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Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients.
Scand J Clin Lab Invest 2002; 62(5):385-9SJ

Abstract

In previous studies a high frequency of elevated plasma tHcy concentrations has been observed in psychogeriatric patients (40-50%), but the main cause of these increased concentrations could not be established with certainty. Impaired renal function could partly contribute to elevated plasma tHcy concentrations in psychogeriatric patients. Therefore, in the present study, cystatin C was used as a sensitive marker for glomerular filtration. A linear regression analysis including age, blood folate, serum cobalamin, serum cystatin C and serum creatinine showed that only serum creatinine (p<0.001) and blood folate (p<0.001) independently predicted plasma tHcy concentration. However, about 44% of the patients with elevated plasma tHcy concentrations had signs of reduced glomerular filtration rate, as judged by increased serum cystatin C, whereas only about 13% of the patients with normal concentrations of plasma tHcy had signs of reduced glomerular filtration rate. This finding indicates that renal impairment may to some extent contribute to the elevated plasma tHcy concentration, even though serum cystatin C did not independently predict plasma tHcy concentration.

Authors+Show Affiliations

Department of Psychogeriatrics, University Hospital, Lund, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12387585

Citation

Nilsson, K, et al. "Role of Impaired Renal Function as a Cause of Elevated Plasma Homocysteine Concentration in Psychogeriatric Patients." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 62, no. 5, 2002, pp. 385-9.
Nilsson K, Gustafson L, Hultberg B. Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients. Scand J Clin Lab Invest. 2002;62(5):385-9.
Nilsson, K., Gustafson, L., & Hultberg, B. (2002). Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients. Scandinavian Journal of Clinical and Laboratory Investigation, 62(5), pp. 385-9.
Nilsson K, Gustafson L, Hultberg B. Role of Impaired Renal Function as a Cause of Elevated Plasma Homocysteine Concentration in Psychogeriatric Patients. Scand J Clin Lab Invest. 2002;62(5):385-9. PubMed PMID: 12387585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients. AU - Nilsson,K, AU - Gustafson,L, AU - Hultberg,B, PY - 2002/10/22/pubmed PY - 2003/4/5/medline PY - 2002/10/22/entrez SP - 385 EP - 9 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 62 IS - 5 N2 - In previous studies a high frequency of elevated plasma tHcy concentrations has been observed in psychogeriatric patients (40-50%), but the main cause of these increased concentrations could not be established with certainty. Impaired renal function could partly contribute to elevated plasma tHcy concentrations in psychogeriatric patients. Therefore, in the present study, cystatin C was used as a sensitive marker for glomerular filtration. A linear regression analysis including age, blood folate, serum cobalamin, serum cystatin C and serum creatinine showed that only serum creatinine (p<0.001) and blood folate (p<0.001) independently predicted plasma tHcy concentration. However, about 44% of the patients with elevated plasma tHcy concentrations had signs of reduced glomerular filtration rate, as judged by increased serum cystatin C, whereas only about 13% of the patients with normal concentrations of plasma tHcy had signs of reduced glomerular filtration rate. This finding indicates that renal impairment may to some extent contribute to the elevated plasma tHcy concentration, even though serum cystatin C did not independently predict plasma tHcy concentration. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/12387585/Role_of_impaired_renal_function_as_a_cause_of_elevated_plasma_homocysteine_concentration_in_psychogeriatric_patients_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365510260296546 DB - PRIME DP - Unbound Medicine ER -