Tags

Type your tag names separated by a space and hit enter

Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna.
Food Chem Toxicol. 2002 Oct; 40(10):1475-82.FC

Abstract

The antimutagenic effect of benzene, chloroform, acetone and methanol fractions from Terminalia arjuna, a well-known medicinal plant, was determined against Acid Black dye, 2-aminofluorene (2AF) and 4-nitro-o-phenylenediamine (NPD) in TA98 Frameshift mutagen tester strain of Salmonella typhimurium. Among the different fractions, the antimutagenic effect of acetone and methanol fractions was more than that observed with other fractions. Co-incubation and pre-incubation modes of experimentation did not show much difference in the antimutagenic activity of the extracts. Moreover, these fractions inhibited the S9-dependent mutagens, 2AF and Acid Black dye more effectively than the direct-acting mutagens. Studies are under way to isolate and elucidate the nature of the antimutagenic factor in acetone and methanol fractions.

Authors+Show Affiliations

Kaur K
Department of Botanical Land Environmental Sciences, Guru Nanak Dev University, Amritsar, India. kamal_rajjput@hotmail.com
Arora S
No affiliation info available
Kumar S
No affiliation info available
Nagpal A
No affiliation info available

MeSH

AcetoneAntimutagenic AgentsColoring AgentsFluorenesMethanolMutagenicity TestsMutagensPhenylenediaminesPlant BarkPlant ExtractsTerminalia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12387312

Citation

Kaur, K, et al. "Antimutagenic Activities of Acetone and Methanol Fractions of Terminalia Arjuna." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 40, no. 10, 2002, pp. 1475-82.
Kaur K, Arora S, Kumar S, et al. Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna. Food Chem Toxicol. 2002;40(10):1475-82.
Kaur, K., Arora, S., Kumar, S., & Nagpal, A. (2002). Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 40(10), 1475-82.
Kaur K, et al. Antimutagenic Activities of Acetone and Methanol Fractions of Terminalia Arjuna. Food Chem Toxicol. 2002;40(10):1475-82. PubMed PMID: 12387312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna. AU - Kaur,K, AU - Arora,S, AU - Kumar,S, AU - Nagpal,A, PY - 2002/10/22/pubmed PY - 2002/11/26/medline PY - 2002/10/22/entrez SP - 1475 EP - 82 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 40 IS - 10 N2 - The antimutagenic effect of benzene, chloroform, acetone and methanol fractions from Terminalia arjuna, a well-known medicinal plant, was determined against Acid Black dye, 2-aminofluorene (2AF) and 4-nitro-o-phenylenediamine (NPD) in TA98 Frameshift mutagen tester strain of Salmonella typhimurium. Among the different fractions, the antimutagenic effect of acetone and methanol fractions was more than that observed with other fractions. Co-incubation and pre-incubation modes of experimentation did not show much difference in the antimutagenic activity of the extracts. Moreover, these fractions inhibited the S9-dependent mutagens, 2AF and Acid Black dye more effectively than the direct-acting mutagens. Studies are under way to isolate and elucidate the nature of the antimutagenic factor in acetone and methanol fractions. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/12387312/Antimutagenic_activities_of_acetone_and_methanol_fractions_of_Terminalia_arjuna_ DB - PRIME DP - Unbound Medicine ER -