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IgG and IgA antibody levels to cow's milk are low at age 10 years in children born preterm.
J Allergy Clin Immunol 2002; 110(4):658-63JA

Abstract

BACKGROUND

Both innate and specific defenses of the preterm infant are even less developed than those of term infants, and the immune systems of preterm infants might be skewed differently at birth. Their immune responses to food antigens started early in life might therefore differ from those of term infants.

OBJECTIVE

We sought to compare antibody levels to cow's milk, ovalbumin, and gliadin at age 10 years in children who had been born either preterm or at term.

METHODS

IgG and IgA isotype antibodies to whole cow's milk, beta-lactoglobulin, alpha-casein, and ovalbumin, as well as IgG antibody levels to gliadin and to tetanus and diphtheria toxoids, were measured for a group of 62 children born preterm and 61 control subjects born at term. These children were studied at the same time for atopy.

RESULTS

Children born preterm had markedly lower levels of antibodies to cow's milk and to its protein fractions (P <.0001 for IgA and IgG antibodies to cow's milk and alpha-casein and IgG beta-lactoglobulin antibodies). IgG gliadin antibodies were also significantly lower in the preterm group (P =.03), although the difference was not significant for IgG ovalbumin antibodies. In the preterm group both those born before gestational week 30 and those given cow's milk-based formula early (before day 50) had the lowest levels of cow's milk antibodies. In the preterm group atopy was associated with low levels of IgG cow's milk antibodies but with high levels of IgG ovalbumin antibodies.

CONCLUSIONS

Early introduction of food antigens into the immature gastrointestinal tract of preterm infants might result in tolerance. The presence of less atopy in these children might also be a result of tolerance development.

Authors+Show Affiliations

Hospital for Children and Adolescents, University of Helsinki, FIN-0029 HUS, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12373277

Citation

Siltanen, Mirjami, et al. "IgG and IgA Antibody Levels to Cow's Milk Are Low at Age 10 Years in Children Born Preterm." The Journal of Allergy and Clinical Immunology, vol. 110, no. 4, 2002, pp. 658-63.
Siltanen M, Kajosaari M, Savilahti EM, et al. IgG and IgA antibody levels to cow's milk are low at age 10 years in children born preterm. J Allergy Clin Immunol. 2002;110(4):658-63.
Siltanen, M., Kajosaari, M., Savilahti, E. M., Pohjavuori, M., & Savilahti, E. (2002). IgG and IgA antibody levels to cow's milk are low at age 10 years in children born preterm. The Journal of Allergy and Clinical Immunology, 110(4), pp. 658-63.
Siltanen M, et al. IgG and IgA Antibody Levels to Cow's Milk Are Low at Age 10 Years in Children Born Preterm. J Allergy Clin Immunol. 2002;110(4):658-63. PubMed PMID: 12373277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgG and IgA antibody levels to cow's milk are low at age 10 years in children born preterm. AU - Siltanen,Mirjami, AU - Kajosaari,Merja, AU - Savilahti,Emma M, AU - Pohjavuori,Maija, AU - Savilahti,Erkki, PY - 2002/10/10/pubmed PY - 2002/11/1/medline PY - 2002/10/10/entrez SP - 658 EP - 63 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 110 IS - 4 N2 - BACKGROUND: Both innate and specific defenses of the preterm infant are even less developed than those of term infants, and the immune systems of preterm infants might be skewed differently at birth. Their immune responses to food antigens started early in life might therefore differ from those of term infants. OBJECTIVE: We sought to compare antibody levels to cow's milk, ovalbumin, and gliadin at age 10 years in children who had been born either preterm or at term. METHODS: IgG and IgA isotype antibodies to whole cow's milk, beta-lactoglobulin, alpha-casein, and ovalbumin, as well as IgG antibody levels to gliadin and to tetanus and diphtheria toxoids, were measured for a group of 62 children born preterm and 61 control subjects born at term. These children were studied at the same time for atopy. RESULTS: Children born preterm had markedly lower levels of antibodies to cow's milk and to its protein fractions (P <.0001 for IgA and IgG antibodies to cow's milk and alpha-casein and IgG beta-lactoglobulin antibodies). IgG gliadin antibodies were also significantly lower in the preterm group (P =.03), although the difference was not significant for IgG ovalbumin antibodies. In the preterm group both those born before gestational week 30 and those given cow's milk-based formula early (before day 50) had the lowest levels of cow's milk antibodies. In the preterm group atopy was associated with low levels of IgG cow's milk antibodies but with high levels of IgG ovalbumin antibodies. CONCLUSIONS: Early introduction of food antigens into the immature gastrointestinal tract of preterm infants might result in tolerance. The presence of less atopy in these children might also be a result of tolerance development. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/12373277/IgG_and_IgA_antibody_levels_to_cow's_milk_are_low_at_age_10_years_in_children_born_preterm_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674902001665 DB - PRIME DP - Unbound Medicine ER -