C., Salbe, A. D., Funahashi, T., Matsuzawa, Y., & Tataranni, P. A. (2002). Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. The Journal of Clinical Endocrinology and Metabolism, 87(10), pp. 4652-6.
Stefan N, et al. Plasma Adiponectin Concentrations in Children: Relationships With Obesity and Insulinemia. J Clin Endocrinol Metab. 2002;87(10):4652-6. PubMed PMID: 12364452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. AU - Stefan,Norbert, AU - Bunt,Joy C, AU - Salbe,Arline D, AU - Funahashi,Tohru, AU - Matsuzawa,Yuji, AU - Tataranni,P Antonio, PY - 2002/10/5/pubmed PY - 2002/11/1/medline PY - 2002/10/5/entrez SP - 4652 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 87 IS - 10 N2 - Adiponectin, a novel adipokine with anti-inflammatory and insulin-sensitizing properties, has been found to have independent negative associations with obesity and hyperinsulinemia/insulin resistance in adults. We measured fasting plasma adiponectin and insulin concentrations and body composition (dual-energy x-ray absorptiometry or doubly labeled water) in 30 5-yr-old (11 boys and 19 girls) and 53 10-yr-old (17 boys and 36 girls) Pima Indian children. A subgroup of 20 children (5 boys and 15 girls) had all measurements at both 5 and 10 yr of age. Cross-sectionally, plasma adiponectin concentrations were negatively correlated with percentage body fat and fasting plasma insulin concentrations at both 5 yr (r = -0.35, P = 0.06, r = -0.42, P = 0.02) and 10 yr (r = -0.46, P = 0.001, r = -0.38, P = 0.005) of age. At age 10 yr, percentage body fat (P = 0.03) but not fasting plasma insulin (P = 0.59) was independently associated with fasting plasma adiponectin concentrations. Longitudinally, plasma adiponectin concentrations decreased with increasing adiposity. In summary, these results confirm our previously reported findings in adults of an inverse relationship between plasma adiponectin concentrations and adiposity in children. Longitudinal analyses indicated that hypoadiponectinemia is a consequence of the development of obesity in childhood. We did not find evidence that adiponectin is an early mediator of obesity-induced insulin resistance, a preliminary observation that needs to be confirmed in studies using a more direct measurement of insulin action than the one used in this investigation. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/12364452/Plasma_adiponectin_concentrations_in_children:_relationships_with_obesity_and_insulinemia_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2002-020694 DB - PRIME DP - Unbound Medicine ER -