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Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.

Abstract

The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD. These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

1237925

Citation

Hine, B, et al. "Differential Effect of Cannabinol and Cannabidiol On THC-induced Responses During Abstinence in Morphine-dependent Rats." Research Communications in Chemical Pathology and Pharmacology, vol. 12, no. 1, 1975, pp. 185-8.
Hine B, Torrelio M, Gershon S. Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats. Res Commun Chem Pathol Pharmacol. 1975;12(1):185-8.
Hine, B., Torrelio, M., & Gershon, S. (1975). Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats. Research Communications in Chemical Pathology and Pharmacology, 12(1), pp. 185-8.
Hine B, Torrelio M, Gershon S. Differential Effect of Cannabinol and Cannabidiol On THC-induced Responses During Abstinence in Morphine-dependent Rats. Res Commun Chem Pathol Pharmacol. 1975;12(1):185-8. PubMed PMID: 1237925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats. AU - Hine,B, AU - Torrelio,M, AU - Gershon,S, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 185 EP - 8 JF - Research communications in chemical pathology and pharmacology JO - Res. Commun. Chem. Pathol. Pharmacol. VL - 12 IS - 1 N2 - The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD. These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification. SN - 0034-5164 UR - https://www.unboundmedicine.com/medline/citation/1237925/Differential_effect_of_cannabinol_and_cannabidiol_on_THC_induced_responses_during_abstinence_in_morphine_dependent_rats_ DB - PRIME DP - Unbound Medicine ER -