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Serum leptin levels in acromegaly--a significant role for adipose tissue and fasting insulin/glucose ratio.
Med Sci Monit. 2002 Oct; 8(10):CR685-9.MS

Abstract

BACKGROUND

Leptin plays an important role in controlling satiety and maintaining energy balance. Acromegaly is characterized by decreased fat, which increases after the disease is cured. Our objective was to investigate serum leptin in acromegaly in terms of disease activity, body fat content, insulin and glucose levels, and selected anthropometric variables.

MATERIAL/METHODS

We examined 40 patients with acromegaly and 20 sex- and age-matched controls for the levels of serum GH, IGF-I, leptin, glucose, and insulin, and for body composition by DEXA, BMI and WHR. In 10 cases the acute effect on serum leptin of a somatostatin analogue, lanreotide, was studied.

RESULTS

We observed lower leptin in patients with active acromegaly than in cured patients and controls. Body fat was higher in cured than active patients. In the patients, we found significant correlations (p<0.05) between leptin and percent body fat (r=0.77), leptin and body fat mass (r=0.74), leptin and fasting insulin (r=0.62), leptin and fasting insulin/glucose ratio (r=0.97), leptin and BMI (r=0.44), leptin and height (r=-0.47). In the controls there was a significant correlation (p<0.05) only between leptin and WHR (r=-0.45). A paradoxical decrease of the leptin level after lanreotide was observed in 7 out of 10 patients with active acromegaly.

CONCLUSIONS

Changes in leptin release in acromegaly are related to differences in body fat content and mass, and in insulin resistance. Leptin in acromegaly is not influenced directly by GH or IGF-I secretion. The acute effect of medical treatment of acromegaly by a somatostatin analogue on leptin levels differs from the effect of a radical cure following pituitary adenoma surgery.

Authors+Show Affiliations

Bolanowski M
Department of Endocrinology and Diabetology, Medical University, Wrocław, Poland. bolan@endo.am.wroc.pl
Milewicz A
No affiliation info available
Bidzińska B
No affiliation info available
Jedrzejuk D
No affiliation info available
Daroszewski J
No affiliation info available
Mikulski E
No affiliation info available

MeSH

AcromegalyAdipose TissueAdultBlood GlucoseFastingFemaleGrowth HormoneHumansInsulinInsulin-Like Growth Factor ILeptinMaleMiddle AgedStatistics as Topic

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12388920

Citation

Bolanowski, Marek, et al. "Serum Leptin Levels in Acromegaly--a Significant Role for Adipose Tissue and Fasting Insulin/glucose Ratio." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 8, no. 10, 2002, pp. CR685-9.
Bolanowski M, Milewicz A, Bidzińska B, et al. Serum leptin levels in acromegaly--a significant role for adipose tissue and fasting insulin/glucose ratio. Med Sci Monit. 2002;8(10):CR685-9.
Bolanowski, M., Milewicz, A., Bidzińska, B., Jedrzejuk, D., Daroszewski, J., & Mikulski, E. (2002). Serum leptin levels in acromegaly--a significant role for adipose tissue and fasting insulin/glucose ratio. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 8(10), CR685-9.
Bolanowski M, et al. Serum Leptin Levels in Acromegaly--a Significant Role for Adipose Tissue and Fasting Insulin/glucose Ratio. Med Sci Monit. 2002;8(10):CR685-9. PubMed PMID: 12388920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin levels in acromegaly--a significant role for adipose tissue and fasting insulin/glucose ratio. AU - Bolanowski,Marek, AU - Milewicz,Andrzej, AU - Bidzińska,Bozena, AU - Jedrzejuk,Diana, AU - Daroszewski,Jacek, AU - Mikulski,Emil, PY - 2002/10/22/pubmed PY - 2003/6/11/medline PY - 2002/10/22/entrez SP - CR685 EP - 9 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 8 IS - 10 N2 - BACKGROUND: Leptin plays an important role in controlling satiety and maintaining energy balance. Acromegaly is characterized by decreased fat, which increases after the disease is cured. Our objective was to investigate serum leptin in acromegaly in terms of disease activity, body fat content, insulin and glucose levels, and selected anthropometric variables. MATERIAL/METHODS: We examined 40 patients with acromegaly and 20 sex- and age-matched controls for the levels of serum GH, IGF-I, leptin, glucose, and insulin, and for body composition by DEXA, BMI and WHR. In 10 cases the acute effect on serum leptin of a somatostatin analogue, lanreotide, was studied. RESULTS: We observed lower leptin in patients with active acromegaly than in cured patients and controls. Body fat was higher in cured than active patients. In the patients, we found significant correlations (p<0.05) between leptin and percent body fat (r=0.77), leptin and body fat mass (r=0.74), leptin and fasting insulin (r=0.62), leptin and fasting insulin/glucose ratio (r=0.97), leptin and BMI (r=0.44), leptin and height (r=-0.47). In the controls there was a significant correlation (p<0.05) only between leptin and WHR (r=-0.45). A paradoxical decrease of the leptin level after lanreotide was observed in 7 out of 10 patients with active acromegaly. CONCLUSIONS: Changes in leptin release in acromegaly are related to differences in body fat content and mass, and in insulin resistance. Leptin in acromegaly is not influenced directly by GH or IGF-I secretion. The acute effect of medical treatment of acromegaly by a somatostatin analogue on leptin levels differs from the effect of a radical cure following pituitary adenoma surgery. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/12388920/Serum_leptin_levels_in_acromegaly__a_significant_role_for_adipose_tissue_and_fasting_insulin/glucose_ratio_ DB - PRIME DP - Unbound Medicine ER -