Tags

Type your tag names separated by a space and hit enter

Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora.
Am J Obstet Gynecol. 2002 Oct; 187(4):877-81.AJ

Abstract

OBJECTIVE

The purpose of this study was to determine whether the microbial hydrolytic enzymes, sialidase and prolidase, and immunoglobulin A against the Gardnerella vaginalis cytolysin (anti-Gvh IgA) increase the risk for early preterm birth (< or =34 weeks of gestation) among women with bacterial vaginosis or intermediate flora.

STUDY DESIGN

Two hundred eighteen afebrile women in preterm labor with intact membranes had a vaginal Gram stain performed, and sialidase, prolidase, and anti-Gvh IgA concentrations were determined.

RESULTS

Women with bacterial vaginosis or intermediate flora had significantly higher sialidase and prolidase concentrations than women with normal flora. Among women with bacterial vaginosis or intermediate flora, the women with sialidase had a higher rate of early preterm birth (P =.05). Sialidase had a sensitivity of 43% and specificity of 77% for early preterm birth. Prolidase and anti-Gvh IgA did not predict early preterm birth.

CONCLUSION

Women in preterm labor with bacterial vaginosis or intermediate flora and detectable sialidase are at increased risk of early preterm birth.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Cauci S
Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Udine, Italy.
Hitti J
No affiliation info available
Noonan C
No affiliation info available
Agnew K
No affiliation info available
Quadrifoglio F
No affiliation info available
Hillier SL
No affiliation info available
Eschenbach DA
No affiliation info available

MeSH

AdolescentAdultBacterial InfectionsBacterial ToxinsDipeptidasesFemaleGardnerella vaginalisHumansHydrolasesImmunoglobulin ANeuraminidaseObstetric Labor, PrematurePregnancyRisk FactorsVaginaVaginosis, Bacterial

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12388968

Citation

Cauci, Sabina, et al. "Vaginal Hydrolytic Enzymes, Immunoglobulin a Against Gardnerella Vaginalis Toxin, and Risk of Early Preterm Birth Among Women in Preterm Labor With Bacterial Vaginosis or Intermediate Flora." American Journal of Obstetrics and Gynecology, vol. 187, no. 4, 2002, pp. 877-81.
Cauci S, Hitti J, Noonan C, et al. Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora. Am J Obstet Gynecol. 2002;187(4):877-81.
Cauci, S., Hitti, J., Noonan, C., Agnew, K., Quadrifoglio, F., Hillier, S. L., & Eschenbach, D. A. (2002). Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora. American Journal of Obstetrics and Gynecology, 187(4), 877-81.
Cauci S, et al. Vaginal Hydrolytic Enzymes, Immunoglobulin a Against Gardnerella Vaginalis Toxin, and Risk of Early Preterm Birth Among Women in Preterm Labor With Bacterial Vaginosis or Intermediate Flora. Am J Obstet Gynecol. 2002;187(4):877-81. PubMed PMID: 12388968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora. AU - Cauci,Sabina, AU - Hitti,Jane, AU - Noonan,Carolyn, AU - Agnew,Kathy, AU - Quadrifoglio,Franco, AU - Hillier,Sharon L, AU - Eschenbach,David A, PY - 2002/10/22/pubmed PY - 2002/11/26/medline PY - 2002/10/22/entrez SP - 877 EP - 81 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 187 IS - 4 N2 - OBJECTIVE: The purpose of this study was to determine whether the microbial hydrolytic enzymes, sialidase and prolidase, and immunoglobulin A against the Gardnerella vaginalis cytolysin (anti-Gvh IgA) increase the risk for early preterm birth (< or =34 weeks of gestation) among women with bacterial vaginosis or intermediate flora. STUDY DESIGN: Two hundred eighteen afebrile women in preterm labor with intact membranes had a vaginal Gram stain performed, and sialidase, prolidase, and anti-Gvh IgA concentrations were determined. RESULTS: Women with bacterial vaginosis or intermediate flora had significantly higher sialidase and prolidase concentrations than women with normal flora. Among women with bacterial vaginosis or intermediate flora, the women with sialidase had a higher rate of early preterm birth (P =.05). Sialidase had a sensitivity of 43% and specificity of 77% for early preterm birth. Prolidase and anti-Gvh IgA did not predict early preterm birth. CONCLUSION: Women in preterm labor with bacterial vaginosis or intermediate flora and detectable sialidase are at increased risk of early preterm birth. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/12388968/Vaginal_hydrolytic_enzymes_immunoglobulin_A_against_Gardnerella_vaginalis_toxin_and_risk_of_early_preterm_birth_among_women_in_preterm_labor_with_bacterial_vaginosis_or_intermediate_flora_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937802002594 DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓11]

Related Citations

More