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Human herpesvirus 6 infection and cytomegalovirus-specific lymphoproliferative responses in allogeneic stem cell transplant recipients.
Bone Marrow Transplant. 2002 Oct; 30(8):521-6.BM

Abstract

The aim of this study was to investigate the effects of HHV-6 DNAemia on the CMV specific lymphoproliferative response after allogeneic stem cell transplantation. Twenty-one allogeneic stem cell transplantation (allo-SCT) patients were included in the study. The patients were either CMV seropositive and/or had CMV seropositive donors. We studied the effects of HHV-6 infection, documented by PCR, on CMV-specific lymphocyte proliferation response and on CMV infection documented by PCR. HHV-6 DNAemia correlated with the absence of CMV-specific lymphocyte proliferation responses after allo-SCT. Three of nine patients with persistent HHV-6 DNA had a CMV-specific lymphocyte proliferative response compared to 11 of 12 patients without persistent HHV-6 DNAemia (P = 0.02). Patients with higher HHV-6 DNA levels (>100 copies) were more likely than those with lower copy numbers not to develop a CMV-specific immune response (six of nine vs one of eight; P < 0.05). Patients who were repeatedly HHV-6 positive in three or more consecutive blood samples were also more likely to need repeated courses of preemptive antiviral therapy against CMV during the first 6 months after transplantation (P < 0.001). Our data indicate the possibility that HHV-6 can suppress the development of CMV-specific immune responses and thereby could predispose to development of late CMV disease.

Authors+Show Affiliations

Department of Hematology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12379892

Citation

Wang, F-Z, et al. "Human Herpesvirus 6 Infection and Cytomegalovirus-specific Lymphoproliferative Responses in Allogeneic Stem Cell Transplant Recipients." Bone Marrow Transplantation, vol. 30, no. 8, 2002, pp. 521-6.
Wang FZ, Larsson K, Linde A, et al. Human herpesvirus 6 infection and cytomegalovirus-specific lymphoproliferative responses in allogeneic stem cell transplant recipients. Bone Marrow Transplant. 2002;30(8):521-6.
Wang, F. Z., Larsson, K., Linde, A., & Ljungman, P. (2002). Human herpesvirus 6 infection and cytomegalovirus-specific lymphoproliferative responses in allogeneic stem cell transplant recipients. Bone Marrow Transplantation, 30(8), 521-6.
Wang FZ, et al. Human Herpesvirus 6 Infection and Cytomegalovirus-specific Lymphoproliferative Responses in Allogeneic Stem Cell Transplant Recipients. Bone Marrow Transplant. 2002;30(8):521-6. PubMed PMID: 12379892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human herpesvirus 6 infection and cytomegalovirus-specific lymphoproliferative responses in allogeneic stem cell transplant recipients. AU - Wang,F-Z, AU - Larsson,K, AU - Linde,A, AU - Ljungman,P, PY - 2001/09/04/received PY - 2002/06/11/accepted PY - 2002/10/16/pubmed PY - 2003/6/7/medline PY - 2002/10/16/entrez SP - 521 EP - 6 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 30 IS - 8 N2 - The aim of this study was to investigate the effects of HHV-6 DNAemia on the CMV specific lymphoproliferative response after allogeneic stem cell transplantation. Twenty-one allogeneic stem cell transplantation (allo-SCT) patients were included in the study. The patients were either CMV seropositive and/or had CMV seropositive donors. We studied the effects of HHV-6 infection, documented by PCR, on CMV-specific lymphocyte proliferation response and on CMV infection documented by PCR. HHV-6 DNAemia correlated with the absence of CMV-specific lymphocyte proliferation responses after allo-SCT. Three of nine patients with persistent HHV-6 DNA had a CMV-specific lymphocyte proliferative response compared to 11 of 12 patients without persistent HHV-6 DNAemia (P = 0.02). Patients with higher HHV-6 DNA levels (>100 copies) were more likely than those with lower copy numbers not to develop a CMV-specific immune response (six of nine vs one of eight; P < 0.05). Patients who were repeatedly HHV-6 positive in three or more consecutive blood samples were also more likely to need repeated courses of preemptive antiviral therapy against CMV during the first 6 months after transplantation (P < 0.001). Our data indicate the possibility that HHV-6 can suppress the development of CMV-specific immune responses and thereby could predispose to development of late CMV disease. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/12379892/Human_herpesvirus_6_infection_and_cytomegalovirus_specific_lymphoproliferative_responses_in_allogeneic_stem_cell_transplant_recipients_ L2 - https://doi.org/10.1038/sj.bmt.1703657 DB - PRIME DP - Unbound Medicine ER -