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[Pesticide exposure and Parkinson's syndrome - the epidemiological and experimental evidence].
Nervenarzt. 2002 Oct; 73(10):982-9.N

Abstract

Retrospective case-control studies among patients with idiopathic Parkinson's syndrome (IPS) show a positive association to the existence of a - mostly premorbid - exposure to pesticides. In acute pesticide intoxications, usually symptoms other than parkinsonism are found. Therefore, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) continues to be the agent best documented both experimentally and clinically to cause a clinical syndrome comparable to IPS. It is debated whether still unknown effects between exogenous pesticide exposure and the xenobiotic enzyme system may lead to IPS in single genetically susceptible individuals. In practice, the present data on the problem of pesticide exposure in IPS are irrelevant for medicolegal considerations.

Authors+Show Affiliations

Klinik für Neurologie mit klinischer Neurophysiologie, Klinikum Lippe-Lemgo, Germany. peter.vieregge@klinikum-lippe.de

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

12376887

Citation

Vieregge, P. "[Pesticide Exposure and Parkinson's Syndrome - the Epidemiological and Experimental Evidence]." Der Nervenarzt, vol. 73, no. 10, 2002, pp. 982-9.
Vieregge P. [Pesticide exposure and Parkinson's syndrome - the epidemiological and experimental evidence]. Nervenarzt. 2002;73(10):982-9.
Vieregge, P. (2002). [Pesticide exposure and Parkinson's syndrome - the epidemiological and experimental evidence]. Der Nervenarzt, 73(10), 982-9.
Vieregge P. [Pesticide Exposure and Parkinson's Syndrome - the Epidemiological and Experimental Evidence]. Nervenarzt. 2002;73(10):982-9. PubMed PMID: 12376887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pesticide exposure and Parkinson's syndrome - the epidemiological and experimental evidence]. A1 - Vieregge,P, PY - 2002/10/12/pubmed PY - 2003/4/16/medline PY - 2002/10/12/entrez SP - 982 EP - 9 JF - Der Nervenarzt JO - Nervenarzt VL - 73 IS - 10 N2 - Retrospective case-control studies among patients with idiopathic Parkinson's syndrome (IPS) show a positive association to the existence of a - mostly premorbid - exposure to pesticides. In acute pesticide intoxications, usually symptoms other than parkinsonism are found. Therefore, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) continues to be the agent best documented both experimentally and clinically to cause a clinical syndrome comparable to IPS. It is debated whether still unknown effects between exogenous pesticide exposure and the xenobiotic enzyme system may lead to IPS in single genetically susceptible individuals. In practice, the present data on the problem of pesticide exposure in IPS are irrelevant for medicolegal considerations. SN - 0028-2804 UR - https://www.unboundmedicine.com/medline/citation/12376887/[Pesticide_exposure_and_Parkinson's_syndrome___the_epidemiological_and_experimental_evidence]_ L2 - https://dx.doi.org/10.1007/s00115-002-1394-0 DB - PRIME DP - Unbound Medicine ER -