Tags

Type your tag names separated by a space and hit enter

The apolipoprotein epsilon4 gene is associated with elevated risk of normal tension glaucoma.
Mol Vis. 2002 Oct 14; 8:389-93.MV

Abstract

PURPOSE

Inheritance of a particular apolipoprotein E gene polymorphism, the epsilon4 allele, has been associated with elevated risk for Alzheimer's disease and a poor outcome following head injury. The neuronal injury associated with Alzheimer's disease and brain injury may have a number of similarities with the nerve cell changes associated with glaucoma. Thus, we have investigated the association of inheritance of apolipoprotein E allelic isoforms (epsilon2, [epsilon]3, and epsilon4) with relative risk for different forms of glaucoma.

METHODS

Apolipoprotein E genotype was examined in a Tasmanian population sample comprised of glaucoma sufferers with elevated or normal intraocular pressure and compared to a control sample of elderly Tasmanians without glaucoma.

RESULTS

Approximately twice as many normal tension (38.0%) and high tension (34.2%) glaucoma cases possessed an epsilon4 allele compared to control cases (18.9%). The odds of epsilon4 carriers having normal tension glaucoma were significantly greater than for epsilon3 homozygotes (odds ratio 2.45, 95% confidence interval [1.02-5.91]) even after adjusting for age and gender (odd ratio 2.87 [1.02-8.05]). The increased odds of high tension glaucoma among [epsilon]4 allele carriers were not significant (adjusted odds ratio 1.53 [0.64-3.68]).

CONCLUSIONS

The data indicate that, in the Tasmanian population, inheritance of the [epsilon]4 allele is associated with elevated risk for glaucomatous changes that are not related to increased intraocular pressure.

Authors+Show Affiliations

Vickers JC
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. James.Vickers@utas.edu.au
Craig JE
No affiliation info available
Stankovich J
No affiliation info available
McCormack GH
No affiliation info available
West AK
No affiliation info available
Dickinson JL
No affiliation info available
McCartney PJ
No affiliation info available
Coote MA
No affiliation info available
Healey DL
No affiliation info available
Mackey DA
No affiliation info available

MeSH

AgedAged, 80 and overAllelesApolipoprotein E4Apolipoproteins EAustraliaDNAGenotypeGlaucoma, Open-AngleHumansIntraocular PressurePolymerase Chain ReactionRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12379839

Citation

Vickers, James C., et al. "The Apolipoprotein Epsilon4 Gene Is Associated With Elevated Risk of Normal Tension Glaucoma." Molecular Vision, vol. 8, 2002, pp. 389-93.
Vickers JC, Craig JE, Stankovich J, et al. The apolipoprotein epsilon4 gene is associated with elevated risk of normal tension glaucoma. Mol Vis. 2002;8:389-93.
Vickers, J. C., Craig, J. E., Stankovich, J., McCormack, G. H., West, A. K., Dickinson, J. L., McCartney, P. J., Coote, M. A., Healey, D. L., & Mackey, D. A. (2002). The apolipoprotein epsilon4 gene is associated with elevated risk of normal tension glaucoma. Molecular Vision, 8, 389-93.
Vickers JC, et al. The Apolipoprotein Epsilon4 Gene Is Associated With Elevated Risk of Normal Tension Glaucoma. Mol Vis. 2002 Oct 14;8:389-93. PubMed PMID: 12379839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The apolipoprotein epsilon4 gene is associated with elevated risk of normal tension glaucoma. AU - Vickers,James C, AU - Craig,Jamie E, AU - Stankovich,Jim, AU - McCormack,Graeme H, AU - West,Adrian K, AU - Dickinson,Joanne L, AU - McCartney,Paul J, AU - Coote,Michael A, AU - Healey,Danielle L, AU - Mackey,David A, Y1 - 2002/10/14/ PY - 2002/10/16/pubmed PY - 2002/11/26/medline PY - 2002/10/16/entrez SP - 389 EP - 93 JF - Molecular vision JO - Mol Vis VL - 8 N2 - PURPOSE: Inheritance of a particular apolipoprotein E gene polymorphism, the epsilon4 allele, has been associated with elevated risk for Alzheimer's disease and a poor outcome following head injury. The neuronal injury associated with Alzheimer's disease and brain injury may have a number of similarities with the nerve cell changes associated with glaucoma. Thus, we have investigated the association of inheritance of apolipoprotein E allelic isoforms (epsilon2, [epsilon]3, and epsilon4) with relative risk for different forms of glaucoma. METHODS: Apolipoprotein E genotype was examined in a Tasmanian population sample comprised of glaucoma sufferers with elevated or normal intraocular pressure and compared to a control sample of elderly Tasmanians without glaucoma. RESULTS: Approximately twice as many normal tension (38.0%) and high tension (34.2%) glaucoma cases possessed an epsilon4 allele compared to control cases (18.9%). The odds of epsilon4 carriers having normal tension glaucoma were significantly greater than for epsilon3 homozygotes (odds ratio 2.45, 95% confidence interval [1.02-5.91]) even after adjusting for age and gender (odd ratio 2.87 [1.02-8.05]). The increased odds of high tension glaucoma among [epsilon]4 allele carriers were not significant (adjusted odds ratio 1.53 [0.64-3.68]). CONCLUSIONS: The data indicate that, in the Tasmanian population, inheritance of the [epsilon]4 allele is associated with elevated risk for glaucomatous changes that are not related to increased intraocular pressure. SN - 1090-0535 UR - https://www.unboundmedicine.com/medline/citation/12379839/The_apolipoprotein_epsilon4_gene_is_associated_with_elevated_risk_of_normal_tension_glaucoma_ DB - PRIME DP - Unbound Medicine ER -