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Treatment of depression in diabetes: impact on mood and medical outcome.

Abstract

Depression is prevalent as a co-morbid condition in diabetes. The efficacy of depression treatment with either pharmacological agents or psychotherapy has been demonstrated in the few available controlled trials. Depression has been associated with poor glycemic control and with accelerated rates of coronary heart disease in diabetic patients. Reported depression treatment trials demonstrate benefits of depression remission on glycemic control as well as mood and the potential for improvement in the course and outcome of diabetes. Because adverse effects of pharmacological agents on glycemic control have been observed, optimal therapies that improve both depression and measures of diabetes are still being sought. This review critically examines the efficacy of depression treatment in diabetes patients, the effects of depression treatment on the medical condition, and methodological issues important in the performance of treatment trials in the patient population.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA. lustmanp@psychiatry.wustl.edu

    Source

    Journal of psychosomatic research 53:4 2002 Oct pg 917-24

    MeSH

    Behavior Therapy
    Clinical Trials as Topic
    Comorbidity
    Depressive Disorder
    Diabetes Mellitus
    Fluoxetine
    Humans
    Mood Disorders
    Serotonin Uptake Inhibitors
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    12377304

    Citation

    Lustman, Patrick J., and Ray E. Clouse. "Treatment of Depression in Diabetes: Impact On Mood and Medical Outcome." Journal of Psychosomatic Research, vol. 53, no. 4, 2002, pp. 917-24.
    Lustman PJ, Clouse RE. Treatment of depression in diabetes: impact on mood and medical outcome. J Psychosom Res. 2002;53(4):917-24.
    Lustman, P. J., & Clouse, R. E. (2002). Treatment of depression in diabetes: impact on mood and medical outcome. Journal of Psychosomatic Research, 53(4), pp. 917-24.
    Lustman PJ, Clouse RE. Treatment of Depression in Diabetes: Impact On Mood and Medical Outcome. J Psychosom Res. 2002;53(4):917-24. PubMed PMID: 12377304.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Treatment of depression in diabetes: impact on mood and medical outcome. AU - Lustman,Patrick J, AU - Clouse,Ray E, PY - 2002/10/16/pubmed PY - 2003/4/19/medline PY - 2002/10/16/entrez SP - 917 EP - 24 JF - Journal of psychosomatic research JO - J Psychosom Res VL - 53 IS - 4 N2 - Depression is prevalent as a co-morbid condition in diabetes. The efficacy of depression treatment with either pharmacological agents or psychotherapy has been demonstrated in the few available controlled trials. Depression has been associated with poor glycemic control and with accelerated rates of coronary heart disease in diabetic patients. Reported depression treatment trials demonstrate benefits of depression remission on glycemic control as well as mood and the potential for improvement in the course and outcome of diabetes. Because adverse effects of pharmacological agents on glycemic control have been observed, optimal therapies that improve both depression and measures of diabetes are still being sought. This review critically examines the efficacy of depression treatment in diabetes patients, the effects of depression treatment on the medical condition, and methodological issues important in the performance of treatment trials in the patient population. SN - 0022-3999 UR - https://www.unboundmedicine.com/medline/citation/12377304/Treatment_of_depression_in_diabetes:_impact_on_mood_and_medical_outcome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022399902004166 DB - PRIME DP - Unbound Medicine ER -