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Intermittent versus continuous renal replacement therapy for acute renal failure in intensive care units: results from a multicenter prospective epidemiological survey.
Intensive Care Med. 2002 Oct; 28(10):1411-8.IC

Abstract

OBJECTIVES

To describe the current practice of hemodialysis in acute renal failure (ARF) and to estimate the impact of hemodialysis modality on patient outcome.

DESIGN

Prospective multicenter observational study conducted from March 1996 to May 1997.

SETTING

The 28 multidisciplinary ICUs in the Rhône-Alpes region in France.

PATIENTS

The 587 patients who required hemodialysis.

MEASUREMENTS AND RESULTS

Patients were followed until hospital discharge. Among the 587 patients 354 received continuous (CRRT) and 233 intermittent (IRRT) renal replacement therapy as first choice. CRRT patients had a higher number of organ dysfunctions on admission and at the time of ARF and higher SAPS II at time of ARF. Mortality was 79% in the CRRT group and 59% in the IRRT group. Logistic regression analysis showed decreased patient survival to be associated with SAPS II on admission, oliguria, admission from hospital or emergency room, number of days between admission and ARF, cardiac dysfunction at time of ARF, and ischemic ARF. No underlying disease or nonfatal disease, and absence of hepatic dysfunction were associated with an increase in patient survival. The type of renal replacement therapy was not significantly associated with outcome.

CONCLUSIONS

Renal replacement therapy mode was not found to have any prognostic value. Randomized controlled trials should be undertaken to assess this important question.

Authors+Show Affiliations

Service de Réanimation Médicale et Assistance Respiratoire, Hôpital de la Croix Rousse, 103 grande rue de la croix rousse, 69317 Lyon, France. claude.guerin@chu-lyon.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12373465

Citation

Guérin, Claude, et al. "Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure in Intensive Care Units: Results From a Multicenter Prospective Epidemiological Survey." Intensive Care Medicine, vol. 28, no. 10, 2002, pp. 1411-8.
Guérin C, Girard R, Selli JM, et al. Intermittent versus continuous renal replacement therapy for acute renal failure in intensive care units: results from a multicenter prospective epidemiological survey. Intensive Care Med. 2002;28(10):1411-8.
Guérin, C., Girard, R., Selli, J. M., & Ayzac, L. (2002). Intermittent versus continuous renal replacement therapy for acute renal failure in intensive care units: results from a multicenter prospective epidemiological survey. Intensive Care Medicine, 28(10), 1411-8.
Guérin C, et al. Intermittent Versus Continuous Renal Replacement Therapy for Acute Renal Failure in Intensive Care Units: Results From a Multicenter Prospective Epidemiological Survey. Intensive Care Med. 2002;28(10):1411-8. PubMed PMID: 12373465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intermittent versus continuous renal replacement therapy for acute renal failure in intensive care units: results from a multicenter prospective epidemiological survey. AU - Guérin,Claude, AU - Girard,Raphaele, AU - Selli,Jean Marc, AU - Ayzac,Louis, Y1 - 2002/08/17/ PY - 2001/05/11/received PY - 2002/07/03/accepted PY - 2002/10/10/pubmed PY - 2003/3/7/medline PY - 2002/10/10/entrez SP - 1411 EP - 8 JF - Intensive care medicine JO - Intensive Care Med VL - 28 IS - 10 N2 - OBJECTIVES: To describe the current practice of hemodialysis in acute renal failure (ARF) and to estimate the impact of hemodialysis modality on patient outcome. DESIGN: Prospective multicenter observational study conducted from March 1996 to May 1997. SETTING: The 28 multidisciplinary ICUs in the Rhône-Alpes region in France. PATIENTS: The 587 patients who required hemodialysis. MEASUREMENTS AND RESULTS: Patients were followed until hospital discharge. Among the 587 patients 354 received continuous (CRRT) and 233 intermittent (IRRT) renal replacement therapy as first choice. CRRT patients had a higher number of organ dysfunctions on admission and at the time of ARF and higher SAPS II at time of ARF. Mortality was 79% in the CRRT group and 59% in the IRRT group. Logistic regression analysis showed decreased patient survival to be associated with SAPS II on admission, oliguria, admission from hospital or emergency room, number of days between admission and ARF, cardiac dysfunction at time of ARF, and ischemic ARF. No underlying disease or nonfatal disease, and absence of hepatic dysfunction were associated with an increase in patient survival. The type of renal replacement therapy was not significantly associated with outcome. CONCLUSIONS: Renal replacement therapy mode was not found to have any prognostic value. Randomized controlled trials should be undertaken to assess this important question. SN - 0342-4642 UR - https://www.unboundmedicine.com/medline/citation/12373465/Intermittent_versus_continuous_renal_replacement_therapy_for_acute_renal_failure_in_intensive_care_units:_results_from_a_multicenter_prospective_epidemiological_survey_ L2 - https://dx.doi.org/10.1007/s00134-002-1433-0 DB - PRIME DP - Unbound Medicine ER -