TY - JOUR T1 - Prenatal evaluation of facial clefts with two-dimensional and adjunctive three-dimensional ultrasonography: a prospective trial. AU - Chmait,Ramen, AU - Pretorius,Dolores, AU - Jones,Marilyn, AU - Hull,Andrew, AU - James,Gina, AU - Nelson,Tom, AU - Moore,Thomas, PY - 2002/10/22/pubmed PY - 2002/11/26/medline PY - 2002/10/22/entrez SP - 946 EP - 9 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 187 IS - 4 N2 - OBJECTIVE: The purpose of this study was to compare the prenatal diagnostic capabilities of two-dimensional ultrasonography versus adjunctive three-dimensional ultrasonography for fetal cleft lip and palate. STUDY DESIGN: Fetuses that were suspected of a facial cleft were then examined sequentially with two-dimensional ultrasonography then with a targeted scan of the fetal face with three-dimensional ultrasonography. The images were coded as cleft, no cleft, or equivocal for lip and palate. Postnatal outcome follow-up was obtained. RESULTS: Fifty-three of 57 fetuses had outcome results available. The diagnostic accuracy (true positive + true negative) of adjunct three-dimensional ultrasonography versus two-dimensional ultrasonography alone were improved for cleft lip (100% [53/53 fetuses] vs 91% [48/53 fetuses], P <.05) and cleft palate (89% [47/53 fetuses] vs 57% [30/53 fetuses], P <.05) CONCLUSION: There is significant improvement in diagnostic accuracy with two-dimensional ultrasonography with adjunctive three-dimensional ultrasonography compared with two-dimensional ultrasonography alone for the prenatal evaluation of facial clefts. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/12388983/Prenatal_evaluation_of_facial_clefts_with_two_dimensional_and_adjunctive_three_dimensional_ultrasonography:_a_prospective_trial_ DB - PRIME DP - Unbound Medicine ER -