Tags

Type your tag names separated by a space and hit enter

Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.
Arch Intern Med. 2002 Oct 14; 162(18):2113-23.AI

Abstract

BACKGROUND

Conventional symptomatic treatments for osteoarthritis do not favorably affect disease progression. The aim of this randomized, placebo-controlled trial was to determine whether long-term (3-year) treatment with glucosamine sulfate can modify the progression of joint structure and symptom changes in knee osteoarthritis, as previously suggested.

METHODS

Two hundred two patients with knee osteoarthritis (using American College of Rheumatology criteria) were randomized to receive oral glucosamine sulfate, 1500 mg once a day, or placebo. Changes in radiographic minimum joint space width were measured in the medial compartment of the tibiofemoral joint, and symptoms were assessed using the algo-functional indexes of Lequesne and WOMAC (Western Ontario and McMaster Universities).

RESULTS

Osteoarthritis was of mild to moderate severity at enrollment, with average joint space widths of slightly less than 4 mm and a Lequesne index score of less than 9 points. Progressive joint space narrowing with placebo use was -0.19 mm (95% confidence interval, -0.29 to -0.09 mm) after 3 years. Conversely, there was no average change with glucosamine sulfate use (0.04 mm; 95% confidence interval, -0.06 to 0.14 mm), with a significant difference between groups (P =.001). Fewer patients treated with glucosamine sulfate experienced predefined severe narrowings (>0.5 mm): 5% vs 14% (P =.05). Symptoms improved modestly with placebo use but as much as 20% to 25% with glucosamine sulfate use, with significant final differences on the Lequesne index and the WOMAC total index and pain, function, and stiffness subscales. Safety was good and without differences between groups.

CONCLUSION

Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.

Authors+Show Affiliations

Department of Medicine and Rheumatology, Charles University, Prague, Czech Republic. pavelka@revma.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12374520

Citation

Pavelká, Karel, et al. "Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis: a 3-year, Randomized, Placebo-controlled, Double-blind Study." Archives of Internal Medicine, vol. 162, no. 18, 2002, pp. 2113-23.
Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002;162(18):2113-23.
Pavelká, K., Gatterová, J., Olejarová, M., Machacek, S., Giacovelli, G., & Rovati, L. C. (2002). Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Archives of Internal Medicine, 162(18), 2113-23.
Pavelká K, et al. Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis: a 3-year, Randomized, Placebo-controlled, Double-blind Study. Arch Intern Med. 2002 Oct 14;162(18):2113-23. PubMed PMID: 12374520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. AU - Pavelká,Karel, AU - Gatterová,Jindriska, AU - Olejarová,Marta, AU - Machacek,Stanislav, AU - Giacovelli,Giampaolo, AU - Rovati,Lucio C, PY - 2002/10/11/pubmed PY - 2002/11/26/medline PY - 2002/10/11/entrez SP - 2113 EP - 23 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 162 IS - 18 N2 - BACKGROUND: Conventional symptomatic treatments for osteoarthritis do not favorably affect disease progression. The aim of this randomized, placebo-controlled trial was to determine whether long-term (3-year) treatment with glucosamine sulfate can modify the progression of joint structure and symptom changes in knee osteoarthritis, as previously suggested. METHODS: Two hundred two patients with knee osteoarthritis (using American College of Rheumatology criteria) were randomized to receive oral glucosamine sulfate, 1500 mg once a day, or placebo. Changes in radiographic minimum joint space width were measured in the medial compartment of the tibiofemoral joint, and symptoms were assessed using the algo-functional indexes of Lequesne and WOMAC (Western Ontario and McMaster Universities). RESULTS: Osteoarthritis was of mild to moderate severity at enrollment, with average joint space widths of slightly less than 4 mm and a Lequesne index score of less than 9 points. Progressive joint space narrowing with placebo use was -0.19 mm (95% confidence interval, -0.29 to -0.09 mm) after 3 years. Conversely, there was no average change with glucosamine sulfate use (0.04 mm; 95% confidence interval, -0.06 to 0.14 mm), with a significant difference between groups (P =.001). Fewer patients treated with glucosamine sulfate experienced predefined severe narrowings (>0.5 mm): 5% vs 14% (P =.05). Symptoms improved modestly with placebo use but as much as 20% to 25% with glucosamine sulfate use, with significant final differences on the Lequesne index and the WOMAC total index and pain, function, and stiffness subscales. Safety was good and without differences between groups. CONCLUSION: Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/12374520/Glucosamine_sulfate_use_and_delay_of_progression_of_knee_osteoarthritis:_a_3_year_randomized_placebo_controlled_double_blind_study_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/162/pg/2113 DB - PRIME DP - Unbound Medicine ER -