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Effects of hormone replacement therapy and hepatic lipase polymorphism on serum lipid profiles in postmenopausal Japanese women.
J Clin Endocrinol Metab. 2002 Oct; 87(10):4766-70.JC

Abstract

The purpose of this study was to evaluate the relationships among hepatic lipase (HL) polymorphism, serum lipids, lipoproteins, and remnant-like particle cholesterol (RLP-C) and to determine the effects of hormone replacement therapy (HRT). We assessed the HL polymorphism in 209 postmenopausal Japanese women. Levels of serum total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides, apolipoprotein (Apo) AI, Apo B, Apo E, Apo CII, Apo CIII, and RLP-C were measured before and after 3 months of HRT. The frequency of each genotype was 32% for -514 C/C, 41% for C/T, and 27% for T/T. Subjects with the C/T and T/T genotypes had higher levels of HDL cholesterol and Apo AI than those with the C/C genotype. Those with the T/T genotype had higher levels of RLP-C than those with the C/C or C/T genotype. Serum total cholesterol, LDL cholesterol, Apo B, Apo E, and Apo CII were decreased, and HDL cholesterol and Apo AI were increased significantly in all genotypes after 3 months of HRT. There were no differences in these changes with genotype. The HL polymorphism was associated with higher levels of HDL cholesterol, Apo AI, and RLP-C, and the HL gene variation may contribute to HL activity and affect serum lipoprotein metabolism. Effects of HRT on serum lipids, lipoproteins, and remnant lipoprotein metabolism were unaffected by the HL polymorphism.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Toride Kyodo General Hospital, Toride 3020022, Japan. pv2t-sigi@asahi-net.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12364471

Citation

Somekawa, Yoshiaki, et al. "Effects of Hormone Replacement Therapy and Hepatic Lipase Polymorphism On Serum Lipid Profiles in Postmenopausal Japanese Women." The Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 10, 2002, pp. 4766-70.
Somekawa Y, Umeki H, Kobayashi K, et al. Effects of hormone replacement therapy and hepatic lipase polymorphism on serum lipid profiles in postmenopausal Japanese women. J Clin Endocrinol Metab. 2002;87(10):4766-70.
Somekawa, Y., Umeki, H., Kobayashi, K., Tomura, S., Aso, T., & Hamaguchi, H. (2002). Effects of hormone replacement therapy and hepatic lipase polymorphism on serum lipid profiles in postmenopausal Japanese women. The Journal of Clinical Endocrinology and Metabolism, 87(10), 4766-70.
Somekawa Y, et al. Effects of Hormone Replacement Therapy and Hepatic Lipase Polymorphism On Serum Lipid Profiles in Postmenopausal Japanese Women. J Clin Endocrinol Metab. 2002;87(10):4766-70. PubMed PMID: 12364471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hormone replacement therapy and hepatic lipase polymorphism on serum lipid profiles in postmenopausal Japanese women. AU - Somekawa,Yoshiaki, AU - Umeki,Hidenori, AU - Kobayashi,Kimiko, AU - Tomura,Sigeo, AU - Aso,Takeshi, AU - Hamaguchi,Hideo, PY - 2002/10/5/pubmed PY - 2002/11/1/medline PY - 2002/10/5/entrez SP - 4766 EP - 70 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 87 IS - 10 N2 - The purpose of this study was to evaluate the relationships among hepatic lipase (HL) polymorphism, serum lipids, lipoproteins, and remnant-like particle cholesterol (RLP-C) and to determine the effects of hormone replacement therapy (HRT). We assessed the HL polymorphism in 209 postmenopausal Japanese women. Levels of serum total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides, apolipoprotein (Apo) AI, Apo B, Apo E, Apo CII, Apo CIII, and RLP-C were measured before and after 3 months of HRT. The frequency of each genotype was 32% for -514 C/C, 41% for C/T, and 27% for T/T. Subjects with the C/T and T/T genotypes had higher levels of HDL cholesterol and Apo AI than those with the C/C genotype. Those with the T/T genotype had higher levels of RLP-C than those with the C/C or C/T genotype. Serum total cholesterol, LDL cholesterol, Apo B, Apo E, and Apo CII were decreased, and HDL cholesterol and Apo AI were increased significantly in all genotypes after 3 months of HRT. There were no differences in these changes with genotype. The HL polymorphism was associated with higher levels of HDL cholesterol, Apo AI, and RLP-C, and the HL gene variation may contribute to HL activity and affect serum lipoprotein metabolism. Effects of HRT on serum lipids, lipoproteins, and remnant lipoprotein metabolism were unaffected by the HL polymorphism. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/12364471/Effects_of_hormone_replacement_therapy_and_hepatic_lipase_polymorphism_on_serum_lipid_profiles_in_postmenopausal_Japanese_women_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2002-020245 DB - PRIME DP - Unbound Medicine ER -