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Prenatal evaluation of facial clefts with two-dimensional and adjunctive three-dimensional ultrasonography: a prospective trial.
Am J Obstet Gynecol. 2002 Oct; 187(4):946-9.AJ

Abstract

OBJECTIVE

The purpose of this study was to compare the prenatal diagnostic capabilities of two-dimensional ultrasonography versus adjunctive three-dimensional ultrasonography for fetal cleft lip and palate.

STUDY DESIGN

Fetuses that were suspected of a facial cleft were then examined sequentially with two-dimensional ultrasonography then with a targeted scan of the fetal face with three-dimensional ultrasonography. The images were coded as cleft, no cleft, or equivocal for lip and palate. Postnatal outcome follow-up was obtained.

RESULTS

Fifty-three of 57 fetuses had outcome results available. The diagnostic accuracy (true positive + true negative) of adjunct three-dimensional ultrasonography versus two-dimensional ultrasonography alone were improved for cleft lip (100% [53/53 fetuses] vs 91% [48/53 fetuses], P <.05) and cleft palate (89% [47/53 fetuses] vs 57% [30/53 fetuses], P <.05)

CONCLUSION

There is significant improvement in diagnostic accuracy with two-dimensional ultrasonography with adjunctive three-dimensional ultrasonography compared with two-dimensional ultrasonography alone for the prenatal evaluation of facial clefts.

Authors+Show Affiliations

Division of Reproductive Medicine, University of California, San Diego, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

12388983

Citation

Chmait, Ramen, et al. "Prenatal Evaluation of Facial Clefts With Two-dimensional and Adjunctive Three-dimensional Ultrasonography: a Prospective Trial." American Journal of Obstetrics and Gynecology, vol. 187, no. 4, 2002, pp. 946-9.
Chmait R, Pretorius D, Jones M, et al. Prenatal evaluation of facial clefts with two-dimensional and adjunctive three-dimensional ultrasonography: a prospective trial. Am J Obstet Gynecol. 2002;187(4):946-9.
Chmait, R., Pretorius, D., Jones, M., Hull, A., James, G., Nelson, T., & Moore, T. (2002). Prenatal evaluation of facial clefts with two-dimensional and adjunctive three-dimensional ultrasonography: a prospective trial. American Journal of Obstetrics and Gynecology, 187(4), 946-9.
Chmait R, et al. Prenatal Evaluation of Facial Clefts With Two-dimensional and Adjunctive Three-dimensional Ultrasonography: a Prospective Trial. Am J Obstet Gynecol. 2002;187(4):946-9. PubMed PMID: 12388983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal evaluation of facial clefts with two-dimensional and adjunctive three-dimensional ultrasonography: a prospective trial. AU - Chmait,Ramen, AU - Pretorius,Dolores, AU - Jones,Marilyn, AU - Hull,Andrew, AU - James,Gina, AU - Nelson,Tom, AU - Moore,Thomas, PY - 2002/10/22/pubmed PY - 2002/11/26/medline PY - 2002/10/22/entrez SP - 946 EP - 9 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 187 IS - 4 N2 - OBJECTIVE: The purpose of this study was to compare the prenatal diagnostic capabilities of two-dimensional ultrasonography versus adjunctive three-dimensional ultrasonography for fetal cleft lip and palate. STUDY DESIGN: Fetuses that were suspected of a facial cleft were then examined sequentially with two-dimensional ultrasonography then with a targeted scan of the fetal face with three-dimensional ultrasonography. The images were coded as cleft, no cleft, or equivocal for lip and palate. Postnatal outcome follow-up was obtained. RESULTS: Fifty-three of 57 fetuses had outcome results available. The diagnostic accuracy (true positive + true negative) of adjunct three-dimensional ultrasonography versus two-dimensional ultrasonography alone were improved for cleft lip (100% [53/53 fetuses] vs 91% [48/53 fetuses], P <.05) and cleft palate (89% [47/53 fetuses] vs 57% [30/53 fetuses], P <.05) CONCLUSION: There is significant improvement in diagnostic accuracy with two-dimensional ultrasonography with adjunctive three-dimensional ultrasonography compared with two-dimensional ultrasonography alone for the prenatal evaluation of facial clefts. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/12388983/Prenatal_evaluation_of_facial_clefts_with_two_dimensional_and_adjunctive_three_dimensional_ultrasonography:_a_prospective_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937802002740 DB - PRIME DP - Unbound Medicine ER -