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Cardiac malformations associated with the Holt-Oram syndrome--report on a family and review of the literature.
Thorac Cardiovasc Surg 2002; 50(5):312-4TC

Abstract

The Holt-Oram syndrome (HOS) is characterized by mild-to-severe congenital cardiac defects and skeletal abnormalities of the upper limb. The most common cardiac disorder is an ostium secundum atrial septal defect (ASD), followed by ventricular septal defect (VSD) and ostium primum ASD. Electrocardiographic abnormalities, such as various degrees of atrioventricular block, have also been reported. In addition, hypoplastic peripheral vessels of the upper limbs have been observed. Here, we will report about a family with three sons having HOS, and we will detail the cardiac spectrum of HOS as reported in the literature.

Authors+Show Affiliations

Universität Leipzig, Herzzentrum, Klinik für Herzchirurgie, Germany. Tbossert11@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

12375192

Citation

Bossert, T, et al. "Cardiac Malformations Associated With the Holt-Oram Syndrome--report On a Family and Review of the Literature." The Thoracic and Cardiovascular Surgeon, vol. 50, no. 5, 2002, pp. 312-4.
Bossert T, Walther T, Gummert J, et al. Cardiac malformations associated with the Holt-Oram syndrome--report on a family and review of the literature. Thorac Cardiovasc Surg. 2002;50(5):312-4.
Bossert, T., Walther, T., Gummert, J., Hubald, R., Kostelka, M., & Mohr, F. W. (2002). Cardiac malformations associated with the Holt-Oram syndrome--report on a family and review of the literature. The Thoracic and Cardiovascular Surgeon, 50(5), pp. 312-4.
Bossert T, et al. Cardiac Malformations Associated With the Holt-Oram Syndrome--report On a Family and Review of the Literature. Thorac Cardiovasc Surg. 2002;50(5):312-4. PubMed PMID: 12375192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac malformations associated with the Holt-Oram syndrome--report on a family and review of the literature. AU - Bossert,T, AU - Walther,T, AU - Gummert,J, AU - Hubald,R, AU - Kostelka,M, AU - Mohr,F W, PY - 2002/10/11/pubmed PY - 2003/2/25/medline PY - 2002/10/11/entrez SP - 312 EP - 4 JF - The Thoracic and cardiovascular surgeon JO - Thorac Cardiovasc Surg VL - 50 IS - 5 N2 - The Holt-Oram syndrome (HOS) is characterized by mild-to-severe congenital cardiac defects and skeletal abnormalities of the upper limb. The most common cardiac disorder is an ostium secundum atrial septal defect (ASD), followed by ventricular septal defect (VSD) and ostium primum ASD. Electrocardiographic abnormalities, such as various degrees of atrioventricular block, have also been reported. In addition, hypoplastic peripheral vessels of the upper limbs have been observed. Here, we will report about a family with three sons having HOS, and we will detail the cardiac spectrum of HOS as reported in the literature. SN - 0171-6425 UR - https://www.unboundmedicine.com/medline/citation/12375192/Cardiac_malformations_associated_with_the_Holt_Oram_syndrome__report_on_a_family_and_review_of_the_literature_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-34573 DB - PRIME DP - Unbound Medicine ER -