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Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats.
Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1003-10.AJ

Abstract

This study was designed to determine the involvement of AT(1) receptors in the uptake of ANG II in the kidney of rats exposed to differing salt intake. Male Wistar-Kyoto rats were treated with a normal-salt (NS; 1% NaCl, n = 7) or a low-salt (LS; 0.025% NaCl, n = 7) diet combined with (LS+Los, n = 7; NS+Los, n = 7) or without losartan (30 mg. kg(-1). day(-1)), an AT(1) receptor antagonist. Renin (RA) and angiotensin-converting enzyme (ACE) activities and angiotensinogen, ANG I, and ANG II levels were measured in plasma, renal cortex, and medulla. In LS rats, in both plasma and renal cortex, the increase in RA was associated with an increase in ANG I and ANG II levels compared with NS rats, but intrarenal ANG II levels increased more than ANG I levels. In NS+Los rats, the increase in RA in plasma was followed by a marked increase in plasma ANG I and ANG II levels compared with NS rats whereas in the kidney the increase of renal RA was followed by a decrease of the levels of these peptides. The same pattern was observed in LS+Los rats, but the decrease in renal ANG II levels was much more pronounced in LS+Los rats than in NS+Los rats. Our results suggest that the increase in renal ANG II levels after salt restriction results mainly from an uptake of ANG II, via AT(1) receptors. Such elevated intrarenal ANG II levels could contribute to maintain sodium and fluid balance and arterial blood pressure during salt-deficiency states.

Authors+Show Affiliations

Institut de Pharmacologie, Faculté de Médecine, Université Louis Pasteur, 67085 Strasbourg France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12372776

Citation

Ingert, Catherine, et al. "Contribution of Angiotensin II Internalization to Intrarenal Angiotensin II Levels in Rats." American Journal of Physiology. Renal Physiology, vol. 283, no. 5, 2002, pp. F1003-10.
Ingert C, Grima M, Coquard C, et al. Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats. Am J Physiol Renal Physiol. 2002;283(5):F1003-10.
Ingert, C., Grima, M., Coquard, C., Barthelmebs, M., & Imbs, J. L. (2002). Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats. American Journal of Physiology. Renal Physiology, 283(5), F1003-10.
Ingert C, et al. Contribution of Angiotensin II Internalization to Intrarenal Angiotensin II Levels in Rats. Am J Physiol Renal Physiol. 2002;283(5):F1003-10. PubMed PMID: 12372776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats. AU - Ingert,Catherine, AU - Grima,Michèle, AU - Coquard,Catherine, AU - Barthelmebs,Mariette, AU - Imbs,Jean-Louis, PY - 2002/10/10/pubmed PY - 2002/11/26/medline PY - 2002/10/10/entrez SP - F1003 EP - 10 JF - American journal of physiology. Renal physiology JO - Am. J. Physiol. Renal Physiol. VL - 283 IS - 5 N2 - This study was designed to determine the involvement of AT(1) receptors in the uptake of ANG II in the kidney of rats exposed to differing salt intake. Male Wistar-Kyoto rats were treated with a normal-salt (NS; 1% NaCl, n = 7) or a low-salt (LS; 0.025% NaCl, n = 7) diet combined with (LS+Los, n = 7; NS+Los, n = 7) or without losartan (30 mg. kg(-1). day(-1)), an AT(1) receptor antagonist. Renin (RA) and angiotensin-converting enzyme (ACE) activities and angiotensinogen, ANG I, and ANG II levels were measured in plasma, renal cortex, and medulla. In LS rats, in both plasma and renal cortex, the increase in RA was associated with an increase in ANG I and ANG II levels compared with NS rats, but intrarenal ANG II levels increased more than ANG I levels. In NS+Los rats, the increase in RA in plasma was followed by a marked increase in plasma ANG I and ANG II levels compared with NS rats whereas in the kidney the increase of renal RA was followed by a decrease of the levels of these peptides. The same pattern was observed in LS+Los rats, but the decrease in renal ANG II levels was much more pronounced in LS+Los rats than in NS+Los rats. Our results suggest that the increase in renal ANG II levels after salt restriction results mainly from an uptake of ANG II, via AT(1) receptors. Such elevated intrarenal ANG II levels could contribute to maintain sodium and fluid balance and arterial blood pressure during salt-deficiency states. SN - 1931-857X UR - https://www.unboundmedicine.com/medline/citation/12372776/Contribution_of_angiotensin_II_internalization_to_intrarenal_angiotensin_II_levels_in_rats_ L2 - http://www.physiology.org/doi/full/10.1152/ajprenal.00322.2001?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -