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[Antiganglioside autoantibody profiles in Guillain-Barré syndrome].
Ann Biol Clin (Paris). 2002 Sep-Oct; 60(5):589-97.AB

Abstract

We established anti-ganglioside antibody profiles in GBS and studied the frequency, fine specificity and clinical correlate. IgG and IgM antibodies to 8 gangliosides were tested by immunodot-blot in 249 consecutive patients with Guillain-Barré syndrome with large variability in clinical expression, referred to our laboratory over a 8-year period. IgG and IgM anti-GM1 antibodies were measured by Elisa. Thin-layer chromatography overlayed by serum was used to control positivity. 89/249 GBS (36%) had characteristic anti-ganglioside antibody profile. Isotypes were, IgG (62%), IgG + IgM (26%) and IgM (12%). Antecedent infections were found in 62% of GBS included more frequently Campylobacter jejuni and cytomegalovirus. Various autoantibody profiles were described with an immunodominant ganglioside. We detected 6 characteristic anti-ganglioside profiles with fine specificity and immunodominant ganglioside corresponding to 6 immuno-clinical variants of GBS: 1) anti-GM1 and GD1b IgG and IgG > IgM in the acute motor axonal neuropathy after Campylobacter jejuni infection in 41 GBS; 2) anti-GD1a IgG in 6 severe motor axonal GBS after Campylobacter jejuni infection; 3) selectively anti-GQ1b IgG in 17 typical Miller Fisher syndrome with areflexia, ataxia and ophthalmoplegia; 4) anti- GT1b ganglioside and polysialogangliosides IgG (n = 9) in two separate cranial nerve variants, ophthalmoplegic SGB and lower cranial nerve variants depending upon the presenting deficit; 5) anti-GD1b IgG in 5 pure ataxic sensory GBS (4%); 6) anti-GM2 IgM in 11 severe GBS with antecedent CMV infection (8%). 34 GBS (14%) had low levels of anti-GM1 and GD1b IgM antibodies which are not disease specific and may simply represent part of the naturally occurring autoantibody population or a secondary response to disease. 126 GBS (50%) had no antibodies, predominantly in classical form. Associations between isotype, fine specificity and clinical presentation permit the definition of homogeneous immuno-clinical variants. Various autoantibody profiles with diagnostic and prognostic value are easy to perform by immunodot blot in acute peripheral neuropathies.

Authors+Show Affiliations

Service d'immunologie et de neuro-immunologie, Hôpital neurologique et neurochirurgical, 69394 Lyon cedex 03.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

12368145

Citation

Caudie, C, et al. "[Antiganglioside Autoantibody Profiles in Guillain-Barré Syndrome]." Annales De Biologie Clinique, vol. 60, no. 5, 2002, pp. 589-97.
Caudie C, Vial C, Bancel J, et al. [Antiganglioside autoantibody profiles in Guillain-Barré syndrome]. Ann Biol Clin (Paris). 2002;60(5):589-97.
Caudie, C., Vial, C., Bancel, J., Petiot, P., Antoine, J. C., & Gonnaud, P. M. (2002). [Antiganglioside autoantibody profiles in Guillain-Barré syndrome]. Annales De Biologie Clinique, 60(5), 589-97.
Caudie C, et al. [Antiganglioside Autoantibody Profiles in Guillain-Barré Syndrome]. Ann Biol Clin (Paris). 2002 Sep-Oct;60(5):589-97. PubMed PMID: 12368145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antiganglioside autoantibody profiles in Guillain-Barré syndrome]. AU - Caudie,C, AU - Vial,C, AU - Bancel,J, AU - Petiot,P, AU - Antoine,J C, AU - Gonnaud,P M, PY - 2002/10/9/pubmed PY - 2002/11/26/medline PY - 2002/10/9/entrez SP - 589 EP - 97 JF - Annales de biologie clinique JO - Ann Biol Clin (Paris) VL - 60 IS - 5 N2 - We established anti-ganglioside antibody profiles in GBS and studied the frequency, fine specificity and clinical correlate. IgG and IgM antibodies to 8 gangliosides were tested by immunodot-blot in 249 consecutive patients with Guillain-Barré syndrome with large variability in clinical expression, referred to our laboratory over a 8-year period. IgG and IgM anti-GM1 antibodies were measured by Elisa. Thin-layer chromatography overlayed by serum was used to control positivity. 89/249 GBS (36%) had characteristic anti-ganglioside antibody profile. Isotypes were, IgG (62%), IgG + IgM (26%) and IgM (12%). Antecedent infections were found in 62% of GBS included more frequently Campylobacter jejuni and cytomegalovirus. Various autoantibody profiles were described with an immunodominant ganglioside. We detected 6 characteristic anti-ganglioside profiles with fine specificity and immunodominant ganglioside corresponding to 6 immuno-clinical variants of GBS: 1) anti-GM1 and GD1b IgG and IgG > IgM in the acute motor axonal neuropathy after Campylobacter jejuni infection in 41 GBS; 2) anti-GD1a IgG in 6 severe motor axonal GBS after Campylobacter jejuni infection; 3) selectively anti-GQ1b IgG in 17 typical Miller Fisher syndrome with areflexia, ataxia and ophthalmoplegia; 4) anti- GT1b ganglioside and polysialogangliosides IgG (n = 9) in two separate cranial nerve variants, ophthalmoplegic SGB and lower cranial nerve variants depending upon the presenting deficit; 5) anti-GD1b IgG in 5 pure ataxic sensory GBS (4%); 6) anti-GM2 IgM in 11 severe GBS with antecedent CMV infection (8%). 34 GBS (14%) had low levels of anti-GM1 and GD1b IgM antibodies which are not disease specific and may simply represent part of the naturally occurring autoantibody population or a secondary response to disease. 126 GBS (50%) had no antibodies, predominantly in classical form. Associations between isotype, fine specificity and clinical presentation permit the definition of homogeneous immuno-clinical variants. Various autoantibody profiles with diagnostic and prognostic value are easy to perform by immunodot blot in acute peripheral neuropathies. SN - 0003-3898 UR - https://www.unboundmedicine.com/medline/citation/12368145/[Antiganglioside_autoantibody_profiles_in_Guillain_Barré_syndrome]_ L2 - http://www.jle.com/medline.md?issn=0003-3898&vol=60&iss=5&page=589 DB - PRIME DP - Unbound Medicine ER -