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Very high alpha-tocopherol diet diminishes oxidative stress and hypercoagulation in hypertensive rats but not in normotensive rats.
Med Sci Monit. 2002 Oct; 8(10):BR401-7.MS

Abstract

BACKGROUND

Oxidative stress is closely related to cardiovascular diseases, such as atherosclerosis. Increasing dietary antioxidants, such as alpha-tocopherol, may prevent these diseases. However, in some pathologies, such as hypertension, oxidative stress is enhanced, thus alpha-tocopherol requirements may be raised.

MATERIAL/METHODS

In eleven-week-old spontaneously hypertensive rats and normotensive Wistar Kyoto rats, we investigated the effects of a four-week very high alpha-tocopherol dietary enrichment (1,200 mg/kg diet, VH) on blood pressure, resistance to free radical aggression, and VLDL+LDL resistance to lipid peroxidation. Platelet aggregation and plasma lipid profile were also investigated.

RESULTS

With either diet, hypertensive rats were more protected against oxidative stress than normotensive rats. Their capacity to withstand free radical aggression was better, and their VLDL+LDL particles were less sensitive to lipid peroxidation. In either group, the VH diet did not modify blood pressure values when resistance to free radical aggression was increased, but not the resistance of VLDL+LDL to lipid peroxidation. With the control diet, platelet aggregation was faster and higher in hypertensive rats vs. normotensive rats. It was decreased with the VH diet in hypertensive rats but increased in normotensive rats, when compared to their respective controls. Whatever the diet, plasma triacylglycerol, phospholipid and cholesterol concentrations were lower in hypertensive than in normotensive rats. Only cholesterol concentrations were diminished with the VH diet in hypertensive rats, but not in normotensive rats.

CONCLUSIONS

These results indicate that very high alpha-tocopherol dietary amounts decrease cardiovascular risk in hypertensive rats with high oxidative stress, but have less effect on normotensive rats.

Authors+Show Affiliations

UPRES, Lipides et Nutrition, Dijon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12388913

Citation

Frenoux, Jean-Marie R., et al. "Very High Alpha-tocopherol Diet Diminishes Oxidative Stress and Hypercoagulation in Hypertensive Rats but Not in Normotensive Rats." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 8, no. 10, 2002, pp. BR401-7.
Frenoux JM, Noirot B, Prost ED, et al. Very high alpha-tocopherol diet diminishes oxidative stress and hypercoagulation in hypertensive rats but not in normotensive rats. Med Sci Monit. 2002;8(10):BR401-7.
Frenoux, J. M., Noirot, B., Prost, E. D., Madani, S., Blond, J. P., Belleville, J. L., & Prost, J. L. (2002). Very high alpha-tocopherol diet diminishes oxidative stress and hypercoagulation in hypertensive rats but not in normotensive rats. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 8(10), BR401-7.
Frenoux JM, et al. Very High Alpha-tocopherol Diet Diminishes Oxidative Stress and Hypercoagulation in Hypertensive Rats but Not in Normotensive Rats. Med Sci Monit. 2002;8(10):BR401-7. PubMed PMID: 12388913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Very high alpha-tocopherol diet diminishes oxidative stress and hypercoagulation in hypertensive rats but not in normotensive rats. AU - Frenoux,Jean-Marie R, AU - Noirot,Beatrice, AU - Prost,Emmanuelle D, AU - Madani,Sihem, AU - Blond,Jean Paul, AU - Belleville,Jacques L, AU - Prost,Josiane L, PY - 2002/10/22/pubmed PY - 2003/6/11/medline PY - 2002/10/22/entrez SP - BR401 EP - 7 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 8 IS - 10 N2 - BACKGROUND: Oxidative stress is closely related to cardiovascular diseases, such as atherosclerosis. Increasing dietary antioxidants, such as alpha-tocopherol, may prevent these diseases. However, in some pathologies, such as hypertension, oxidative stress is enhanced, thus alpha-tocopherol requirements may be raised. MATERIAL/METHODS: In eleven-week-old spontaneously hypertensive rats and normotensive Wistar Kyoto rats, we investigated the effects of a four-week very high alpha-tocopherol dietary enrichment (1,200 mg/kg diet, VH) on blood pressure, resistance to free radical aggression, and VLDL+LDL resistance to lipid peroxidation. Platelet aggregation and plasma lipid profile were also investigated. RESULTS: With either diet, hypertensive rats were more protected against oxidative stress than normotensive rats. Their capacity to withstand free radical aggression was better, and their VLDL+LDL particles were less sensitive to lipid peroxidation. In either group, the VH diet did not modify blood pressure values when resistance to free radical aggression was increased, but not the resistance of VLDL+LDL to lipid peroxidation. With the control diet, platelet aggregation was faster and higher in hypertensive rats vs. normotensive rats. It was decreased with the VH diet in hypertensive rats but increased in normotensive rats, when compared to their respective controls. Whatever the diet, plasma triacylglycerol, phospholipid and cholesterol concentrations were lower in hypertensive than in normotensive rats. Only cholesterol concentrations were diminished with the VH diet in hypertensive rats, but not in normotensive rats. CONCLUSIONS: These results indicate that very high alpha-tocopherol dietary amounts decrease cardiovascular risk in hypertensive rats with high oxidative stress, but have less effect on normotensive rats. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/12388913/Very_high_alpha_tocopherol_diet_diminishes_oxidative_stress_and_hypercoagulation_in_hypertensive_rats_but_not_in_normotensive_rats_ L2 - https://www.medscimonit.com/download/index/idArt/4877 DB - PRIME DP - Unbound Medicine ER -