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Effects of dietary salt changes on renal renin-angiotensin system in rats.
Am J Physiol Renal Physiol. 2002 Nov; 283(5):F995-1002.AJ

Abstract

Renin (RA) and angiotensin-converting enzyme (ACE) activities and angiotensinogen, ANG I, and ANG II levels were measured in the kidney (cortex and medulla) and plasma of Wistar-Kyoto rats on a low-sodium (LS; 0.025% NaCl; n = 8), normal-sodium (NS; 1% NaCl; n = 7), or high-sodium (HS; 8% NaCl; n = 7) diet for 21 days. RA, ANG I, and ANG II levels increased in a manner inversely related to sodium content of the diet in both plasma and renal tissues. The LS diet resulted in a 16-, 2.8-, and 1.8-fold increase in plasma RA, ANG I, and ANG II levels, respectively, compared with those in HS rats. In the renal cortex and medulla, RA, ANG I, and ANG II levels were also increased by diminution of dietary salt content but, in contrast to plasma, ANG II levels increased much more than RA or ANG I levels [5.4 (cortex)- and 4.7 (medulla)-fold compared with HS rats]. In summary, we demonstrated variations of ANG II levels in the kidney during dietary salt modifications. Our results confirm that RA and ACE activity are not the steps limiting intrarenal ANG II levels. Nevertheless, despite RA and ACE activity differences between renal cortex and medulla, ANG I and ANG II levels are equivalent in these two tissues; these results argue against a compartmentalization of RAS in these two intrarenal areas.

Authors+Show Affiliations

Institut de Pharmacologie, Faculté de Médecine, Université Louis Pasteur, 67085 Strasbourg, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12372775

Citation

Ingert, Catherine, et al. "Effects of Dietary Salt Changes On Renal Renin-angiotensin System in Rats." American Journal of Physiology. Renal Physiology, vol. 283, no. 5, 2002, pp. F995-1002.
Ingert C, Grima M, Coquard C, et al. Effects of dietary salt changes on renal renin-angiotensin system in rats. Am J Physiol Renal Physiol. 2002;283(5):F995-1002.
Ingert, C., Grima, M., Coquard, C., Barthelmebs, M., & Imbs, J. L. (2002). Effects of dietary salt changes on renal renin-angiotensin system in rats. American Journal of Physiology. Renal Physiology, 283(5), F995-1002.
Ingert C, et al. Effects of Dietary Salt Changes On Renal Renin-angiotensin System in Rats. Am J Physiol Renal Physiol. 2002;283(5):F995-1002. PubMed PMID: 12372775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary salt changes on renal renin-angiotensin system in rats. AU - Ingert,Catherine, AU - Grima,Michèle, AU - Coquard,Catherine, AU - Barthelmebs,Mariette, AU - Imbs,Jean-Louis, PY - 2002/10/10/pubmed PY - 2002/11/26/medline PY - 2002/10/10/entrez SP - F995 EP - 1002 JF - American journal of physiology. Renal physiology JO - Am. J. Physiol. Renal Physiol. VL - 283 IS - 5 N2 - Renin (RA) and angiotensin-converting enzyme (ACE) activities and angiotensinogen, ANG I, and ANG II levels were measured in the kidney (cortex and medulla) and plasma of Wistar-Kyoto rats on a low-sodium (LS; 0.025% NaCl; n = 8), normal-sodium (NS; 1% NaCl; n = 7), or high-sodium (HS; 8% NaCl; n = 7) diet for 21 days. RA, ANG I, and ANG II levels increased in a manner inversely related to sodium content of the diet in both plasma and renal tissues. The LS diet resulted in a 16-, 2.8-, and 1.8-fold increase in plasma RA, ANG I, and ANG II levels, respectively, compared with those in HS rats. In the renal cortex and medulla, RA, ANG I, and ANG II levels were also increased by diminution of dietary salt content but, in contrast to plasma, ANG II levels increased much more than RA or ANG I levels [5.4 (cortex)- and 4.7 (medulla)-fold compared with HS rats]. In summary, we demonstrated variations of ANG II levels in the kidney during dietary salt modifications. Our results confirm that RA and ACE activity are not the steps limiting intrarenal ANG II levels. Nevertheless, despite RA and ACE activity differences between renal cortex and medulla, ANG I and ANG II levels are equivalent in these two tissues; these results argue against a compartmentalization of RAS in these two intrarenal areas. SN - 1931-857X UR - https://www.unboundmedicine.com/medline/citation/12372775/Effects_of_dietary_salt_changes_on_renal_renin_angiotensin_system_in_rats_ L2 - http://www.physiology.org/doi/full/10.1152/ajprenal.00321.2001?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -